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100 results about "Erythromycin thiocyanate" patented technology
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Preparation method of erythromycin thiocyanate
The invention relates to a preparation method of erythromycin thiocyanate, which comprises the following steps: adding sodium hydroxide into an erythromycin fermentation liquid to regulate the pH value, filtering, concentrating, and recrystallizing to obtain the erythromycin thiocyanate. The method provided by the invention greatly reduces the consumption of the organic solvent, lowers the production cost, reduces the generation of waste residues, and is beneficial to environmental protection and production safety.
Owner:YILI CHUANNING BIOTECH CO
Method for producing abomacetin rhodanate
InactiveCN101407533AReduce unit consumptionEasy biochemical treatmentSugar derivativesButyl acetateAbomacetin
The invention relates to a production method of erythromycin thiocyanate, which is characterized in that erythromycin filtrate is treated by bleaching subtraction resin and condensed to 18000u / ml-20000u / ml by a nanofiltration membrane with molecular weight of 600, strong ammonia water is introduced when the condensed liquid is condensed and heated to 55DEG C to 56 DEG C, the PH value is controlled from 9.8 to 10.0, the introducing time of ammonia is 30 minutes to 45 minutes, erythromycin alkali can be obtained by extracting and filtering a crystalline liquid immediately, and then the erythromycin alkali is dissolved to be a solution of 30000u / ml to 35000u / ml by butyl acetate, crystallization is carried out according to a method of solvent extraction crystallization, and then the thiocyanate erythromycin can be obtained by centrifugal separation. The production method of the erythromycin thiocyanate uses the method of water-phase crystallizing the erythromycin and then transferring salts by the solvent, the product quality is good, the unit consumption of the solvent is low, the yield is similar to the solvent method, moreover, the production wastewater realizes removing contamination and shunt, is easy to treat, and has good environmental benefit.
Owner:NINGXIA QIYUAN PHARMA
Comprehensive erythromycin thiocyanate mushroom dreg waste water disposal system and method
InactiveCN103332831AImprove efficiencyLarge amount of processingMultistage water/sewage treatmentFenton reactionTreatment effect
Owner:SHANDONG PACIFIC ENVIRONMENTAL PROTECTION
Method for detecting erythromycin series compounds and special-purpose enzyme-linked immunologic reagent kit thereof
InactiveCN101299046AHigh precisionSimple structureFused cellsMaterial analysisElisa kitErythromycin Ethylsuccinate
The present invention discloses a method for detecting the erythromycin compounds and an enzyme linked immunoreaction reagent kit thereof which is specialized for the method. The enzyme linked immunoreaction reagent kit comprises an erythromycin specific antibody, a coatingen and an enzyme label. The erythromycin specific antibody is a monoclone antibody or polyclonal antibody of the erythromycin. The erythromycin compound is at least one in erythromycin, erythromycin thiocyanate and erythromycin ethylsuccinate. The erythromycin is erythromycin A. The enzyme linked immunoreaction reagent kit of the invention has the advantages of simple structure, convenient use, low cost, convenient carriage, high efficiency of the detecting method, accuracy and easiness. The on-spot monitoring can be executed. Furthermore the enzyme linked immunoreaction reagent kit is suitable for the qualitative and quantitative sieving of considerable samples, and can exert an important function in the detection to the erythromycin.
Owner:贵州勤邦食品安全科学技术有限公司
Method for preparing erythromycin thiocyanate
The invention provides a method for preparing erythromycin thiocyanate, which uses a secondary crystallization method, the process is simple, no device is required, the quality of the erythromycin thiocyanate products can be partially increased, and the product quality fluctuation caused by change of quality of fermentation liquid can be overcome.
Owner:TOPFOND PHARMA CO LTD
Method for preparing erythromycin thiocyanate
ActiveCN102659881AEasy to operateLow costSugar derivativesSugar derivatives preparationAcetic acidButyl acetate
The invention provides a method for preparing erythromycin thiocyanate. The method comprises the following steps of: removing impurities from erythromycin fermentation liquor, and treating by using alkaline liquor; and extracting by using butyl acetate, collecting an organic phase, adding a sodium thiocyanate solution into the organic phase, controlling the pH value to be 4.0 to 6.0, stirring, crystallizing and drying to obtain erythromycin thiocyanate powder. According to the method, the erythromycin fermentation liquor is used as a raw material, and the refined erythromycin thiocyanate is obtained by impurity removal and a mode of combining extraction and the salifying of sodium thiocyanate. The method is easy to operate and low in cost, the requirement of mass production can be met, and a product is high in yield and purity.
Owner:ANHUI BBCA FERMENTATION TECH ENG RES
Preparation method of erythromycin thiocyanate
ActiveCN103113440AHigh purityHigh potencySugar derivativesSugar derivatives preparationHydrogenPurified water
The invention discloses a preparation method of erythromycin thiocyanate; the preparation method comprises the following steps of: (1) washing erythromycin thiocyanate crude product by 40-60 DEG C purified water, dissolving into 38-48 DEG C acetone, wherein the volume of acetone is 1-4 times of that of erythromycin thiocyanate crude product, adjusting pH (potential of hydrogen) to be 9.0-10.5, then washing by saturated NaCl, separating phases, throwing water phase away, so as to obtain acetone solution containing erythrocin alkali; and (2) adding thiocyanate into the erythrocin alkali acetone solution obtained in the step (1), acidifying, crystallizing, filtering, washing by purified water and drying, finally the erythromycin thiocyanate product is obtained. The erythromycin thiocyanate prepared by the method is excellent in quality, high in yield, low in production cost, and excellent in industrial application prospect.
Owner:SHANGHAI RECOM BIOTECHNOLOGY CO LTD
Composition for treating chicken mycoplasma respiratory infection and preparing method thereof
InactiveCN103417571AEasy dischargeEasy to removeAntibacterial agentsOrganic active ingredientsDiseaseRespiratory disease
The invention discloses a composition for treating chicken mycoplasma respiratory infection and a preparing method of the composition. The composition comprises, by weight, 1-10% of erythromycin thiocyanate, 40-90% of ammonium chloride and the balance anhydrous dextrose. According to the composition, the erythromycin thiocyanate is used as a main ingredient for resisting mycoplasmas, is effective in various mycoplasmas causing the chicken respiratory infection, is taken orally and can be absorbed, and can effectively treat mycoplasma infection of respiratory tracts; the ammonium chloride is an expectorant and enables sputum to be discharged easily through increase of sputum quantity, thereby facilitating removal of phlegm, enabling cheesy material and phlegm in tracheas to be diluted, dissolved and discharged out of the body, and keeping smooth breath. Through combination of the two medicines, the composition aims at pathogeny and also aims at symptomatic treatment, can effectively improve the cure rate, and reduces losses caused by respiratory disease characteristics.
Owner:TIANJIN SHENGJI GRP CO LTD
Method and device for extracting erythromycin thiocyanate
InactiveCN104262431AHigh purityHigh yieldSugar derivativesSugar derivatives preparationUltrafiltrationSolvent
The invention provides a method and device for extracting erythromycin thiocyanate. The method comprises the following steps: filtering erythromycin fermentation liquor by using an ultrafiltration membrane so as to remove impurities and colors, carrying out further impurities and colors removal on filter liquor by using the ultrafiltration membrane, concentrating filter liquor by using a nanofiltration membrane, and finally, carrying out extraction on the obtained product by using a recrystallization process, so that the high-purity erythromycin thiocyanate is obtained. Compared with traditional erythromycin thiocyanate extraction processes, the method and device disclosed by the invention have the advantages that the yield of extracted erythromycin A is high; the purity of the extracted erythromycin A is high; an operation process is simplified; and the solvent cost is reduced, the industrial pollution is less, and the like.
Owner:JIANGSU JIUWU HITECH
Erythromycin thiocyanate soluble powder and preparation method thereof
ActiveCN105147620AImprove solubilityStable in dark conditionsAntibacterial agentsPowder deliverySolubilitySodium citrate
The invention provides erythromycin thiocyanate soluble powder and relates to the field of veterinary medicine. The erythromycin thiocyanate soluble powder is prepared from, by mass, 1%-20% of erythromycin thiocyanate, 2%-40% of sodium citrate, 1%-20% of citric acid, 1%-5% of sodium dihydrogen phosphate, and the balance auxiliary materials. The invention further provides a method for preparing the erythromycin thiocyanate soluble powder. The prepared erythromycin thiocyanate soluble powder is good in solubility in water, the solubility of the erythromycin thiocyanate soluble powder in water reaches 5 g / L (counting as erythromycin), and the solubility of the erythromycin thiocyanate soluble powder in water is greatly increased. A water solution obtained after the erythromycin thiocyanate soluble powder is dissolved in water is very stable at the temperature of 25 DEG C and under the light shielding condition, and the degradation amount after 4 h is smaller than 5%.
Owner:BAODING JIZHONG PHARMA
Preparation method of erythromycin A(E) oxime
The invention discloses a preparation method for erythromycin A (E) oxime, which comprises the following steps: 1) in an organic solvent A, hydroxylamine hydrochloride reacts with an acid attaching agent with a molecular structural formula of M Y at the room temperature; then erythromycin thiocyanate is added for reaction; then crystallization, filtering and washing are carried out, and erythromycin A (E) oxime rhodanate is obtained; 2) in an organic solvent B, the erythromycin A (E) oxime rhodanate is added with alkali to have a neutralization reaction; then crystallization, filtering and washing are carried out, and the erythromycin A (E) oxime is obtained. The erythromycin A (E) oxime prepared by the method is characterized by good quality, little environmental pollution, etc.
Owner:ZHEJIANG GUOBANG PHARMA
Treatment process and device of wastewater produced by erythromycin thiocyanate
ActiveCN103319053AReduce energy consumptionLess investmentMultistage water/sewage treatmentNature of treatment waterSludgeDecomposition
The invention relates to a treatment process and device of wastewater produced by erythromycin thiocyanate. The treatment process comprises the following steps of: evaporating high-concentrate wastewater produced by erythromycin thiocyanate by an evaporator in cycle, mixing evaporated low-concentrate water with low-concentrate wastewater produced by the erythromycin thiocyanate, then carrying out hydrolytic acidification, adjusting the pH value, carrying out anaerobic microbial decomposition, precipitating the decomposed wastewater after treatment by active sludge, carrying out ozone oxidization treatment on a clear liquid, and precipitating and discharging after treatment by the active sludge. The wastewater disclosed by the invention adopts the biological treatment process of combining 'four-effect evaporator, hydrolytic acidification, two-stage contact oxidation process and advanced treatment (ozone-Fenton reaction)'. Thus, the treatment device is low in energy consumption, small in investment, high in efficiency, and stable and reliable in treatment effect.
Owner:SHANDONG PACIFIC ENVIRONMENTAL PROTECTION
Method for refining and preparing erythromycin thiocyanate
ActiveCN103275150ALow costLow puritySugar derivativesSugar derivatives preparationButyl acetateEthyl acetate
Owner:SHANGHAI RECOM BIOTECHNOLOGY CO LTD
Method for preparing erythromycin thiocyanate gelatin microsphere preparation
InactiveCN102525946AImprove bioavailabilityReduce dosageAntibacterial agentsOrganic active ingredientsCapillary networkMicrosphere
Owner:QINGDAO AGRI UNIV
Medicine composite containing erythromycin thiocyanate and preparation method thereof
ActiveCN105125570AImprove solubilityImprove infection abilityAntibacterial agentsOrganic active ingredientsSolubilityMedicine
The invention relates to a medicine composite containing erythromycin thiocyanate and a preparation method thereof. The composite comprises erythromycin thiocyanate, stabilizers, solubilizer and auxiliary materials. The preparation method includes the steps that the stabilizers, the solubilizer and erythromycin thiocyanate are evenly mixed, and the mixture is screened by a screen of 80-120 meshes in a smashed mode to obtain a semi-finished product; the auxiliary materials are screened by a screen of 80-100 meshes in a smashed mode to be thrown into a mixing tank; then the semi-finished product is added, even mixing is performed, and the medicine composite is obtained through sub-packaging. The approximate solubility of the medicine composite containing erythromycin thiocyanate in water is remarkably improved, stability is good, and through six months of acceleration tests, all detection items meet quality standards. The water solution of the medicine composite is not likely to be affected by temperature, water quality hardness and other objective factors, the content of effective components in drinking water can be kept unchanged for 24 hours, exertion of the medicine effect is guaranteed, and the effect of resisting gram-positive bacteria and mycoplasma infection is remarkably improved for livestock.
Owner:QINGDAO KDN BIOTECH +1
Refinement method of erythromycin thiocyanate
ActiveCN105601687AEfficient removalHigh light transmittanceSugar derivativesSugar derivatives preparationAlcoholSodium thiocyanate
The invention provides a refinement method of thiocyanate erythromycin. The method comprises the following steps: a. taking an erythromycin thiocyanate crude product, adding a solvent and a mixed alkali solution for dissolution, and removing insoluble substances to obtain a supernatant, wherein the mixed alkali solution is a water solution comprising sodium hydroxide and sodium carbonate, the mole ratio of the sodium hydroxide to the sodium carbonate in the mixed alkali solution is 9:1-1:9, and the solvent is an alcohol solvent or acetone; and b. adding sodium thiocyanate into the supernatant in the step a, regulating the pH value to 6.0-9.0, crystallizing, filtering, and drying to obtain the erythromycin thiocyanate finished product. The erythromycin thiocyanate finished product prepared by the method has the advantages of high light transmittance, high yield and high product quality, and has favorable industrial application prospects.
Owner:四川新迪生物制药有限公司
Preparation method of erythromycin thiocyanate
ActiveCN110003295AReduce solubilityReduce the ratioSugar derivativesSugar derivatives preparationAcetic acidPhase splitting
The invention relates to the technical field of crystallization engineering, in particular to a preparation method of erythromycin thiocyanate. The method comprises the following steps that a solventis added into crude erythromycin thiocyanate, a sodium hydroxide solution is used for regulating the pH value, and a mixed solution is obtained; sodium chloride solids are added into the mixed solution, standing is performed after stirring is performed, and phase splitting is performed to a supernate I; then, a saturated sodium chloride solution continues to be added into the supernate I, standingis performed after stirring is performed, phase splitting is performed, and a supernate II is obtained; a sodium thiocyanate solution is added into the supernate II, then, glacial acetic acid is added to regulate pH, reduced pressure distillation is performed, cooling is performed to reach 15-30 DEG C, and centrifuging is performed to obtain a wet erythromycin thiocyanate product; the wet erythromycin thiocyanate product is smashed and dried to obtain erythromycin thiocyanate. The preparation method of the erythromycin thiocyanate has the advantages that the technology is simple, control is easy, little wastewater is produced, the yield of the prepared erythromycin thiocyanate is high, and the purity of the prepared erythromycin thiocyanate is high.
Owner:HEC PHARM CO LTD
Refining method of erythromycin thiocyanate
ActiveCN103275151AReduce material consumptionReduce manufacturing costSugar derivativesSugar derivatives preparationSolventImpurity
The invention provides a refining method of erythromycin thiocyanate. The refining method of the erythromycin thiocyanate mainly comprises the following steps of: (1), preliminarily discoloring erythrocin filtrate by a flocculating agent to remove impurities, extracting the purified solution by a special-purpose erythromycin solvent, and further discoloring the extracting solution by active carbon to remove impurities; and (2), inverting the treated erythrocin extracting solution to a purifying water phase by phase inversion, extracting the thiocyanate in the water phase to a solvent mixture of n-butyl acetate and cyclohexane, thereby obtaining an erythrocin crystallization solution by utilizing a two-step crystallization method, and separating and drying to obtain an erythromycin thiocyanate finished product. The content of erythrocin A in the finished product is more than 83%. In order to solve the defect that the content of erythrocin A in the erythromycin thiocyanate finished product, which is prepared by extracting the erythrocin from erythrocin filtrate by utilizing special-purpose solvent, crystallizing the extracting solvent and finally separating and drying in a conventional production process, is low, the refining method of the erythromycin thiocyanate can be used for improving the content of the erythrocin A in the erythromycin thiocyanate finished product by discoloring the filtrate and the extracting solution to remove impurities and adopting a two-step crystallizing process after phase inversion.
Owner:NINGXIA QIYUAN PHARMA
Refining method and preparation method of erythromycin thiocyanate
InactiveCN102911228ALow costLow puritySugar derivativesSugar derivatives preparationEthyl acetateSolid matter
The invention provides a refining method of erythromycin thiocyanate and a preparation method of the erythromycin thiocyanate. The refining method of the erythromycin thiocyanate comprises the following steps of: (1) dissolving an erythromycin thiocyanate coarse product in a solvent, performing alkaline treatment, filtering off insoluble matters, adding thiocyanate and then adding acid to regulate pH (Potential of Hydrogen) to be 5.5-8.3; and (2) separating a solid matter out, washing and drying to obtain an erythromycin thiocyanate finished product, wherein the solvent in the step (1) is methanol, ethanol or isopropyl alcohol; or the solvent is mixed solvent of more than two of methanol, ethanol, isopropyl alcohol, water, acetone, dichloroethane, ethyl acetate and butyl acetate; and the content of the methanol, the ethanol or the isopropyl alcohol is over 30 percent w / w in the mixed solvent. According to the refining method and the preparation method of the erythromycin thiocyanate, the technical bias that the erythromycin impurity cannot be reduced because of mixing of the solvent and the water existing in the conventional method is overcome, the purity and the yield of the erythromycin thiocyanate finished product are not reduced, the solvent cost is also obviously saved, and the technological steps are also obviously simplified.
Owner:YILI CHUANNING BIOTECH CO
Compound preparation for preventing and treating respiratory diseases of beasts and birds
InactiveCN103784700AGood treatment effectEffective controlPowder deliveryClimate change adaptationFuranTreatment effect
The invention discloses a compound preparation for preventing and treating respiratory diseases of beasts and birds. The compound preparation comprises, by weight, auxiliary materials 1-2 parts, traditional Chinese medicine preparation 30-50 parts and chemical synergist 10-20 parts. The auxiliary materials include isovaleraldehyde 5-10 parts, 2-pentyl-furan 5-10 parts, vanillin 5-10 parts and xanthan gum 2-5 parts. The chemical synergist comprises aminoglycosides 5-10 parts, florfenicol 5-10 parts, amoxicillin 5-10 parts, erythromycin thiocyanate 5-10 parts and ferrous fumarate 2-4 parts. Substance having various physiological activities in a traditional Chinese medicine formula having synergistic effect is extracted and compatible with the chemical synergist through Chinese herbal compound preparation, so that the compounded medicine has good treatment effect on the respiratory diseases and can effectively prevent and treat the diseases. In addition, main medicine is a traditional Chinese medicine extract and can effectively prevent drug resistance, and the medication safety is also improved.
Owner:SICHUAN TIANHONG ANIMAL HUSBANDRY
Preparation method of erythromycin 6,9 imino ether
ActiveCN103319551AIncrease profitSugar derivativesSugar derivatives preparationHydroxylamineErythromycin Oxime
The invention discloses a preparation method of erythromycin 6,9 imino ether. The method comprises the following steps: 1) with lower alcohols as reaction solvents, erythromycin thiocyanate reacts with hydroxylamine to generate thiocyanate salts of erythromycin; 2) water and water-immiscible low-polar organic solvents are added dropwise into the reaction mixture when the content of erythromycin detected with HPLC is less than 0.5%, lye is added into the mixture, after the mixture is fully mixed, to achieve a pH between 9 and 12, the mixture is allowed to stand to stratify, and a water layer is removed; 3) mesyl chloride or toluene sulfochloride is added into an organic layer for reactions of the Beckman arrangement to generate erythromycin 6,9 imino ether. The method provided by the invention simplifies operations by removing extraction of erythromycin oxime and salts of erythromycin oxime, and thus the conversion rate of erythromycin is improved and the cost of production equipment and energy is reduced. By means of the technology provided by the invention, the weight yield and the HPLC purity of erythromycin 6,9 imino ether synthesized by erythromycin thiocyanate can achieve more than 72% and more than 92% respectively.
Owner:TOPFOND PHARMA CO LTD
Method for directly preparing erythromycin oxime by utilizing erythromycin fermentation liquid
InactiveCN107987113AReduce usageInhibit productionSugar derivativesSugar derivatives preparationOrganic solventErythromycin Oxime
The invention relates to a method for directly preparing erythromycin oxime by utilizing erythromycin fermentation liquid. The method comprises the following steps: filtering the erythromycin fermentation liquid by a membrane filtering method, extracting by an organic solvent, performing dehydration and decoloring treatment, freezing and crystallizing to prepare erythromycin crude alkali, performing oximation reaction to prepare oximate, extracting the oximate by using an organic solvent, performing dehydration and decoloring treatment, freezing for crystallization, and filtering and drying toobtain the erythromycin oxime. By the method, the advantage of the enterprise for producing the erythromycin raw material is completely exerted, the technological process of thiocyanic acid and erythromycin salifying crystallization is eliminated, and the intermediate erythromycin crude alkali for preparing the erythromycin thiocyanate directly serves as a starting raw material for synthesizing erythromycin A9-oxime, so that the process is simplified, the process flow is shortened, the production cost is reduced, environmental pollution is little, the product yield is high and the product quality is high.
Owner:NINGXIA QIYUAN PHARMA
A kind of preparation method of erythromycin thiocyanate
Disclosed is a preparation process of erythromycin thiocyanate, which belongs to the pharmaceutical field. The preparation process provided by the invention uses erythromycin or its salt(s) as raw material(s), dissolves it / them in acetone or the mixed solvent containing acetone and obtains erythromycin thiocyanate rich in erythromycin thiocyanate A as the main component and low in the content of impurities. Said erythromycin thiocyanate could be used as the raw material for preparing Azithromycin and Clarithromycin, which meets to the standards made by European Union and US.
Owner:HEC PHARM CO LTD
Virus medicine for silk worm
The compound viral disease preventing and treating medicine preparation for silk worm consists of erythromycin thiocyanate as main medicine component and chlorine dioxide powder as auxiliary medicine component in the weight ratio of 1 to 3-10, preferably 1 to 4-6 and packed separately. When the medicine preparation is used, chlorine dioxide powder is first dissolved, erythromycin thiocyanate is then added for mixing homogeneously, water in 500 times is added and the medicine liquid is sprayed to mulberry leaf fed to silk worm to prevent and treat viral disease.
Owner:陈怀亮
Erythromycin thiocyanate soluble powder and preparation method thereof
InactiveCN108324689AExpand the scope of antibacterialImprove product qualityAntibacterial agentsPowder deliveryBiotechnologyOrganic solvent
The invention discloses erythromycin thiocyanate soluble powder and a preparation method thereof. The erythromycin thiocyanate soluble powder is characterized in that each 1000g of the erythromycin thiocyanate soluble powder is prepared from 50 to 200g of erythromycin thiocyanate, 30 to 100g of beta-cyclodextrin, 5 to 20g of corrective, 10 to 30g of acid and alkali regulator, 5 to 50g of slow-release high molecular material, 50 to 200ml of organic solvent, 40 to 500ml of purified water and the balance of water-soluble starch. The erythromycin thiocyanate soluble powder disclosed by the invention has the advantages that (1) a product can be industrially produced in a large batch and the cost is relatively low; the batch is relatively large so that various loss in a production process is reduced and the rate of finished products is effectively improved. Meanwhile, the batch is large so that other cost in a production process is reduced to the greatest extent; (2) the corrective and the slow-release molecular material are introduced into the product and are mutually matched so that the problem that the mouthfeel is not good and the half-life period is short is solved and an antibacterial range of a medicine is enhanced. The medicinal effect of the product can reach or exceed that of a similar product erythromycin thiocyanate soluble powder.
Owner:JIANGXI AGRICULTURAL UNIVERSITY
Veterinary-use soluble powder and preparation method and application method thereof
InactiveCN105997885ASolve and guarantee solubilityImprove efficiencyAntibacterial agentsOrganic active ingredientsNeomycin SulfatePotato starch
The invention belongs to the field of veterinary medicine and discloses veterinary-use soluble powder and preparation method and application method thereof. The veterinary-use soluble powder is prepared by using optional one of neomycin sulfate, apramycin sulfate and erythromycin thiocyanate as the active component, using filling agent and solubilizing assistant as the auxiliary materials and adding purple sweet potato starch. The preparation method includes: performing superfine crushing on the active component, and sieving with a No.9 sieve; respectively weighing the processed active component, the filling agent, the solubilizing assistant and the purple sweet potato starch according to formula weight, and evenly mixing with an equal-increasing mixing method. The application method includes: adding the soluble powder into water, and adding alkali substances into the solution if the solution is red until the solution suddenly changes from red to blue; adding alkali substances into the solution if the solution is purple until the solution is gradually changed into yellowish brown. By the veterinary-use soluble powder, the optimal effect of antibacterial drugs can be achieved, abuse of the antibacterial drugs can be avoided, and cost is saved.
Owner:合肥中龙神力动物药业有限公司
Compound erythromycin thiocyanate soluble powder for livestock and preparation method therefor
InactiveCN106389454AHas strong liver and choleretic effectAnti-inflammatoryAntibacterial agentsPowder deliveryIrritationTaurine
The invention discloses compound erythromycin thiocyanate soluble powder for livestock. The compound erythromycin thiocyanate soluble powder for livestock is prepared from the following components in a mixing manner: erythromycin thiocyanate, taurine and the balance of auxiliary materials. The compound erythromycin thiocyanate soluble powder for livestock also can reinforce metabolism of liver on erythromycin thiocyanate and can relieve gastrointestinal discomfort symptoms, may caused by erythromycin thiocyanate irritation, of livestock.
Owner:RINGPU TIANJIN BIOLOGICAL PHARMA
Erythromycin A oxime clean synthetic method and specially-combined reaction equipment for same
InactiveCN102911225APromote conversionLow costSugar derivativesSugar derivatives preparationWater bathsHydroxylamine
The invention belongs to the technical field of medicine intermediate synthesis and discloses an erythromycin A oxime clean synthetic method and specially-combined reaction equipment for the same. The method includes: using polar solvent to dissolve erythromycin thiocyanate, inorganic acid salt of hydroxylamine and water-soluble alkali, adding dehydrating agent, controlling certain outlet pressure through the specially-combined reaction equipment, constantly boiling for dehydration, completely performing oximation of erythromycin A after a certain time, cooling to enable complete precipitation of oximate, filtering, alkalizing the oximate conventionally, continuing oximation synthesis of oximate mother liquor after a certain quantity of raw materials are supplemented, and cycling so to enable the erythromycin thiocyanate and auxiliary materials to be fully used to improve overall yield. The specially-combined reaction equipment mainly comprises a water bath 1, a reaction vessel 2, a dephlegmator 3, a separator 4, a condenser 5, a stirring motor 6, a buffering bottle 7, a vacuum meter 8, a regulating valve 9, a vacuum pump 10 and a thermometer 11.
Owner:SHANDONG FANGMING PHARMACEUTICAL CO LTD
Preparation process of erythromycin thiocyanate
Disclosed is a preparation process of erythromycin thiocyanate, which belongs to the pharmaceutical field. The preparation process provided by the invention uses erythromycin or its salt(s) as raw material(s), dissolves it / them in acetone or the mixed solvent containing acetone and obtains erythromycin thiocyanate rich in erythromycin thiocyanate A as the main component and low in the content of impurities. Said erythromycin thiocyanate could be used as the raw material for preparing Azithromycin and Clarithromycin, which meets to the standards made by European Union and US.
Owner:HEC PHARMA CO LTD
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