30 results about "3-Hydroxyhexanoate" patented technology

Methods for engineering transgenic organisms that synthesize polyhydroxyalkanoates (PHAs) containing 3-hydroxyhexanoate as comonomer have been developed. These processes are based on genetically engineered bacteria such as Escherichia coli or in plant crops as production systems which include PHA biosynthetic genes from PHA producers. In a preferred embodiment of the method, additional genes are introduced in wild type or transgenic polyhydroxybutyrate (PHB) producers, thereby creating new strains that synthesize 3HH monomers which are incorporated into PHAs. The 3HH monomer preferably is derived in microbial systems using butanol or butyrate as feedstocks, which are precursors of 3-hydroxyhexanoyl-CoA. Pathways for in vivo production of butyrol-CoA specifically encompassing butyryl-CoA dehydrogenase activity are provided.

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx / PLA (Poly Lactic Acid) monofilament fiber and a PHBV / PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

An objective of the present invention is to provide a biodegradable polyester fiber which has excellent thermal stability and excellent fiber strength. Another objective of the present invention is to provide a method for producing a biodegradable polyester fiber which has excellent mechanical properties, especially excellent thermal stability. The present invention relates to a biodegradable polyester fiber which is composed of a poly(3-hydroxybutylate-co-3-hydroxyhexanoate) that has a 3HH molar fraction of 2-9% by mole. The present invention also relates to a method for producing the biodegradable polyester fiber, which is characterized by comprising a fiber formation step wherein a poly(3-hydroxybutylate-co-3-hydroxyhexanoate) is formed into fibers at a temperature that is not less than the glass transition temperature of the poly(3-hydroxybutylate-co-3-hydroxyhexanoate) but not more than 70 DEG C during the melt extrusion of the poly(3-hydroxybutylate-co-3-hydroxyhexanoate).