105 results about "Dinitrophenyl" patented technology

An organic luminescent material including a compound of the following formula: wherein: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are individual groups, and at least one group is not hydrogen among the R1, R3, R7, and R9 groups. Group 1: hydrogen, or alkyl of from 1 to 48 carbon atoms, and each R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 can connect with their neighboring group to form 5 or 6 member cyclic or aromatic ring system, and Group 2: aryl or substituted aryl of from 5 to 48 carbon atoms, or 4 to 48 carbon atoms necessary to complete a fused aromatic ring of naphthenyl, anthracenyl, pyrenyl, or perylenyl; and Group 3: heteroaryl or substituted heteroaryl of from 5 to 24 carbon atoms, or 4 to 48 carbon atoms necessary to complete a fused heteroaromatic ring of furyl, thienyl, pyridyl, quinolinyl and other heterocyclic systems; and Group 4: alkoxyl, amino, alkyl amino, aryl amino dialkyl amino, or diaryl amino of from 1 to 24 carbon atoms; and Group 5: a group consist of F, Cl, Br, I, CN, NCS, NCO, B(OH)2, B(OCH2CH2O), B[OC(CH3)2C(CH3)2O], SO2R13, SO3R14, SO2NR2, SiR3, SiHR2, SiR2OH, where R, R13 and R14 is hydrogen, chlorine, bromine, alkyl group containing 1-12 carbon atoms, and aryl; and Group 6: a group of formula -LYnR15 where n is 0 to 18, Y is a alkyl group contains 1 to 24 carbon atoms, R15 is a hydrogen, hydroxy, amino, alkylamino, arylamino, alkyl arylamino, diarylamino, dialkylamino, or —COR16 where R16 is a hydrogen, chlorine, COCl, alkyl group containing 1-12 carbon atoms, —NR2, —NHR and aryl, or —COOR17 where R17 is a hydrogen, alkyl group containing 1-12 carbon atoms, aryl, COR, 2,4-dinitrophenyl, N-imido or —NR2; and L is a direct bond or C═O.

The invention provides a novel method for preparing an aromatic amine compound through halogenated aromatic hydrocarbon and an organic amine zinc chloride complex compound. A reaction general formula is as shown in a figure in the specification, wherein Ar is aryl and can be selected from 2,4-dinitrophenyl, p-nitrophenyl, 2-nitro-4-chlorphenyl, p-trifluoromethylphenyl, 4-formaldehyde phenyl, 2-pyrimidyl, and the like; X can be selected from F, Cl, Br, I, and the like; R1 and R2 are H, alkyl, aryl or heteroaryl, or R1 and R2 form a ternary to heptatomic naphthenic base together with carbon atoms connected with R1 and R2; reaction media are methylbenzene, dimethyl sulfoxide, N,N-dimethylformamide, tetrahydrofuran, dioxane, acetone and water; reacted alkalis are cesium carbonate, potassium phosphate, triethylamine, potassium carbonate, sodium (potassium) hydroxide and sodium (potassium) alkoxide; reaction can be implemented through both conventional heating and microwave promotion; and the means of recrystallization or column chromatography is adopted for purification. The invention provides a low-cost non-toxic efficient green method (without ligands) for establishing an aromatic C-N bond.

The invention provides a derivatization separation and detection method of a glycyl-L-glutamine chiral isomer, and belongs to the field of analytical chemistry. The method comprises the steps that before the glycyl-L-glutamine chiral isomer enters a liquid chromatographic column, derivatization is conducted through a derivatization reagent, and the derivatization reagent adopts an N<alpha>-(5-fluorine-2,4-dinitrophenyl)-L-amino acid compound. The separation determination method is high efficiency liquid chromatography. The used chromatographic column is a chromatographic column which takes base octadecyl bonded silica as filler. The separation and detection method mainly comprises the steps of preparing a sample solution and a derivative solution, conducting a derivative reaction, conducting derivative reaction aftertreatment and conducting separation determination through a high performance liquid chromatographic instrument. The pre-column derivatization method has the advantages that the reaction condition is mild, derived products are stable, the reaction velocity is high, the side reactions are few, determination is not disturbed by the excess derivatization reagent, and separation between glycyl-L-glutamine and the chiral isomer of the glycyl-L-glutamine can be achieved by using an ordinary chromatographic column.

The invention belongs to the field of chemical analysis and detection, and particularly discloses a water-soluble double-photon fluorescent probe capable of being directly used for detecting hydrogensulfide in red wine, cancer cells and tissues, and a preparation method and application of the water-soluble two-photon fluorescent probe. According to the fluorescent probe, a coumarin derivative with a double-photon property is taken as a signal group, 2,4-dinitrophenyl ether is taken a hydrogen sulfide recognition group, and the structure of the fluorescent probe is represented as in a formula(I). The fluorescent probe is good in water solubility, high in selectivity, excellent in anti-interference capability and high in sensitivity, can be directly used for rapid detection of hydrogen sulfide in red wine, cancer cells and tissues, and has a good application prospect.

A preparing method of N-(2,4-dinitrophenyl)rhodamine B-hydrazide and an application of the N-(2,4-dinitrophenyl)rhodamine B-hydrazide for detection of Cu(II) are disclosed. The preparing method includes a step of reacting rhodamine B acid chloride and 2,4-dinitrophenylhydrazine to generate the N-(2,4-dinitrophenyl)rhodamine B-hydrazide. The N-(2,4-dinitrophenyl)rhodamine B-hydrazide itself is free of color and fluorescence, but can generate coloring and fluorescence generating reactions selectively with Cu<2+>, so that a colorless substance is turned into a system with excellent optical properties, and detection sensitivity and selectivity for the Cu<2+> are largely enhanced. Accordingly, the N-(2,4-dinitrophenyl)rhodamine B-hydrazide is suitable for high-selectivity and high-sensitivity detection of the Cu<2+>. The detection can be performed by a light absorption spectrum method and a fluorescence spectrum method.

This invention relates to compositions comprising haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma cells are haptenized with a dinitrophenyl group, and used for treatment of melanoma patients having metastatic disease. Preferably, patients are given a first vaccine dose containing haptenized cells to “prime” the immune system. Subsequently, patients are injected with an immunomodulatory compound such as cyclophosphamide. In a preferred embodiment, an appropriate time period after the “priming” vaccine dose, additional vaccine doses containing a mixture of haptenized cells and an adjuvant are administered. The described treatment plan is more effective for eliciting favorable anti-tumor immune responses.

The invention discloses structures of nitrophenyl-benzo[1,2,3] triazole, dinitrophenyl-benzo[1,2,3] triazole and a dinitrophenyl-benzo[1,2,3] triazole derivative, and mass spectrometry information thereof. In addition, the invention also discloses preparation methods for the nitrophenyl-benzo[1,2,3] triazole, the dinitrophenyl-benzo[1,2,3] triazole and the dinitrophenyl-benzo[1,2,3] triazole derivative. According to the preparation methods, novel compound structures of the nitrophenyl-benzo[1,2,3] triazole and the dinitrophenyl-benzo[1,2,3] triazole derivative are prepared, which can be applied to novel materials for the fields, such as energetic materials, oil exploitation and space exploration. Synthesis methods provided by the invention have the characteristics that raw materials are easy to obtain, the operation is simple and convenient, the safety is high, the process is controllable and the like.

The invention discloses a holarrhine alkaloid derivative and an application of holarrhine alkaloid derivative. The structure of the holarrhine alkaloid derivative disclosed by the invention is as general formula (I), wherein R represents substituted phenyl or substituted naphthyl and specifically represents the following groups: phenyl, paranitrophenyl, p-methyl phenyl, p-methoxy phenyl, 2,4-dichlorophenyl, p-chlorophenyl, 2,4-dinitrophenyl, 2-naphthyl, 1-naphthyl, 4-chlorine-1-naphthyl and methoxy phenyl. The invention further discloses an application of the holarrhine alkaloid derivative in preparation of a medicine for preventing and treating alzheimer's disease or a medicine for improving the intelligence.