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50results about How to "Synthetic method is economical" patented technology
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Preparation method and application for phosphine-oxazoline ligand, and ionic metal complex, enantiomer or racemate thereof
InactiveCN102875601AThe synthesis method is simpleSynthetic method is economicalOrganic compound preparationGroup 5/15 element organic compoundsPlanar chiralityStructural formula
The invention discloses a preparation method and an application for phosphine-oxazoline ligand, and ionic metal complex, enantiomer or racemate thereof. The ligand and the ionic metal complex thereof have the following structural formulas. The phosphine ligand related by the invention employs biphenyl as a skeleton, and realizes completely transmission from planar chirality to axial chirality through an asymmetric desymmerization. The synthetic method is simple and economic, omits a common and complex chiral separation process in the preparation of the chiral ligand. The obtained chiral ligand has the advantages of high reactive activity, good enantiomorphous selectivity and the like in a model reaction.
Owner:SUN YAT SEN UNIV
Phosphine ligand and enantiomer or racemic body thereof and preparation methods thereof
ActiveCN102532196AHigh reactivityHigh enantioselectivityOrganic-compounds/hydrides/coordination-complexes catalystsGroup 5/15 element organic compoundsIridiumSynthesis methods
The invention discloses a phosphine ligand and an enantiomer or a racemic body thereof and preparation methods and applications thereof. The structural formulae of the phosphine ligand and the enantiomer or the racemic body are shown in the specifications; a phosphine ligand compound has a novel framework; complete transfer of planar chirality to axial chirality in a synthesis process is realized through a desymmetrization reaction; a synthesis method is simple and economical; during preparation of a chiral ligand, common complex chiral splitting processes are avoided; and an obtained chiral ligand has the advantages of high reaction activity, high enantioselectivity and the like in a model reaction, can be applied to catalytic reactions of a plurality of metals such as palladium, rhodium, nickel, copper, iridium, ruthenium, iron, cobalt, gold, platinum and the like, and can have a very good catalytic effect.
Owner:SUN YAT SEN UNIV
Method for synthesizing carbon quantum dots on basis of amino acids and iron ions
InactiveCN105838363AHigh fluorescence intensityThe synthesis method is simple and controllableLuminescent compositionsWater bathsSynthesis methods
The invention provides a method for synthesizing carbon quantum dots on the basis of amino acids and iron ions, belonging to the field of preparation of fluorescent nano materials. The method comprises the following steps: oscillating and mixing a mixed solution of iron nitrate and amino acid in a mole ratio of 1:(5-10), and heating to react in an 80-DEG C water bath; and after the reaction finishes, naturally cooling to room temperature, dialyzing and filtering to obtain the carbon quantum dot water solution. The added iron nitrate can enhance the fluorescence intensity of the carbon quantum dots synthesized from tryptophan; and particularly, it is detected that only iron ions have such effects at present. By using accessible tryptophan as the carbon source, the iron ions are doped on such basis to synthesize the high-fluorescence carbon quantum dots. The synthesis method is controllable, simple and economical.
Owner:DALIAN UNIV OF TECH
Triethylene diamine synthesis method
InactiveCN107163054AImprove universalityRaise the ratioOrganic chemistryMolecular sieve catalystsAlkaline earth metalSynthesis methods
The invention discloses a triethylene diamine synthesis method, which comprises the following steps of performing preheating gasification on a water solution of raw materials; then, at 180 to 400 DEG C, performing contact reaction with modified molecular sieve catalysts to obtain triethylene diamine, wherein the modified molecular sieve catalysts are obtained by soaking HZSM type molecular sieves into a water solution of alkaline earth metal compounds and then performing drying and roasting; the raw materials are at least one kind of materials from piperazidine, piperazidine derivatives, straight chain alcohol amine and amines. The molecular sieve catalysts are modified through the alkaline earth metal, so that the acidity and the acid size of Brphinsted acid on the surfaces of the molecular sieve catalysts are obviously reduced; the proportion of the Lewis acid sites is improved; the reaction temperature is greatly lowered; the universality of the catalysts is good; the product yield is improved. Compared with a conventional triethylene diamine synthesis method, the triethylene diamine synthesis method achieves economic effects, green effects and high efficiency.
Owner:SHAOXING XINGXIN CHEM
Phosphoramidite ligand as well as preparation method and application thereof
ActiveCN104610363AHigh reactivityHigh enantioselectivityGroup 5/15 element organic compoundsOrganic-compounds/hydrides/coordination-complexes catalystsIridiumCatalytic effect
The invention relates to the field of chemical catalysis and discloses a phosphoramidite ligand as well as a preparation method and an application thereof. The synthesized phosphoramidite ligand and an enantiomer or a racemate of the phosphoramidite ligand take biphenyl as a framework and are subjected to an asymmetric induced reaction of axial chirality to realize complete transfer from central chirality to axial chirality. A synthetic method for the phosphoramidite ligand and the enantiomer or the racemate of the phosphoramidite ligand is simple and economic, and a common and complex chiral resolution process is avoided during chiral ligand preparation. The phosphoramidite ligand and the enantiomer or the racemate of the phosphoramidite ligand is employed to form the ligand together with active metal-iridium for catalyzing an asymmetric addition reaction of N-protected isatin and arylboronic acid, a very good catalytic effect is achieved, and a product can obtain the yield of more than 96% and the enantiomeric excess (ee) value of more than 92%.
Owner:SUN YAT SEN UNIV
Sanguinarine derivatives and synthesis method and use thereof
InactiveCN102010417AExcellent inhibitory activity against rice sheath blightResidue reductionBiocideOrganic chemistryRhizoctonia solaniRaw material
The invention relates to sanguinarine derivatives and a synthesis method and use thereof. In the invention, 5-isopropoxy-5,6-dihydrosanguinarine, 5-p-methylphenylamino-5,6-dihydrosanguinarine and 5-benzylamino-5,6-dihydrosanguinarine are synthesized by using sanguinarine as a raw material under different conditions. The bactericidal activities of the three compounds are measured at different concentrations, and corresponding EC50 values are calculated. Compared with the conventional bactericide, the sanguinarine derivatives have the characteristics of high degradability, low residue and the like and can be synthesized by a simple and economic method. Thus, the sanguinarine derivatives are valuable bactericide pilot compounds and can be used for preventing and controlling rhizoctonia solani.
Owner:NANKAI UNIV
Method for synthesizing 3,5-disubstituted pyrazole
The invention relates to a practical synthetic method for 3, 5-disubstituted pyrazole, and the method solves the defects of long reaction time, large consumption of alkyne, low yield and being difficult to synthesize great amount of compounds of the existing method. The technical proposal is as follows: aldehyde compounds which are dissolved into a solvent react with sulfonyl hydrazine compounds, thus obtaining diazo compounds, then the diazo compounds react with alkyne under alkali and the 3, 5-disubstituted pyrazole is obtained. The method is characterized in that the solvent is toluene, the mol ratio of the aldehyde compounds and the sulfonyl hydrazine compounds in the first step of the reaction is 1; the alkali added in the second step is NaOH aqueous solution, the content of NaOH has the same valent weight with the hydrazine; 1.5 valent weight of diazo compounds are added in the third step, and pure target product is obtained by conventional processing after the reaction.
Owner:上海药明康德新药开发有限公司
Method for synthesizing 5-methyl-5-propyl-1,3-dioxane-2-ketone and carisoprodol
InactiveCN101289441AIncrease profitReduce consumptionCarbamic acid derivatives preparationOrganic compound preparationKetoneIsopropylamine
The invention discloses a synthetic method for 5-methyl-5-propyl-1, 3-dioxane-2-ketone and carisoprodol, which uses 2-methyl-2-propyl-1, 3-propanediol as an original material, and the 5-methyl-5-propyl-1,3-dioxane-2-ketone can be generated through a condensation reaction with urea under the catalysis of activated metal oxide; the obtained 5-methyl-5-propyl-1, 3-dioxane-2-ketone is ammonolyzed with isopropylamine, and 2-methyl-2-ethyl-3-hydroxypropyl-N-isopropylcarbamate can be prepared; the 2-methyl-2-ethyl-3-hydroxypropyl-N-isopropylcarbamate reacts with sodium cyanate, and the carisoprodol is prepared. The synthetic method for the 5-methyl-5-propyl-1, 3-dioxane-2-ketone and the carisoprodol is cheap and easily available in raw material, simple in preparation technology and more economical.
Owner:CHONGQING ENSKY CHEM
Green method of enzymatic synthesis of cefaclor
InactiveCN106222230AHigh selectivityImprove catalytic performanceImmobilised enzymesHydrolasesChemical synthesisEnzymatic synthesis
The invention relates to a green method of enzymatic synthesis of cefaclor. The method includes the steps of: (S1) adding a parent nucleus 7-ACCA into a buffer liquid; (S2) under the pH of 5-8, adding a D-p-hydroxyphenylglycinate derivative or a salt thereof and / or D-p-hydroxyphenylglycine amide, and immobilized cefaclor synthesis enzyme, and performing a reaction for 1-3 h at 5-30 DEG C under the pH value of 6.2-7.8; after a certain reaction time, adding a seed crystal to perform crystallization, and when the reaction is finished, separating a reaction liquid and the immobilized cefaclor synthesis enzyme to obtain a cefaclor coarse product; and (S3) acid-hydrolyzing and dissolve-clarifying the coarse product, filtering and re-crystallizing the product to prepare the cefaclor. The enzymatic synthesis method, compared with a conventional chemical synthesis method, is simple in operation, is low in cost, reduces synthetic period, improves production efficiency and total yield, has strong controllability and satisfies industrial production.
Owner:GUANGZHOU BAIYUNSHAN PHARM CO LTD
Preparation method for orange red fluorescent copper nanocluster based on L-methionine
ActiveCN110508828APromote growthImprove stabilityTransportation and packagingMetal-working apparatusNorfloxacinQuenching
The invention provides a preparation method for an orange red fluorescent copper nanocluster based on L-methionine. The preparation method comprises the following steps that by taking L-methionine asa protective agent and copper salt as a metal precursor, hydrogen peroxide is added to serve as an activating agent, hydrazine hydrate serves as a reducing agent, an orange red fluorescent copper nanocluster (Cu NCs) with good stability is prepared, the maximum excitation wavelength is 337 nm, the maximum emission wavelength is 592 nm, the stokes shift is up to 255 nm, and the structure is denotedas Cu NCs / Met. The synthetic method is novel, economical and easy to implement. According to the fluorescence quenching phenomenon, the Cu NCs / Met can be used as a fluorescent nanometer probe and isapplied to high-sensitivity and high-selectivity detection of norfloxacin medicines, and the detection process is simple and rapid. The fluorescent nanocluster prepared by the method has huge application prospects in the fields of sensing, catalysis, photoelectric devices, anti-counterfeiting, cell imaging, drug delivery and the like.
Owner:HUAIBEI NORMAL UNIVERSITY
Heterogeneous core-shell g-C3N5@MnO2 complex and preparation method thereof
ActiveCN112221531AThe synthesis method is simpleSynthetic method is economicalPhysical/chemical process catalystsVacuum dryingPhoto catalysis
The invention discloses a heterogeneous core-shell g-C3N5@MnO2 complex, which takes rod-like g-C3N5 as an inner core, wherein MnO2 nanosheets are compounded on the surface of the inner core, and the heterogeneous core-shell g-C3N5@MnO2 complex has excellent photocatalytic performance and photoelectrocatalytic performance. The invention also discloses a preparation method of the heterogeneous core-shell g-C3N5@MnO2 complex, wherein the method comprises the following steps: uniformly mixing rod-like g-C3N5, KMnO4 and water, transferring the obtained mixed solution into a polytetrafluoroethylenereaction kettle, sealing the polytetrafluoroethylene reaction kettle, and carrying out hydrothermal reaction in a vacuum drying oven; and cooling the reaction kettle to room temperature, washing the obtained reaction solution with water, centrifuging to remove the supernatant, and drying the obtained dark brown precipitate to obtain the heterogeneous core-shell g-C3N5@MnO2 complex. The preparationmethod has the characteristics of simple operation, low cost, environmental protection, no need of complex post-treatment steps, no need of additional addition of a reducing agent, easiness in large-scale preparation and the like.
Owner:CHANGSHA UNIVERSITY
Rare earth metal organic framework material with antibacterial activity and preparation method thereof
ActiveCN111138680AGood antibacterial effectThe synthesis method is simpleAntibacterial agentsAgainst vector-borne diseasesEscherichia coliMetal-organic framework
The invention discloses a rare earth metal organic framework material with antibacterial activity and a preparation method thereof. The chemical formula of the rare earth metal organic framework material is C14H11N3O8Nd, and the rare earth metal organic framework material is prepared by taking 1, 4-bis (imidazole-1-yl) terephthalic acid, 2, 6-pyridine dicarboxylic acid and Nd(NO3)3.6H2O as raw materials and adopting a solvothermal method. The rare earth metal organic framework material prepared by the invention has a relatively strong bacteriostatic effect on escherichia coli (G-), so that therare earth metal organic framework material can be used for preparing a bacteriostatic agent for preventing and treating escherichia coli.
Owner:FUJIAN MEDICAL UNIV
Preparation method of CdTe/CdS/ZnS/SiO2 quantum dot
InactiveCN103773358ASynthetic method is fastThe synthesis method is simpleLuminescent compositionsPropanoic acidSilicic acid
The invention discloses a preparation method of a CdTe / CdS / ZnS / SiO2 quantum dot. The preparation method comprises the steps: firstly, synthesizing mononuclear CdTeQDs by using cadmium acetate, mercaptopropionic acid and sodium hydrogen telluride in a water phase; then, transferring a reaction solution of CdTeQDs which is cooled to room temperature into a precursor which contains cadmium acetate, zinc sulfate and the mercaptopropionic acid and has the pH value of 9.0-10.0, uniformly mixing and stirring, adding a sodium sulphide solution, and carrying out backflow reaction to synthesize double-shell CdTe / CdS / ZnSQDs; and finally, directly adding tetraethyl orthosilicate in a reaction solution of the CdTe / CdS / ZnSQDs, and carrying out backflow reaction to synthesize CdTe / CdS / ZnS / SiO2QDs. The preparation method is used for synthesizing the CdTe / CdS / ZnS / SiO2QDs by using a direct method and is simple to operate, needs mild conditions, and is low in cost and friendly to the environment. The synthesized product CdTe / CdS / ZnS / SiO2QDs is good in water solubility, high in stability, uniform in size and excellent in optical performance.
Owner:NANJING MEDICAL UNIV
Synthetic method of pyroglutamyl small peptide
InactiveCN101445550AExtensive synthesisAvoid yield lossPeptide preparation methodsSmall peptideOrganic solvent
The invention discloses a synthetic method of pyroglutamyl small peptide, relates to a synthetic method of pyroglutamyl small peptide and provides a synthetic method of pyroglutamyl small peptide which has low-price and easily obtained raw materials, high productivity, simple post treatment and is more suitable for large-scale production. 10mmol of pyroglutamyl diketopiperazine, 20 to 30mmol of amino acid or small peptide and 20 to 30mmol of alkaline organic solvent are added into a container which has a volume of 25mL and is provided with a reflux condensing pipe; the mixture is stirred at the temperature of 0 DEG C to 70 DEG C, reacts for a night, and then undergoes vacuum concentration and then column chromatography and purification to obtain the pyroglutamyl small peptide with the productivity of 20 percent to 85 percent.
Owner:XIAMEN UNIV
Europium-doped organic framework material, preparation method and applications thereof
ActiveCN111087415AStrong inhibitory activityThe synthesis method is simpleGroup 3/13 organic compounds without C-metal linkagesOrganic chemistry methodsTumor therapyPharmaceutical Substances
The invention discloses a europium-doped organic framework material, a preparation method and applications thereof, wherein the chemical formula of the organic framework material is C14H11N3O8Eu, andthe organic framework material is prepared by taking 1,4-bis(imidazole-1-yl)terephthalic acid, 2,6-pyridine dicarboxylic acid and Eu(NO3)3.6H2O as raw materials through a solvothermal method. The organic framework material prepared by the invention has obvious inhibiting effect on tumor cells, and has low toxicity to normal cells, so that the organic framework material is expected to be developedinto tumor treatment medicines.
Owner:FUJIAN MEDICAL UNIV
Application of 3-acetyl thiotetronic acid derivatives in bactericide for controlling phytopathogen
ActiveCN107079910AExcellent against apple rot pathogenEasy to degradeBiocideOrganic chemistryBipolaris zeicolaLead compound
The invention relates to application of 3-acetyl thiotetronic acid derivatives in bactericides for controlling phytopathogen. 3-acetyl thiotetronic acid is used as a raw material for synthesizing 3-acetyl-4-benzylidene thiotetronic acid, 3-acetyl-5-p-fluoro-benzylidene thiotetronic acid and 3-acetyl-5-p-trifluoromethyl benzylidene thiotetronic acid under different conditions. The bactericidal activities of the three compounds under different concentrations are measured and the corresponding EC50 values are computed. The 3-acetyl thiotetronic acid derivatives have superior activities in inhibiting bacteria of apple rot, leaf spot of corn, wheat scab and fusarium wilt of tomatoes, have the characteristics of easy degradation, low residual and the like as compared with traditional bactericides, have simple and economic synthetic methods, are lead compounds of bactericides of great value, and can be used for controlling apple rot, leaf spot of corn, wheat scab and fusarium wilt of tomatoes.
Owner:ANHUI AGRICULTURAL UNIVERSITY
Axial chirality monophosphine ligand in chiral bridging and preparation method thereof
ActiveCN106831862AHigh reactivityHigh enantioselectivityOrganic-compounds/hydrides/coordination-complexes catalystsCatalytic reactionsSynthesis methodsSuzuki reaction
The invention discloses an axial chirality monophosphine ligand in chiral bridging and a preparation method thereof. An optical pure ligand which has both chiral chains in bridging and axial chirality is obtained by using biphenyl as a framework through accurate chiral recognition and control, a synthesis method is simple and economic, separation and purification can be realized through a silica-gel column chromatography separation method, a complicated chiral resolution process is avoided, and the obtained chiral ligand has the advantages of high reaction activity, good enantioselectivity and the like in an investigative model reaction; particularly, the effect in an asymmetric Suzuki reaction of palladium-catalyzed bromo-heterocyclic aromatic and arylboronic acid is excellent.
Owner:SUN YAT SEN UNIV
Manganese-based coordination compound with anti-tumor activity
InactiveCN106946938AThe synthesis method is simpleGood antitumor activityAntineoplastic agentsGroup 7/17 organic compounds without C-metal linkagesChronic granulocytic leukemiaMonoclinic crystal system
The invention discloses a manganese-based coordination compound with anti-tumor activity. The chemical formula of the manganese-based coordination compound with anti-tumor activity is [Mn(C7H3NO4)*H2O; the molecular weight is 244.04; the manganese-based coordination compound is of a zero-dimenstional structure, and belongs to monoclinic system; space group is C2 / c; single cell parameters a=13.214(3) angstroms, b=9.7286 (19) angstroms, c=13.174(3) angstroms, alpha=gamma=90 DEG, beta=96.35(3) DEG, V=1683.2(6) angstrom<3>, and Z=8. The manganese-based coordination compound is prepared taking manganese acetate tetrahydrate and 2,6-pyridinedicarboxylic acid as raw materials via hydrothermal method. The preparation method is simple; cost is low; the obtained manganese-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the manganese-based coordination compound.
Owner:FUJIAN MEDICAL UNIV
Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule
ActiveCN109970697AThe synthesis method is simpleThe split method is green and efficientOrganic chemistry methodsSolventKetone
The invention relates to a synthetic method of a chiral spiro [chroman-4, 1'-indane] molecule. The method comprises the following steps of using phenylpropionic acid as a starting material to react with malonic acid monoethyl magnesium salt to obtain beta-ketone ester, constructing a spiro lactone structure through an acid catalysis series Friedel-Crafts reaction one-pot method, then activating phenol hydroxyl through triflate, finally removingan occupation atom and sulfonic ester group through palladium carbon hydrogenation to synthesizethe chiral spiro [chroman-4, 1'-indane] molecule. The optical resolution of a racemate is realized under the action of the N-benzyl halogenated cinchonine. The synthetic method solves the problems that an original method has poor atom economy, a pluralityof synthetic wastes and a low practical value, and realizes compact and economical large-scale preparation of target molecules; the resolution method is green and efficient, and resolution reagents and solvents can be used for a plurality of times; and the product molecules and the synthesis method have important application values and potentials in the aspects of catalyst framework design and natural product medicine synthesis.
![Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/d3ad3f8a-8649-46be-aaa6-f689d16d617b/FDA0002048279850000011.png "Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule")
![Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/d3ad3f8a-8649-46be-aaa6-f689d16d617b/FDA0002048279850000012.png "Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule")
![Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/d3ad3f8a-8649-46be-aaa6-f689d16d617b/FDA0002048279850000013.png "Synthetic method of chiral spiro [chroman-4, 1'-indane] molecule")
Owner:NANKAI UNIV
Synthesis method of N-diarylmethyl sulfonamide compound
ActiveCN111170899AEfficient synthesisBroad biological activitySulfonyl/sulfinyl group formation/introductionSulfonic acid amide preparationOrganic synthesisEthyl acetate
The invention discloses a synthesis method of an N-diarylmethyl sulfonamide compound, and belongs to the technical field of organic synthesis intermediates. According to the synthesis method, the N-diarylmethyl sulfonamide compound is synthesized by utilizing a cascade reaction; the method specifically comprises the following steps: (1) adding an aromatic aldehyde, a sulfonamide, trimethoxybenzeneor a derivative thereof, and Lewis acid into a reaction tube according to a molar ratio of 1.0: 1.0: 1.0: 0.1, and carrying out magnetic stirring reaction at room temperature for 8-24 hours by taking1, 2-dichloroethane as a solvent; and (2) after the reaction is finished, evaporating under reduced pressure to remove most of the solvent, and carrying out column chromatography separation and purification on a residual mixed solution by using petroleum ether and ethyl acetate in a volume ratio of (1: 1)-(2: 1) as leacheate to obtain the product. The N-diarylmethyl sulfonamide compound synthesized by the method has wide application in the fields of medicines, pesticides and the like. The synthesis method disclosed by the invention has the advantages of low cost, simplicity in operation, highyield, mild conditions and the like, and has a good application prospect.
Owner:内蒙古赤峰市柏善医药有限公司
Synthetic method of indanone and derivatives thereof
ActiveCN110028394AImprove compatibilityMild reaction conditionsPreparation by carbon monoxide reactionOrganic synthesisSynthesis methods
The invention discloses a synthesis method of indanone and derivatives thereof, which comprises the following steps: adding a dialkyl acetylene compound, a palladium catalyst, an additive and an inorganic base into a dry reaction container together, and replacing a gas atmosphere in the reaction container with carbon monoxide from air; adding an o-bromoiodobenzene compound and an anhydrous 1,4-dioxane solvent in a carbon monoxide gas atmosphere, heating to react, and cooling to room temperature; adding a saturated ammonium chloride solution for quenching reaction, adding water, extracting by using ethyl acetate, separating by column chromatography, and purifying to obtain indanone and derivatives thereof. The reaction raw materials are easy to obtain, and the reaction conditions are mild;according to the method, the defects that in a traditional preparation method, the raw materials are complex in structure and not easy to obtain and can be obtained through multiple steps are overcome, carbon monoxide serves as a direct source of carbonyl, three new C-C bonds are built in one reaction, and the method better conforms to the ideas of atom economy, synthesis step economy and green chemistry in organic synthesis.
Owner:NANJING UNIV OF POSTS & TELECOMM
Schiff base compound, preparation thereof and application of Schiff base compound in copper ion detection
ActiveCN108586382ASynthetic method is economicalLow priceOrganic chemistryMaterial analysis by observing effect on chemical indicatorSolventIon
The invention discloses a Schiff base compound, preparation thereof and an application of the Schiff base compound in copper ion detection. The preparation of the Schiff base compound comprises the steps of subjecting 3-benzothiazolyl-2-hydroxyl-5-bromobenzaldehyde and tri(hydroxymethyl)aminomethane, which are in the mole ratio of 1: (1 to 1.5), to heating refluxing for 10 to 15 hours in anhydrousmethanol at the temperature of 60 DEG C to 70 DEG C, carrying out suction filtration after the reaction ends, and washing solids, thereby obtaining the Schiff base compound. Schiff base test paper isobtained through dissolving the obtained Schiff base compound in a DMSO solvent, then, soaking filter paper in a DMSO solution, and carrying out drying. The Schiff base test paper is used for detecting copper ions in an aqueous solution, the sensitivity is high, the result is clear and recognizable, the operation is simple, convenient and quick, special instrument and equipment and professional training are not required, and thus, the popularization is facilitated.
Owner:SHANXI UNIV
Preparation method of cdte/cds/zns/sio2 quantum dots
InactiveCN103773358BSynthetic method is fastThe synthesis method is simpleLuminescent compositionsPropanoic acidSilicic acid
Owner:NANJING MEDICAL UNIV
Preparation method and application of phosphine-oxazoline ligand, ionic metal complex, enantiomer or racemate thereof
InactiveCN102875601BThe synthesis method is simpleSynthetic method is economicalOrganic compound preparationGroup 5/15 element organic compoundsCombinatorial chemistryStructural formula
The invention discloses a preparation method and an application for phosphine-oxazoline ligand, and ionic metal complex, enantiomer or racemate thereof. The ligand and the ionic metal complex thereof have the following structural formulas. The phosphine ligand related by the invention employs biphenyl as a skeleton, and realizes completely transmission from planar chirality to axial chirality through an asymmetric desymmerization. The synthetic method is simple and economic, omits a common and complex chiral separation process in the preparation of the chiral ligand. The obtained chiral ligand has the advantages of high reactive activity, good enantiomorphous selectivity and the like in a model reaction.
Owner:SUN YAT SEN UNIV
Application of 3-acetylthiotetronic acid derivatives in fungicides for controlling plant pathogens
ActiveCN107079910BExcellent against apple rot pathogenEasy to degradeBiocideOrganic chemistryAcid derivativePathogenic bacteria
Owner:ANHUI AGRICULTURAL UNIVERSITY
Method for synthesizing 3,5-disubstituted pyrazole
The invention relates to a practical synthetic method for 3, 5-disubstituted pyrazole, and the method solves the defects of long reaction time, large consumption of alkyne, low yield and being difficult to synthesize great amount of compounds of the existing method. The technical proposal is as follows: aldehyde compounds which are dissolved into a solvent react with sulfonyl hydrazine compounds,thus obtaining diazo compounds, then the diazo compounds react with alkyne under alkali and the 3, 5-disubstituted pyrazole is obtained. The method is characterized in that the solvent is toluene, the mol ratio of the aldehyde compounds and the sulfonyl hydrazine compounds in the first step of the reaction is 1; the alkali added in the second step is NaOH aqueous solution, the content of NaOH hasthe same valent weight with the hydrazine; 1.5 valent weight of diazo compounds are added in the third step, and pure target product is obtained by conventional processing after the reaction.
Owner:上海药明康德新药开发有限公司
Synthetic method of pyroglutamyl small peptide
InactiveCN101445550BExtensive synthesisAvoid yield lossPeptide preparation methodsRefluxOrganic solvent
The invention discloses a synthetic method of pyroglutamyl small peptide, relates to a synthetic method of pyroglutamyl small peptide and provides a synthetic method of pyroglutamyl small peptide which has low-price and easily obtained raw materials, high productivity, simple post treatment and is more suitable for large-scale production. 10mmol of pyroglutamyl diketopiperazine, 20 to 30mmol of amino acid or small peptide and 20 to 30mmol of alkaline organic solvent are added into a container which has a volume of 25mL and is provided with a reflux condensing pipe; the mixture is stirred at the temperature of 0 DEG C to 70 DEG C, reacts for a night, and then undergoes vacuum concentration and then column chromatography and purification to obtain the pyroglutamyl small peptide with the productivity of 20 percent to 85 percent.
Owner:XIAMEN UNIV
Preparation method of orange-red fluorescent copper nanoclusters based on l-methionine
ActiveCN110508828BPromote growthImprove stabilityTransportation and packagingMetal-working apparatusNorfloxacinFluorescent quenching
The invention provides a method for preparing orange-red fluorescent copper nanoclusters based on L-methionine. In the method, L-methionine is used as a protective agent, copper salt is used as a metal precursor, and hydrogen peroxide is added as a protective agent. The activator, hydrazine hydrate as the reducing agent, prepared orange-red fluorescent copper nanoclusters (Cu NCs) with good stability. The maximum excitation and maximum emission wavelengths were 337 and 592nm, respectively, and the Stokes shift was as high as 255nm. The structure was recorded as Cu NCs / Met. The synthesis method is novel, economical and easy. According to the fluorescence quenching phenomenon, Cu NCs / Met can be used as a fluorescent nanoprobe for the highly sensitive and selective detection of norfloxacin drug, and the detection process is simple and fast. The fluorescent nanoclusters prepared by this method have great application prospects in the fields of sensing, catalysis, photoelectric devices, anti-counterfeiting, cell imaging, and drug delivery.
Owner:HUAIBEI NORMAL UNIVERSITY
Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule
ActiveCN109970697BEconomical large-scale preparationGood for mass manufacturingOrganic chemistry methodsPropanoic acidPtru catalyst
The invention relates to a synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule. Using phenylpropionic acid as the starting material, react with monoethylmagnesium malonate to obtain β-ketoester, and then construct the spirolide structure through acid-catalyzed series Friedel-Crafts reaction in one pot, and then through trifluoroform The sulfonate ester activates the phenolic hydroxyl group, and finally removes the occupying atom and the sulfonate group by palladium-carbon hydrogenation to complete the synthesis of the chiral spiro[chroman-4,1'-dihydroindene] molecule. The racemate was optically resolved under the action of N-benzylhalogenated cinchonidine. The synthesis method overcomes the problems of poor atom economy, many synthetic wastes, and low practical value of the original method, and realizes simple and economical large-scale preparation of the target molecule; the separation method is green and efficient, and the separation reagent, solvent It can be used multiple times; the product molecule and synthesis method have important application value and potential in catalyst skeleton design and natural product drug synthesis.
![Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/26a7905c-7291-44c1-9928-222127a967de/DEST_PATH_IMAGE002.png "Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule")
![Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/26a7905c-7291-44c1-9928-222127a967de/BDA0002048279860000011.png "Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule")
![Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/26a7905c-7291-44c1-9928-222127a967de/BDA0002048279860000021.png "Synthesis method of chiral spiro[chroman-4,1'-dihydroindene] molecule")
Owner:NANKAI UNIV
Iron-based coordination compound with anti-tumor activity
InactiveCN106946949AThe synthesis method is simpleSynthetic method is economicalOrganic chemistry methodsIron group organic compounds without C-metal linkagesSpace groupPhenanthroline
The invention discloses an iron-based coordination compound with anti-tumor activity. The chemical formula of the iron-based coordination compound with anti-tumor activity is [Fe(C7H3NO4)(C12H8N2)*H2O]*2H2O; the molecular weight is 455.21; the iron-based coordination compound is of a zero-dimensional structure, and belongs to monoclinic system; space group is P2(1) / c; single cell parameters a=7.8226(16) angstroms, b=27.730(6) angstroms, c=9.2886(19) angstroms, alpha=gamma=90 DEG, beta=106.84(3) DEG, V=1928.5(7) angstrom<3>, and Z=4. The iron-based coordination compound is prepared taking 2,6-pyridinedicarboxylic acid, 1,10-phenanthroline, and FeCl<3>*6H<2>O solid as raw materials via normal-temperature solution volatilization method. The preparation method is simple; cost is low; the obtained iron-based coordination compound possesses excellent inhibition effect on chronic granulocytic leukemia cell strain K562 and esophageal carcinoma cell strain OE-19, and it is promising to prepare anti-tumor drugs from the iron-based coordination compound.
Owner:FUJIAN MEDICAL UNIV
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