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Preparation method of erythromycin thiocyanate

A technology of erythromycin thiocyanate and erythromycin, which is applied in the field of medicine and biology, can solve the problems of unfavorable environmental protection and operation safety, large demand for organic solvents, large solvent consumption, etc., and achieve environmental protection and production safety , Reduce the generation of waste residue and reduce the use of organic solvents

Active Publication Date: 2012-04-11
YILI CHUANNING BIOTECH CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage of this process is: the solvent consumption is large during butyl acetate extraction
This method has complex operation, and direct extraction with fermentation filtrate requires a large amount of organic solvent, which is not conducive to environmental protection and operational safety.

Method used

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  • Preparation method of erythromycin thiocyanate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of erythromycin fermented liquid

[0048] (1) Concentration of fermented liquid: After removing slag from erythromycin fermented liquid, adjust the pH to 8.0-8.4 with a 10% sodium hydroxide solution, filter through a ceramic membrane with a pore size of 50nm-100nm, and filter the filtrate with 200 molecular weight nano Concentrate through the filter membrane to obtain a concentrated solution of erythromycin.

[0049] (2) Recrystallization: place the erythromycin concentrate in a crystallization tank, add 10% sodium thiocyanate solution (add 0.18kg of 10% sodium thiocyanate solution per billion units of erythromycin), use 50% The glacial acetic acid solution adjusts the pH to be 6.0~6.5, crystallizes out erythromycin thiocyanate, and the solid-liquid mixture is centrifuged to obtain the crude product of erythromycin thiocyanate, and the crude product of erythromycin thiocyanate is added into acetone according to the ratio of 1:4, Use a 10% ...

Embodiment 2

[0055] Embodiment 2: a kind of preparation method of erythromycin thiocyanate

[0056] (1) Concentration of fermented liquid: After removing slag from erythromycin fermented liquid, adjust the pH to 7.8-8.2 with a 15% sodium hydroxide solution, filter through a ceramic membrane with a pore size of 50nm-100nm, and filter the filtrate with a 200-molecular-weight nanometer Concentrate through the filter membrane to obtain a concentrated solution of erythromycin.

[0057] (2) Recrystallization: place the erythromycin concentrate in a crystallization tank, add 15% sodium thiocyanate solution (add 0.15kg of 15% sodium thiocyanate solution per billion units of erythromycin), use 40% The glacial acetic acid solution adjusts the pH to be 6.0~6.5, crystallizes out erythromycin thiocyanate, and the solid-liquid mixture is centrifuged to obtain the crude product of erythromycin thiocyanate, and the crude product of erythromycin thiocyanate is added into acetone according to the ratio of 1...

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Abstract

The invention relates to a preparation method of erythromycin thiocyanate, which comprises the following steps: adding sodium hydroxide into an erythromycin fermentation liquid to regulate the pH value, filtering, concentrating, and recrystallizing to obtain the erythromycin thiocyanate. The method provided by the invention greatly reduces the consumption of the organic solvent, lowers the production cost, reduces the generation of waste residues, and is beneficial to environmental protection and production safety.

Description

technical field [0001] The invention relates to a preparation method of erythromycin thiocyanate, in particular to a primary aqueous phase crystallization and acetone recrystallization process of erythromycin thiocyanate, which belongs to the field of medical biotechnology. Background technique [0002] Erythromycin is an alkaline antibiotic isolated from the culture medium of Streptomyces rubrum in 1952. Erythromycin has a broad-spectrum antibacterial effect on Gram-positive bacteria, such as Staphylococcus, Streptococcus pyogenes, Streptococcus viridans, Streptococcus pneumoniae, Streptococcus faecalis, Clostridium difficile, and Bacillus diphtheria have strong inhibitory effects. It also has considerable inhibitory effect on Gram-negative bacteria, such as Neisseria gonorrhoeae, Helicobacter, Pertussis, Brucella, Legionella, Haemophilus influenzae, and Bacteroides. my country has successfully trial-produced it since 1957 and gradually put it into mass production. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06C12P19/62C12R1/465
CPCY02P20/10Y02P20/59
Inventor 邹太平王利春刘思川梁隆程志鹏邓芸黄海玉
Owner YILI CHUANNING BIOTECH CO
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