30 results about "Atropine sulphate" patented technology

The disclosure provides a pharmaceutical composition for treating social anxiety, performance anxiety, and social phobia comprising a therapeutic amount for die treatment of a patient of a β-adrenergic receptor antagonist, an anti-diarrheal compound, and an optional anticholinergic compound. The β-adrenergic receptor antagonist may be the lipophilic β-blocker propranolol HCl, the anti-diarrheal compound may be the opioid diphenoxylate HCl, and the optional anticholinergic compound may be atropine sulfate. The composition for treating performance anxiety and social phobia can further include a pharmaceutically acceptable carrier. A method of preventing or treating social anxiety, performance anxiety, and social phobia in a patient is also provided, comprising administering a composition of the disclosure to a patient in need of such treatment. The composition administered in the present method comprises a therapeutic amount of a β-adrenergic receptor antagonist, an anti-diarrheal compound, and an optional anticholinergic compound.

The invention provides a preparation method of a belladonna extract. The preparation method comprises the following steps: (A) soaking coarse powder of belladonna herb in ethanol, percolating the coarse powder, filtering the percolate and carrying out evaporation concentration on the filtrate, thus obtaining first thick paste; (B) adding water to dilute residual substances after filtration, adjusting the PH value to acidity, then separating upper chlorophyll, collecting lower clear liquor, adjusting the PH value to alkalinity and concentrating the clear liquor, thus obtaining second thick paste; (C) mixing the first thick paste with the second thick paste, thus obtaining the belladonna extract. The content of atropine sulfate in the belladonna extract obtained by adopting the preparation method is between 9.8mg / ml and 10mg / ml. The belladonna extract has the advantages that the belladonna extract has good effects and high purity; all the indexes meet the corresponding requirements of the national formulary and even outclass the effects superior to the quality indexes stipulated in the formulary.

The invention provides a method for improving the stability of a low-concentration atropine ophthalmic preparation. The method is characterized in that an atropine sulfate bulk drug has a total impurity content of no more than 0.25% and / or a single impurity content of no more than 0.05%. The invention also provides a method for preparing the ophthalmic preparation, the atropine ophthalmic preparation prepared by using the method, and an application of the atropine ophthalmic preparation in preparation of drugs used for preventing and / or treating visual defects.

The present invention discloses an ophthalmic pharmaceutical composition. The ophthalmic pharmaceutical composition comprises 0.01-1wt% of atropine sulfate; the pH value of the ophthalmic pharmaceutical composition is 3.5-4.0; and the osmotic pressure is 180 to 300 mOsm / kg. The pharmaceutical composition can obviously improve the related substance problems which are not easy to solve in the priorart; and the composition is simple in component and not prone to forming agglomerates with the micron level or above, so that the corneal penetrability of atropine sulfate molecules can be improved.

The invention discloses a preparation method of atropine sulphate and solves the problem that an intermediate alpha-formoxyl phenylacetic acid tropeine is incompletely hydrolyzed in sulfuric acid and poor in hydrolysis effect in a single solvent, and an atropine crude product salt forming process is tedious in operation. The preparation method specifically comprises the following steps: I, adding potassium borohydride into a mixture containing alpha-formoxyl phenylacetic acid tropeine, alcohol and chloroform; II, adding an appropriate amount of water into the mixture and separating out an organic layer; III, distilling the organic layer to recover chloroform so as to obtain a faint yellow oily liquid; IV, adding acetone into the faint yellow oily liquid for freezing crystallization to obtain an atropine crude product; V, dropwise adding sulfuric acid into a solution containing the mixed solvent and the atropine crude product to adjust the pH of the solution to be greater than 4 but less than 7 at the temperature of 5 DEG C below zero to 10 DEG; VI, freezing the mixture overnight and crystallizing, filtering and drying to obtain atropine sulphate white crystals. The preparation method disclosed by the invention not only greatly improves the content and molar yield of the atropine sulphate crude product, but also lowers the cost to a great extent, and further has the characteristics of being simple and convenient to operate.

The invention provides a low-concentration atropine sulfate eye drop and a preparation method thereof. The low-concentration atropine sulfate eye drop is 1000ml of 0.004 percent of atropine sulfate eye drop, prepared from 40mg of atropine sulfate, 9g of sodium chloride and an appropriate amount of injection water. The preparation method of the low-concentration atropine sulfate eye drop comprisesthe following steps: dissolving the sodium chloride and the atropine sulfate to obtain a dissolved solution; filtering the dissolved solution; adding the injection water from an automatic filter to reach 1000ml; performing sterilization and filtration; aseptically subpackaging an obtained solution into eye drop tubes which has functions of multiple dosage, single direction and sterile air filtration. The 0.004 percent of atropine sulfate eye drop is suitable for treating myopia spuria and extending treatment time, and also can be used for treating low true myopia in teenagers; and meanwhile, the multi-dose preservative-free eye drop has the advantages of being low in production cost and being economic in using, and can effectively avoid damage of ocular surfaces caused by preservatives.

The invention provides a synthesis method of atropine and atropine sulfate, which comprises the following steps: carrying out acetylation reaction on tropine acid to form acetyl tropine acid, reactingthe acetyl tropine acid with a chlorination reagent to form acyl chloride, reacting the acyl chloride with tropine alcohol, removing acetyl to obtain atropine, and salifying atropine and sulfuric acid to obtain atropine sulfate. The whole synthesis process can be completed by adopting a one-pot reaction, additional steps for completing the process by isolating intermediates are avoided, the reaction conditions are mild, the steps are simple, the yield is high, the purity is high, and the method is suitable for large-scale industrial production.

The invention relates to a preparation prescription and a technology of a compound diphenoxylate tablet. Every ten thousand compound diphenoxylate tablets comprise the following raw and auxiliary materials: 25g of diphenoxylate hydrochloride, 0.25g of atropine sulphate, 152-168g of starch, 522.5-577.5g of lactose, 47.5-52.5g of calcium hydrogen phosphate, 76g-84g 40 percent (ml / ml) of ethanol and 6.65-7.35g of magnesium stearate. The compound diphenoxylate tablet has better dissolution rate and content homogeneity.

The invention discloses a sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry. The compound composition is characterized by comprising raw materials of, by weight, 3-15 parts of lactic acid ciprofloxacin, 0.02-0.2 part of atropine sulfate, 20-70 parts of sticktight, 20-40 parts of rhizoma atractylodis, 8-20 parts of dark plum and 5-10 parts of myrobalan. The compound composition is prepared by mixing well the raw materials according to the proportion. An addition into an animal fodder is 0.1%-0.8%. The composition of the invention can kill bacteria rapidly and alleviate diarrhoea symptom caused by bacteria rapidly, has good protective effect on intestinal tract and overcomes disadvantages of a simple western medicine, such as long curative effect, weak curative effect, slow symptom alleviation and disadvantage of slow effect performance of a simple traditional Chinese medicine; besides, usage of the composition has low medicine cost and creates high benefit for farmers. The composition can be prepared into a powder, an oral liquid, a particulate agent and a tablet.

The invention discloses a compound poplar flower oral liquid for treating piglet yellow or white dysentery and a preparation thereof, and aims to provide the compound poplar flower oral liquid which has a quick response to piglet yellow or white dysentery treatment, is effective and efficient and can reduce the drug resistance generated by bacteria and treat both symptoms and root causes, and thepreparation method which has a simple process and is easy to implement. Each 100 liters of the oral liquid comprises the following components by mass: 1 to 10 kilograms of poplar flower extract, 1 to10 kilograms of colistin sulfate, 0.05 to 0.5 kilogram of atropine sulfate, 0.01 kilogram of EDTA-2Na, 0.6 kilogram of sodium benzoate, and the balance of water. The compound poplar flower oral liquidis a compound preparation adopting the combination of Chinese medicaments and western medicaments, wherein the poplar flower and the colistin sulfate have a dual antibacterial effect; the atropine sulfate inhibits glandular secretion of intestinal tracts to reduce the water content of intestinal contents and can effectively reduce the drug resistance probability of escherichia coli; and thus, thecompound poplar flower oral liquid has a quick response to the piglet yellow or white dysentery treatment, is effective and efficient, and can obviously reduce the piglet death rate and improve the cure rate.

The invention relates to a compound maquindox injection for veterinary use and a preparation method thereof. The injection is made from maquindox, atropine sulfate, organic solvent and water. As a special compound preparation for veterinary use, the injection has special efficacy on severe diseases caused by treponema such as swine dysentery, piglet yellow dysentery, white dysentery, calf diarrhea, paratyphoid, bacterial enteritis, and the like, and has the advantages of convenient use, short treatment course, low drug resistance, and the like.

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of atropine sulfate. The preparation method comprises the following steps: firstly preparing tropine ester, then preparing atropine, salifying to prepare atropine sulfate, and finally refining to obtain the product. In the preparation process of the tropine ester, the reaction temperature is strictly controlled to be 105-111 DEG C, and the crystallization temperature is controlled to be 0-5 DEG C, so that the yield of the tropine ester is improved. In the process of preparing atropine through reduction reaction, palladium-carbon is adopted as a catalyst, and the reaction temperature is strictly controlled to be 10-15 DEG C, so that the product quality is effectively improved. Sulfuric acid is diluted by preparing a sulfuric acid ethanol solution, and the dripping speed of the sulfuric acid ethanol solution is controlled, so that the stable quality of atropine sulfate is ensured.

Hypertrophic pyloric stenosis can be treated by suppressing contraction of the pyloric muscle by using a therapeutic agent or a treatment kit which comprises atropine sulfate as an anticholinergic agent and nitroglycerin or isosorbide nitrate as an NO donor as the active ingredients.

The invention discloses a western medicine compound pharmaceutic preparation for treating diphtheritic enteritis. A Chinese medicine preparation comprises, by weight, 2-8 parts of dragon bones, 5-15 parts of fructus chebulae, 2-8 parts of nutmeg, 1-9 parts of honey-fried licorice roots, 5-15 parts of red halloysite, 5-13 parts of dogwood, 2-9 parts of szechwan Chinaberry fruits, 5-15 parts of rhizoma alismatis, 5-15 parts of elecampane and 1-9 parts of coptis chinensis. The western medicine preparation comprises, by weight, 0.1-0.5 part of diphenoxylate, 0.1-0.5 part of atropine sulphate, 0.8-1.2 parts of pectinesterase and 0.01-0.08 part of medicinal magnesium chloride. In the Chinese medicine preparation, the added components have the effects of warming the middle and benefiting qi, invigorating spleen and removing dampness and the like. The added western medicine preparation is obvious in sterilization effect, contributes to growth of an intestinal tract normal flora, and has an obvious curative effect on the diphtheritic enteritis, and the effect is quick.

The invention provides an atropine sulfate injection with improved stability, which belongs to the technical field of pharmaceutical preparations and comprises 0.5 mg / ml of atropine sulfate, 9mg / ml of sodium chloride, 0.1-0.15 mg / ml of edetate disodium, a proper amount of hydrochloric acid and the balance of water for injection. According to the atropine sulfate injection with the improved stability, the problem that the stability of a traditional prescription is poor is solved, the impurity content can be greatly reduced, and the stability of the atropine sulfate injection is greatly improved.

The invention discloses an ophthalmic pharmaceutical composition comprising 0.01-1 wt% of atropine sulfate, and the pH value of the ophthalmic pharmaceutical composition is 3.5-4.0; and the osmotic pressure is 180 to 300 mOsm / kg. The pharmaceutical composition can obviously improve the problem of related substances which is not easy to overcome in the prior art; and the composition is simple in component, is not easy to form agglomerates of micron order or above, and is beneficial to improving the corneal penetrability of atropine sulfate molecules.

The invention relates to a compound medicine for treating gastro spasm. The compound medicine is prepared from 1.5-6% of atropine sulphate, 5-12% of furazolidone and 40-94% of terramycin hydrochloride, wherein 0.3-1.2 g of the medicine is taken each time. The compound medicine is low in price, simple in making technology, short in medicine taking time, capable of achieving a remarkable curative effect and high in curative rate.

The invention discloses a sticktight-containing compound composition for treating bacterial diarrhoea of livestock and poultry. The compound composition is characterized by comprising raw materials of, by weight, 3-15 parts of lactic acid ciprofloxacin, 0.02-0.2 part of atropine sulfate, 20-70 parts of sticktight, 20-40 parts of rhizoma atractylodis, 8-20 parts of dark plum and 5-10 parts of myrobalan. The compound composition is prepared by mixing well the raw materials according to the proportion. An addition into an animal fodder is 0.1%-0.8%. The composition of the invention can kill bacteria rapidly and alleviate diarrhoea symptom caused by bacteria rapidly, has good protective effect on intestinal tract and overcomes disadvantages of a simple western medicine, such as long curative effect, weak curative effect, slow symptom alleviation and disadvantage of slow effect performance of a simple traditional Chinese medicine; besides, usage of the composition has low medicine cost and creates high benefit for farmers. The composition can be prepared into a powder, an oral liquid, a particulate agent and a tablet.

The invention discloses a compound florfenicol powder for treating mycoplasma of pigeon and a preparation method thereof, and the objective of the invention is to provide a compound florfenicol powder, which has instant effect for treating ycoplasma of pigeon and has effect for secondary infection of bacteria, and a preparation method which is simple and easy to be realized. Florfenicol in powderis 2-10 wt%, oxytetracycline is 2-12%, atropine sulfate is 0.05-0.5%, doxofylline 0.2-1.5%, and the rest is anhydrous dextrose. Florfenicol and oxytetracycline kill pathogen, which reduces probabilityof drug tolerance; atropine sulfate controls secretion of the digestive tract gland; doxofylline suppresses cough and calms panting. The four ingredients use together has a combination and cooperation function, and can quickly treat disease against clinical symptoms of mycoplasma disease of pigeon and accelerate recovery of pigeon, and has the efficacies for seeking both temporary and permanent solution, simultaneously preventing and treating other bacteria secondary infections, reducing drug tolerance probability, and considerably improving cure rate.

The invention belongs to the field of monitoring on animal internal secretion and provides an external secretion monitoring method which includes that atropine sulphate is injected into animal muscles, animals are subjected to general anesthesia, and the pancreas and the duodenum are sought; the section of the duodenum where the pancreatic duct of the pancreas is located is cut, a T-shaped pipe is inserted and two ends of a seprated duodenum section are sewed; two ends of the remained duodenum are subjected to intestinal anastomosis, another T-shaped pipe is inserted on the downstream of the intestinal anastomosis position, and a purse string suture is sewed surrounding the T-shaped pipe; and pipe openings of the two T-shaped pipes are clamped through a pair of haemostatic forceps and taken out, and peritoneum, compartment muscles and skins are sewed. According to the external secretion monitoring method, pancreatic secretion of living animals is monitored, influence of other factors on various enzymatic activities of pancreatic secretion is removed to the maximum extent, simultaneously after pancreatic secretion samples are collected, remained pancreatic secretion can flow back to the duodenum, and operation of a dairy cow digestive system is restored as far as possible. The external secretion monitoring method avoids slaughtering, saves test cost, and monitors external secretion functional changes of dairy cow pancreases in real time.

The invention relates to a measurement method for the content of atropine sulfate in traditional Chinese medicine suppository containing belladonna liquid extract. The invention solves the problem that only the existence of atropine sulfate in traditional Chinese medicine suppository containing belladonna liquid extract the traditional can be detected in the field of traditional Chinese pharmacy,and the content of the atropine sulfate cannot be detected. In the method, chromatograph conditions are controlled, comparison product and test article solutions are prepared, the comparison product solution and the test article solution are respectively absorbed, and the content of the atropine is measured by a high performance liquid chromatography method by adopting an external standard methodby using a liquid chromatograph. The content of the atropine can be precisely measured. The main peak and front and back separation effect is good, and the number of theoretical plates is high. The invention has important meaning for controlling the quality of the traditional Chinese medicine suppository.

The invention discloses refreshing and moisturizing cream and a preparation method thereof. The refreshing and moisturizing cream is prepared from the following raw materials in parts by weight: 50-70 parts of Chinese angelica, 30-80 parts of seaweed meal, 40-50 parts of surfactant, 20-30 parts of ammonium sulfate, 45-65 parts of cocinic acid, 40-90 parts of propanetriol, 10-50 parts of atropine sulphate, 55-70 parts of xylobiose, 10-20 parts of isostearyl, 40-60 parts of sodium aliphatate, 65-90 parts of sodium chloride and 5-10 parts of phenolic antioxidant. The preparation method of the refreshing and moisturizing cream comprises the following steps: soaking Chinese angelica in 95% ethyl alcohol for 1-2 days, filtering to obtain medicinal liquor for later use, recycling ethyl alcohol by adopting a waterproof distillation method, reacting at the temperature of 50-60 DEG C for 10-20 minutes, preparing liquid medicine for later use, and grinding Chinese angelica into powder for later use; pouring the rest components into the medicinal liquor, heating, uniformly stirring, and cooling; and adding Chinese angelica powder and seaweed meal, and uniformly stirring. The refreshing and moisturizing cream has the advantages that moisture content of skin can be increased by 21%, and hydrating degree of the skin can be maintained for one hour and is almost constant.

The invention discloses a preparation method of atropine sulphate and solves the problem that an intermediate alpha-formoxyl phenylacetic acid tropeine is incompletely hydrolyzed in sulfuric acid and poor in hydrolysis effect in a single solvent, and an atropine crude product salt forming process is tedious in operation. The preparation method specifically comprises the following steps: I, adding potassium borohydride into a mixture containing alpha-formoxyl phenylacetic acid tropeine, alcohol and chloroform; II, adding an appropriate amount of water into the mixture and separating out an organic layer; III, distilling the organic layer to recover chloroform so as to obtain a faint yellow oily liquid; IV, adding acetone into the faint yellow oily liquid for freezing crystallization to obtain an atropine crude product; V, dropwise adding sulfuric acid into a solution containing the mixed solvent and the atropine crude product to adjust the pH of the solution to be greater than 4 but less than 7 at the temperature of 5 DEG C below zero to 10 DEG; VI, freezing the mixture overnight and crystallizing, filtering and drying to obtain atropine sulphate white crystals. The preparation method disclosed by the invention not only greatly improves the content and molar yield of the atropine sulphate crude product, but also lowers the cost to a great extent, and further has the characteristics of being simple and convenient to operate.

The invention provides an establishing method for a rabbit sinus node chronic injury model. The method comprises the following steps of: after anaesthetizing a rabbit, fixing the back of the rabbit on a rabbit table, and recording body surface electrocardiogram; shaving the skin at a colpus area, longitudinally opening the chest along a third rib at the right side of sternum, separating epidermis and muscular tissues layer by layer, cutting off the third rib of the right side, and opening pericardium through mediastinum to expose auricula dextra; placing an electrode connected with an electrocardiogram V1 lead to a near sinus node area of the rabbit and slowly moving, when the electrocardiogram displays electrograph characteristics of the sinus node area, applying 20% formaldehyde solution to the electrode area, when the heart rate of the rabbit is decreased to 50-70% of original heart rate, intravenously injecting 2mg of atropine sulphate until the heart rate stops rising, and stopping applying formaldehyde solution; and cleaning the chest, closing the chest layer-by-layer, and feeding for later use. The invention also provides a sinus node targeted injection penetration electrode for implementing the method. Compared with the prior art, the establishing method is high in modeling success rate, stable in model and good in feasibility and repeatability..

The invention discloses an injection for treating swine dysentery and a preparation method thereof, aiming to provide an injection for treating swine dysentery that has quick effect, reduces the frequency and dose of medication, and reduces the occurrence of excessive drug residues for treating swine dysentery. The injection and its process are simple and easy to realize preparation method. Each 100L injection includes: acetylmequine 0.5-10kg, lincomycin hydrochloride 1-10kg, sodium bisulfite 0.2kg, sodium salicylate 1.5-30kg, EDTA-2Na 0.01kg, atropine sulfate 0.2kg, the balance For injection water. The present invention is a compound preparation using antibacterial drugs and antibiotics in combination. Acetamequin and lincomycin hydrochloride are used in combination, and adopt double effects to double inhibit Treponema hyodysenteriae, reduce the probability of bacterial drug resistance, and increase the incidence of swine dysentery. The sensitivity of Treponema, together with the inhibition of the secretion of intestinal digestive glands by atropine sulfate, reduces the amount of intestinal water during the disease of pigs, and the treatment of swine dysentery is effective.

The present invention discloses a Chinese medicine composition with the action of stopping drugs and its preparation method. It is made up by using the Chinese medicinal materials of ginseng, corydalis tuber, sea horse, dandelion, jinniucao, artificial bovine bezoar, datura flower and pearl according to a certain ratio. Said invention also discloses a quality control method of said Chinese medicine composition, including identification of tetrahydropalmatine, coffic acid, scopolamine and atropine, cholic acid and deoxycholic acid and content determination of ginsenoside Rg1, ginsenoside Re and scopolamine.

The invention belongs to the field of chemical synthesis, and in particular relates to a preparation method of atropine sulfate. First prepare tropin ester, then prepare atropine, then make salt to obtain atropine sulfate, and finally obtain the product through refining. In the process of preparing tropin ester, the reaction temperature is strictly controlled at 105-111°C, and the crystallization temperature is 0-5°C, so as to improve the yield of tropin ester. In the process of preparing atropine by reduction reaction, palladium carbon is used as a catalyst, and the reaction temperature is strictly controlled at 10-15° C. to effectively improve the product quality. Dilute the sulfuric acid by preparing it into a sulfuric acid ethanol solution, control its dropping rate, and ensure the stable quality of atropine sulfate.