Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of p75ECD in preparation of drugs for treating myocardial infarction

A technology for the preparation of drugs, p75ecd-fc, which is applied in the field of medicine, can solve problems such as myocardial infarction, and achieve the effects of protecting the myocardium, reducing the size of myocardial infarction, and improving cardiac remodeling and function

Inactive Publication Date: 2019-07-12
陈良龙 +2
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the prior art has recognized that p75ECD is a neuroprotective factor, it has not clearly mentioned that it can protect the myocardium

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of p75ECD in preparation of drugs for treating myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: p75ECD reduces myocardial infarction size

[0038] 200-250g SD rats were divided into the following 4 groups (n=6): model control group, p75ECD1mg / kg, 3mg / kg, 9mg / kg groups. Administration was given 5 minutes before reperfusion, and 24 hours after reperfusion, the left main coronary artery was ligated again, and rats were killed by injecting 0.1% Evans blue and 10% KCl through the external jugular vein. , Determination of left ventricular section, ischemic survival area and necrotic area (AN) area, ischemic risk area (AAR) is the sum of ischemic survival area and necrotic area, and the infarct area is represented by AN / AAR. Results The area of ​​myocardial infarction in the four groups was (45±4)%, (41±6)%, (35±6)%, (34±3)%. It showed that the 1mg / kg group had no cardioprotective effect, and both the 3mg / kg and 9mg / kg groups had cardioprotective effects, with P values ​​of 0.001, and the 9mg / kg group had no further advantage over the 3mg / kg group. Therefore...

Embodiment 2

[0039] Example 2: p75ECD improves cardiac function

[0040] Further use the optimal dose of p75ECD cardioprotection 3mg / kg to evaluate cardiac remodeling and function by echocardiography on day 28 of reperfusion. The rats weighed 350-450 g at the time of testing, and were divided into the following three groups (n=5): model control group, sham operation group, and p75ECD 3 mg / kg group. Results The left ventricular end-diastolic diameter (LVEDd), which represents the index of ventricular remodeling, was (11.36±0.52) mm, (8.83±0.65) mm and (9.98±0.30) mm in the three groups, and the left ventricular systolic function index in the three groups was ejected Fractions (LVEF) were (30±2)%, (62±8)% and (40±6)%, respectively, short-axis shortening (LVFS) were (16±1)%, (35±6)% and (22±3)%. There were statistical differences in the above three indexes among the three groups, all P values ​​were <0.05, indicating that the p75ECD3mg / kg group could improve ventricular remodeling and cardi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of medicine, discloses an application of p75ECD in preparation of drugs for treating myocardial infarction, and especially relates to a method for prevention and / ortreatment of myocardial infarction / myocardial reperfusion injury. The method includes the step of administering an effective dose of a p75 extracellular structural domain (p75ECD) to a desired objectbefore reperfusion.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to the use of the extracellular domain of neurotrophic factor receptor p75, especially for the prevention and / or treatment of myocardial infarction / myocardial reperfusion injury. Background technique [0002] After acute myocardial infarction, reperfusion and reduction of myocardial infarction size by means of thrombolysis or percutaneous coronary intervention are the most effective strategies to improve clinical prognosis. However, clinically, the mortality rate of myocardial infarction is still close to 10%, and the incidence rate of chronic heart failure is as high as 25%. In addition to the excessive myocardial cell necrosis caused by ischemia itself, the ischemic myocardium may cause further damage in ultrastructure, function, metabolism and electrophysiology after the blood perfusion is restored, which is the damage caused again on the basis of ischemic injury , known as my...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/17A61P9/10
CPCA61K38/177
Inventor 陈良龙方军周新富
Owner 陈良龙
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com