Erythromycin thiocyanate soluble powder and preparation method thereof
A technology of erythromycin thiocyanate and erythromycin thiocyanate containing erythromycin thiocyanate, which is applied in the field of erythromycin thiocyanate soluble powder and its preparation, can solve the problems of poor taste and short half-life, and achieve low cost and batch Great effect of reducing other costs
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Embodiment 1
[0021] (1) First mix erythromycin thiocyanate 50g, β-cyclodextrin 30g, neotame 5g, sodium saccharin 10g, citric acid 10g, sodium citrate 25g, hydroxypropyl methylcellulose 25g, polyvinylpyrrolidone K30 10g and 835g of water-soluble starch were weighed separately and placed in different containers. spare.
[0022] (2) Take 50ml of polyethylene glycol and 150ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, add the pre-dissolved content in purified water Use 20% sodium citrate solution to bring the pH to 4.0-5.0.
[0023] (3) Take 300ml of purified water and heat it to 80°C, add sodium saccharin, neotame, citric acid, hydroxypropyl methylcellulose, polyvinylpyrrolidone k30, and water-soluble starch weighed in step 1, stir well and dissolve.
[0024] (4) Mix the solutions in step 2 and step 3 evenly, and continue stirring at a stirring speed of 300r / min for 30 minutes. The measured pH valu...
Embodiment 2
[0027] (1) First mix erythromycin thiocyanate 150g, β-cyclodextrin 50g, aspartame 15g, citric acid 15g, sodium bicarbonate 30g, sodium dihydrogen phosphate 10g, hydroxypropyl methylcellulose 25g, 15g of sodium carboxymethylcellulose and 690g of water-soluble starch were weighed respectively and placed in different containers. spare.
[0028] (2) Take 100ml of polypropylene glycol and 150ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, add purified water to pre-dissolve the content to 20% Sodium bicarbonate solution and 20% sodium dihydrogen phosphate solution make the pH reach 4.0-5.0.
[0029] (3) Take 500ml of purified water and heat it to 80°C, add aspartame, citric acid, sodium carboxymethylcellulose, hydroxypropylmethylcellulose, and water-soluble starch weighed in step 1, stir well and dissolve.
[0030] (4) Mix the solutions in step 2 and step 3 evenly, and continue stirring at ...
Embodiment 3
[0033] (1) First add erythromycin thiocyanate 200g, β-cyclodextrin 100g, aspartame 15g, sodium saccharin 5g, citric acid 30g, sodium citrate 30g, sodium dihydrogen phosphate 5g, hydroxypropyl methyl Weigh 25g of cellulose, 50g of polyvinylpyrrolidone k30, 5g of sodium carboxymethylcellulose, and 530g of water-soluble starch, and place them in different containers for later use.
[0034] (2) Take 200ml of polypropylene glycol and 100ml of ethanol and heat to 60°C, add β-cyclodextrin and erythromycin thiocyanate that have been weighed in step 1, stir and dissolve evenly, and add 20% pre-dissolved with purified water Sodium citrate solution and 20% sodium dihydrogen phosphate solution make the pH reach 4.0-5.0.
[0035] (3) Take 500ml of purified water and heat it to 80°C, add aspartame, sodium saccharin, citric acid, sodium carboxymethylcellulose, polyvinylpyrrolidone k30, and hydroxypropylmethylcellulose weighed in step 1 , Stir the water-soluble starch evenly and dissolve it....
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