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Thymus plant extract and application thereof

A technology of Thyme extract and Thyme genus, which is applied in the field of medicine and can solve the problems of late start of research

Active Publication Date: 2017-01-25
折改梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

China's research on Thyme plants mainly focuses on the research on the volatile oil components and antibacterial properties of Thyme, and the research on other active fields started relatively late

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] Embodiment 1: the preparation of ground pepper extract

[0122] Take 10.0 kg of ground pepper medicinal material, first cold soak with 15 times the amount of acetone for 24 hours, and then use 2% H 2 SO 4 After acidification, the extract was extracted twice with ethyl acetate, and the extracts were combined. Reduce the pressure to 0.06 MPa, recover ethyl acetate, and obtain about 55 g of extract. The content of carvacrol, danshensu, scutellarein, scutellarin, 5,4'-dihydroxy-6,7,8-trimethoxyflavone, oleanolic acid and rosmarinic acid in the extract is 9.1% . Among them, the content of carvacrol is 0.6%, the content of danshenin is 0.5%, the content of scutellarein is 0.7%, the content of scutellarin is 2%, 5,4'-dihydroxy-6,7,8-trimethoxy The flavonoid content is 3%, the oleanolic acid content is 2%, and the rosmarinic acid content is 0.3%. Get 20 g of medicinal extract and dissolve in water and be mixed with the solution that weight fraction is 20%, filter, get uppe...

Embodiment 2

[0123] Embodiment 2: the preparation of thyme extract

[0124] Take 10.0 kg of thyme medicinal material, cold soak with 15 times the amount of acetone for 24 hours, and then use 2% H 2 SO 4 After acidification, the extracts were extracted twice with ethyl acetate respectively, and the extracts were combined. Reduce the pressure to 0.06 MPa, recover ethyl acetate, and obtain about 49 g of extract. The content of carvacrol, danshensu, scutellarein, scutellarin, 5,4'-dihydroxy-6,7,8-trimethoxyflavone, oleanolic acid and rosmarinic acid in the extract is 8.3% . Among them, the content of carvacrol is 0.6%, the content of danshenin is 0.7%, the content of scutellarein is 0.8%, the content of scutellarin is 2%, 5,4'-dihydroxy-6,7,8-trimethyl The content of oxyflavone is 2%, the content of oleanolic acid is 2%, and the content of rosmarinic acid is 0.2%. Get 20 g of medicinal extract and dissolve in water and be mixed with the solution that weight fraction is 20%, filter, get up...

Embodiment 3

[0125] Embodiment 3: the preparation of heterogeneous thyme extract

[0126] Take 10.0 kg of different thyme medicinal materials, first use 15 times the amount of acetone to cold soak for 24 hours, and then use 2% H 2 SO 4After acidification, the extracts were extracted twice with ethyl acetate respectively, and the extracts were combined. Reduce the pressure to 0.06 MPa, recover ethyl acetate, and obtain about 46 g of extract. The content of carvacrol, danshensu, scutellarein, scutellarin, 5,4'-dihydroxy-6,7,8-trimethoxyflavone, oleanolic acid and rosmarinic acid in the extract is 7.3% . Among them, the content of carvacrol is 0.25%, the content of danshenin is 0.75%, the content of scutellarein is 0.6%, the content of scutellarin is 2%, 5,4'-dihydroxy-6,7,8-trimethoxy The content of flavonoids is 1.5%, the content of oleanolic acid is 1.5%, and the content of rosmarinic acid is 0.7%. Get 20 g of medicinal extract and dissolve in water and be mixed with the solution that...

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Abstract

The invention relates to a thymus plant extract or composition and application thereof. The preparation method comprises the following steps: firstly quenching active pharmaceutical ingredients with acetone; performing acidification by use of H2SO4 with certain concentration; extracting the extracting solution with ethyl acetate for 2-3 times, thereby obtaining a thymus plant extract containing carvacrol, tanshinol, scutellarein, scutellarin, 5,4'-dyhydroxyl-6,7,8-trimethoxy flavone, oleanolic acid and rosmarinic acid. The thymus plant also provides a traditional Chinese medicine composition for treating cardiovascular and cerebrovascular disease. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 200-500 parts of thymus plant, 100-300 parts of curcuma roots, 100-300 parts of rhizoma sparganii, 200-400 parts of radix angelica sinensis, 100-200 parts of ginkgo leaves, 100-200 parts of licorice root, 200-400 parts of radix codonopsis pilosulae and 200-500 parts of rhizoma ligustici wallichii. The traditional Chinese medicine composition is rapid in medical effect taking and less in toxic and side effects, thereby being a favorable medicament for treating cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a plant of the genus Thyme in the treatment of cardiovascular and cerebrovascular diseases, in particular a plant of the genus Thyme of Labiatae distributed in China. Background technique [0002] Thymus vulgaris. Linn Aeus is a general term for plants of the genus Thymus in the family Labiatae, and is a perennial low subshrub. It is named for the strong aromatic smell of its plants during flowering. According to "Flora of China" volume 66 (1977), there are 300-400 species of thyme in the world, and the origin is the Mediterranean coast, and the main origin is France and Spain. According to relevant records, there are 12 species and 2 varieties of Thyme in China. After actually consulting the flora of various places, it was found that some varieties were not included in the "Flora of China". Therefore, in fact, there are 17 species and 2 varieties of Thyme...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K36/9066A61P9/00A61P9/10A61P3/06A61P9/12A61P9/06A61P9/04A61P3/10A61P7/02A61P25/28A61P25/16
CPCA61K36/16A61K36/232A61K36/236A61K36/344A61K36/484A61K36/53A61K36/902A61K36/9066A61K2236/33A61K2236/39A61K2300/00
Inventor 折改梅陈晓怡白少娟赵怡程何婷田玉欣王炎
Owner 折改梅
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