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Europium-doped organic framework material, preparation method and applications thereof

An organic framework and molecular weight technology, applied in organic chemistry methods, luminescent materials, organic chemistry, etc., to achieve the effect of simple synthesis method and strong cancer cell inhibitory activity

Active Publication Date: 2020-05-01
FUJIAN MEDICAL UNIV
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Problems solved by technology

[0002] At present, rare earth metal-organic frameworks (Ln-MOFs) have attracted much attention due to their unique photoelectromagnetic, catalytic, thermal stability properties and topological structure, and have broad application prospects. They have made considerable achievements in the fields of chemistry, synthesis, and materials research. Huge progress, but still few applications in the fields of pharmacy, biology, and medicine

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  • Europium-doped organic framework material, preparation method and applications thereof
  • Europium-doped organic framework material, preparation method and applications thereof
  • Europium-doped organic framework material, preparation method and applications thereof

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Embodiment Construction

[0018] In order to make the content of the present invention easier to understand, the technical solutions of the present invention will be further described below in conjunction with specific embodiments, but the present invention is not limited thereto.

[0019] Dissolve HBTA (0.0298g, 0.1 mmol), 2,6-pydc (0.0334g, 0.2 mmol), NaOH (0.0240g, 0.6 mmol) in 10 mL of solvent (deionized water:methanol=7:3, v / v) In, after stirring at room temperature for 30 min, Eu(NO 3 ) 3 ·6H 2 O (0.0045g, 0.1mmol) solid, after mixing, place it in a polytetrafluoroethylene stainless steel reactor and continue to stir for 10min, then react at a constant temperature of 120°C for 3 days, then drop to room temperature at a rate of 10°C / h, and filter Rinse with distilled water to obtain C 14 h 11 N 3 o 8 White blocky crystals of Eu.

[0020] 1. Single crystal structure analysis

[0021] Under a stereomicroscope, select crystals of appropriate size, regular shape, and no obvious defects such as...

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Abstract

The invention discloses a europium-doped organic framework material, a preparation method and applications thereof, wherein the chemical formula of the organic framework material is C14H11N3O8Eu, andthe organic framework material is prepared by taking 1,4-bis(imidazole-1-yl)terephthalic acid, 2,6-pyridine dicarboxylic acid and Eu(NO3)3.6H2O as raw materials through a solvothermal method. The organic framework material prepared by the invention has obvious inhibiting effect on tumor cells, and has low toxicity to normal cells, so that the organic framework material is expected to be developedinto tumor treatment medicines.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a europium-doped organic framework material and a preparation method and application thereof. Background technique [0002] At present, rare earth metal-organic frameworks (Ln-MOFs) have attracted much attention due to their unique photoelectromagnetic, catalytic, thermal stability properties and topological structure, and have broad application prospects. They have made considerable achievements in the fields of chemistry, synthesis, and materials research. Huge progress, but the application in the fields of pharmacy, biology and medicine is still less. [0003] 1,4-bis(imidazol-1-yl)terephthalic acid ( , HBTA), is a newly synthesized nitrogen heterocyclic compound, which has certain fluorescence activity, has the advantages of nitrogen heterocyclic compounds and aromatic polycarboxylic acids, and has rich N and O coordination sites. Rare earth (Ln 3+ ) Metal io...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00C09K11/06A61P35/00C08G83/00
CPCC07F5/003C09K11/06A61P35/00C08G83/008C07B2200/13C09K2211/182C09K2211/1029C09K2211/1044Y02B20/00
Inventor 康杰孙伟明姚枫枫李祥辉张莉
Owner FUJIAN MEDICAL UNIV
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