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Left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation

A geometric model and curative effect evaluation technology, applied in 3D modeling, medical practical experience/guidance, image data processing, etc., can solve the problem of huge cost of hydrogel curative effect

Active Publication Date: 2020-08-25
LUDONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in vivo experiments to assess the efficacy of hydrogels are costly
At present, there are relatively few studies that use geometric modeling and biocomputation methods combined with experimental data to gain an in-depth understanding of the effects of hydrogels with different stiffnesses and different volumes on the stress and thickness of the ventricular wall.

Method used

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  • Left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation
  • Left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation
  • Left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation

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Embodiment 1

[0065] The embodiment of the present invention provides a method for constructing a geometric model of the left ventricle for evaluating the curative effect of an injectable hydrogel, such as figure 1 As shown, the method includes:

[0066] S1: Obtain a magnetic resonance (MRI, Magnetic Resonance Imaging) image including the left ventricle.

[0067] S2: Segment the magnetic resonance image to obtain a collection of different organ tissues of the left ventricle.

[0068] S3: For each pixel, construct a three-variable quadratic polynomial volume function block on the 3×3×3 image block centered on the pixel.

[0069] In this step, the pixel P i,j,k The corresponding three-dimensional coordinates are (i, j, k), for each pixel P i,j,k , taking it as the center to divide the image block of 3×3×3, taking the step size between the pixels of the MRI image in the three directions of xyz as 1, and for each pixel P i,j,k , get a 3×3×3 image block respectively, for each pixel P i,j,k ...

Embodiment 2

[0131] The embodiment of the present invention provides a method for constructing a geometric model of the left ventricle for evaluating the curative effect of an injectable hydrogel, such as figure 2 As shown, the device includes:

[0132] The acquisition module 1 is configured to acquire a magnetic resonance image including the left ventricle.

[0133] The segmentation module 2 is configured to segment the magnetic resonance image to obtain different organ and tissue sets of the left ventricle.

[0134]The quadratic polynomial volume function block construction module 3 is used for constructing a three-variable quadratic polynomial volume function block on a 3×3×3 image block centered on the pixel for each pixel.

[0135] Cubic polynomial volume function block construction module 4, for each unit cube formed by adjacent 8 pixels, the quadratic polynomial volume function block weighted average of all pixels in the cube, to construct a three-variable cubic polynomial volume ...

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Abstract

The invention discloses a left ventricle geometric model construction method and device for injectable hydrogel curative effect evaluation, and belongs to the field of image processing. The method comprises the following steps: acquiring a magnetic resonance image comprising a left ventricle; segmenting the magnetic resonance image to obtain different organ tissue sets of the left ventricle; for each pixel, constructing a three-variable quadratic polynomial volume function block on a 3*3*3 image block taking the pixel as the center; on each unit cube formed by eight adjacent pixels, weightingand averaging the quadratic polynomial volume function blocks of all the pixels in the cube, and constructing a three-variable cubic polynomial volume function block; and combining all cubic polynomial volume function blocks together to obtain a left ventricle three-dimensional geometric model. The method for constructing the high-precision left ventricular solid model is provided for evaluating the curative effect of the hydrogel on myocardial infarction treatment, an effective technology is provided for high-accuracy evaluation, and an important auxiliary technology is provided for medical staff to improve the curative effect on myocardial infarction treatment.

Description

technical field [0001] The invention relates to the field of computer image processing, in particular to a method and a device for constructing a left ventricle geometric model for evaluating curative effect of an injectable hydrogel. Background technique [0002] Cardiovascular disease is a leading cause of death worldwide and may eventually lead to heart failure due to poor remodeling of the ventricular wall. Therefore, the material properties of the myocardium play an important role in the study of LV function in health and disease. Injectable hydrogel is a biocompatible injectable material that has shown remarkable efficacy in attenuating ventricular remodeling. A variety of hydrogels of different materials are currently being used to assess the effect on ventricular wall thickness and left ventricular function. Many in vivo experimental studies have proved that injectable hydrogel can play a certain effective role in the treatment of myocardial infarction. [0003] T...

Claims

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Application Information

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IPC IPC(8): G16H70/20G06T7/00G06T7/11G06T17/00
CPCG06T7/0012G06T17/00G06T2207/10088G06T2207/30048G06T7/11G16H70/20
Inventor 王桦张帆张小峰
Owner LUDONG UNIVERSITY
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