The invention relates to the field of veterinary drug residue detection, in particular to an analysis method for efficiently detecting multiple residues of chloramphenicol, thiamphenicol, florfenicoland metabolite florfenicol amine of the florfenicol in eggs. An ultra-high performance liquid chromatography-tandem mass spectrum detection method for the multiple residues of the chloramphenicol, thethiamphenicol, the florfenicol and the metabolite florfenicol amine of the florfenicol in eggs is established for the first time; the appearance time of target compounds is short (1 min about), the sensitivity is high (the LOD of CAP, the LOD of TAP, the LOD of FF and the LOD of FFA are 0.03 microgram / kg, 0.3 microgram / kg, 0.1 microgram / kg and 0.4 microgram / kg in eggs respectively, and the LOQ ofthe CAP, the LOQ of the TAP, the LOQ of the FF and the LOQ of the FFA are 0.08 microgram / kg, 0.8 microgram / kg, 0.27 microgram / kg and 1.2 micrograms / kg in eggs respectively), the recovery rates when the adding concentrations of the CAP, the TAP, the FF and the FFA are LOQ, 0.5 MRL, 1.0 MRL and 2.0 MRL in eggs respectively are larger than or equal to 90.31%, 93.40%, 92.32% and 92.35% respectively,and the within-day relative standard deviation and the daytime relative standard deviation are lower than 4.33% and 5.77 % respectively. Meanwhile, the analysis method is simple in elution program, small in solvent consumption, higher in analysis efficiency, short in time consumption (each sample needs 4 min) and more suitable for application and popularization in mass sample analysis.