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A kind of erythromycin thiocyanate emulsion and preparation method thereof

A technology of erythromycin thiocyanate and emulsion, which is applied in the direction of pharmaceutical formula, emulsion delivery, medical preparations containing active ingredients, etc., and can solve problems such as increasing the frequency of administration, increasing the amount of injection, and unfavorable disease treatment. Achieve the effect of stable properties and convenient use

Active Publication Date: 2016-06-08
天津中益达生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Erythromycin thiocyanate is white or off-white crystal when it is solid. If it is taken orally in the treatment of livestock and poultry, there will be a problem with the absorption rate. When using it, medical personnel often use injections, but erythromycin thiocyanate can It is very slightly soluble, so it is necessary to increase the injection volume and increase the frequency of administration during clinical injection, which will inevitably increase the physiological burden on livestock and poultry, which is not conducive to the treatment of diseases

Method used

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  • A kind of erythromycin thiocyanate emulsion and preparation method thereof
  • A kind of erythromycin thiocyanate emulsion and preparation method thereof
  • A kind of erythromycin thiocyanate emulsion and preparation method thereof

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preparation example Construction

[0031] The preparation method of above-mentioned erythromycin thiocyanate emulsion comprises the following steps:

[0032] (1) Take the co-solvent and heat it to 80 degrees Celsius to turn it into a transparent water-like liquid;

[0033] (2) Take erythromycin thiocyanate and dispersant, put them into purified water, heat to 45-65 degrees Celsius, and keep stirring, so that the solution turns into a milky white uniform liquid;

[0034] (3) mixing the products of step (1) and step (2) to form a milky white uniform liquid;

[0035] (4) adding a thickener to the product of step (3), making the liquid change into milky white viscous liquid;

[0036] (5) The product of step (4) is added with purified water to make the volume to 100 milliliters to obtain the finished product.

Embodiment 1

[0038] Preparation of an emulsion with a concentration of 1% erythromycin thiocyanate

[0039] (1) Take 10 ml of glycerin and heat it to 80 degrees Celsius to turn it into a transparent water-like liquid;

[0040] (2) Take 1 g of erythromycin thiocyanate and 0.2 g of polyethylene glycol, put them into 50 ml of purified water, heat to 45-65 degrees Celsius, and keep stirring to turn the solution into a milky white uniform liquid;

[0041] (3) mixing the products of step (1) and step (2) to form a milky white uniform liquid;

[0042] (4) Add 0.5 gram of carrageenan to the product of step (3), and make the liquid change into milky white viscous liquid;

[0043] (5) The product of step (4) is added with purified water to make the volume to 100 milliliters to obtain the finished product.

Embodiment 2

[0045] Preparation of an emulsion with a concentration of erythromycin thiocyanate of 5%

[0046] (1) Take 15 ml of propylene glycol and heat it to 80 degrees Celsius to turn it into a transparent water-like liquid;

[0047] (2) Take 5 grams of erythromycin thiocyanate and 1 gram of polyvinylpyrrolidone, put them into 50 ml of purified water, heat to 65 degrees Celsius, and keep stirring, so that the solution turns into a milky white uniform liquid;

[0048] (3) mixing the products of step (1) and step (2) to form a milky white uniform liquid;

[0049] (4) add 1 gram of carrageenan to the product of step (3), and make the liquid change into milky white viscous liquid;

[0050] (5) The product of step (4) is added with purified water to make the volume to 100 milliliters to obtain the finished product.

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Abstract

The present invention relates to an erythromycin thiocyanate emulsion, wherein erythromycin thiocyanate is weighed, is mixed with a dispersing agent in water, is blended with an auxiliary solvent, is subjected to thickening through a carrageenan, and then is subjected to volume metering to prepare the finished product. According to the present invention, with detection, the emulsions with different contents can be completely and uniformly mixed with water, the solubility of the emulsion is far higher than the monomer erythromycin thiocyanate, the character is stable and no precipitation is generated after long-term storage, and the agents with a plurality of concentrations can be prepared according to requirements of different diseases, such that the use is convenient.

Description

technical field [0001] The invention belongs to the technical field of erythromycin thiocyanate stable preparations, in particular to an erythromycin thiocyanate emulsion and a preparation method thereof. Background technique [0002] Erythromycin thiocyanate, also known as colomycin and erythromycin thiocyanate, belongs to macrolide antibiotics and is the thiocyanate of erythromycin. Staphylococcus aureus, Streptococcus, and Pneumococcus in bacteria have strong effects, and they also have certain effects on Pasteurella and Brucella in Gram-negative bacteria. , Actinomycetes, Nocardia, etc. are effective, such as: livestock and poultry pneumonia, sepsis, endometritis, mastitis, chronic respiratory diseases of livestock and poultry, grass carp and bighead carp and other fish infectious diseases. [0003] Erythromycin thiocyanate is white or off-white crystal when it is solid. If it is taken orally in the treatment of livestock and poultry, there will be a problem with the ab...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/7048A61P31/04
Inventor 刘鼎阔陶荣王立红赵云英赵晶晶张俊霞
Owner 天津中益达生物技术有限公司
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