The invention belongs to the technical field of medicine intermediate synthesis and discloses an erythromycin A oxime clean synthetic method and specially-combined reaction equipment for the same. The method includes: using polar solvent to dissolve erythromycin thiocyanate, inorganic acid salt of hydroxylamine and water-soluble alkali, adding dehydrating agent, controlling certain outlet pressure through the specially-combined reaction equipment, constantly boiling for dehydration, completely performing oximation of erythromycin A after a certain time, cooling to enable complete precipitation of oximate, filtering, alkalizing the oximate conventionally, continuing oximation synthesis of oximate mother liquor after a certain quantity of raw materials are supplemented, and cycling so to enable the erythromycin thiocyanate and auxiliary materials to be fully used to improve overall yield. The specially-combined reaction equipment mainly comprises a water bath 1, a reaction vessel 2, a dephlegmator 3, a separator 4, a condenser 5, a stirring motor 6, a buffering bottle 7, a vacuum meter 8, a regulating valve 9, a vacuum pump 10 and a thermometer 11.