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Method for preparing erythromycin thiocyanate gelatin microsphere preparation

A technology of erythromycin thiocyanate and gelatin, applied in the agricultural field, can solve the problems of slow degradation rate of PLGA, expensive albumin, inability to remove, etc., and achieves the effects of improving bioavailability, simple preparation method and reducing drug dosage.

Inactive Publication Date: 2012-07-04
QINGDAO AGRI UNIV
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  • Description
  • Claims
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Problems solved by technology

However, in the research of lung-targeting microspheres at home and abroad, there are still some problems in the selection of carrier materials and the preparation of microspheres: for example, albumin is expensive and requires high storage conditions, which is not suitable for

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  • Method for preparing erythromycin thiocyanate gelatin microsphere preparation
  • Method for preparing erythromycin thiocyanate gelatin microsphere preparation
  • Method for preparing erythromycin thiocyanate gelatin microsphere preparation

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Abstract

The invention discloses a method for preparing an erythromycin thiocyanate gelatin microsphere preparation. The method comprises the following steps of: forming water-in-oil (W/O) emulsion with mechanical stirring by using gelatin as a carrier, using liquid paraffin as an oil phase and using Span85 and Tween80 as a mixed emulsifier, cooling glutaraldehyde at a low temperature, performing cross linking and curing, and thus obtaining microspheres of 7 to 20 microns. In intravenous administration, after the microsphere suspension is injected through the vein, the microsphere suspension is in contact with a lung capillary network of which diameter is 3 to 11 microns and is effectively intercepted by the lung; and medicaments in the microspheres are slowly released, so that a stable and long-term effective concentration is obtained. The preparation is prepared by adopting an emulsification and condensation polymerization method; and the method is low in equipment requirements, low in preparation cost and easy to popularize and apply.

Description

technical field [0001] The invention belongs to the technical field of agriculture and relates to a preparation method of erythromycin thiocyanate gelatin microsphere preparation. Background technique [0002] Sustained-release and controlled-release preparations are also called sustained-release and controlled-release drug delivery systems. They do not require frequent administration and can effectively reduce the amount of drug administered to sick animals. In addition, slow-release and controlled-release drugs can reduce the blood drug concentration. Fluctuation, so that it maintains a stable blood concentration in the human body, greatly improving the efficacy and reducing side effects. However, in the research of lung-targeting microspheres at home and abroad, there are still some problems in the selection of carrier materials and the preparation of microspheres: for example, albumin is expensive and requires high storage conditions, which is not suitable for the resear...

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Application Information

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IPC IPC(8): A61K9/16A61K31/7048A61K47/42A61P11/00A61P31/04
Inventor 刘焕奇钱泽升邹明张启迪毕可东曲志娜
Owner QINGDAO AGRI UNIV
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