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Rapid classification and identification of chemical components in Kudiezi injection based on uplc-q-tof-ms technology

A UPLC-Q-TOF-MS, rapid classification technology, applied in scientific instruments, material separation, analysis of materials, etc., can solve problems such as analysis, classification and identification difficulties, and achieve moderate retention time and short peak time

Active Publication Date: 2016-10-05
TONGHUA HUAXIA PHARMA
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Problems solved by technology

By establishing a diagnostic debris filtering strategy and a neutral loss filtering strategy, and using them for the rapid screening of the attributable component groups in the fingerprint of Kudiezi injection, the technical problems of analysis, classification and identification difficulties caused by complex components of traditional Chinese medicine injections are effectively solved.

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  • Rapid classification and identification of chemical components in Kudiezi injection based on uplc-q-tof-ms technology
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  • Rapid classification and identification of chemical components in Kudiezi injection based on uplc-q-tof-ms technology

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Embodiment Construction

[0022] Rapid classification and identification of ingredients in Kudiezi injection based on UPLC-Q-TOF-MS technology:

[0023] 1 Introduction

[0024] Kudiezi injection is a plant of the genus Kudiezi in the family Asteraceae, Kudiezi. Ixeris sonchifolia Hance ] The whole plant is made by extracting and processing. According to the chemical substance group to which the identified compounds belong, a database including chemical name, molecular formula, structural formula, and accurate mass number is established, and the characteristic fragments and neutral loss of a certain type of compound with a corresponding public skeleton are summarized, which is applied to the original data of the fingerprint Analysis, and strive to achieve the purpose of rapid and accurate classification and identification. Nowadays, with the continuous development of data post-processing technology, Diagnostic fragments filter (PIF) and neutral loss filter (Neutral loss, NIF) have shown unique advant...

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Abstract

Based on UPLC‑Q‑TOF‑MS technology, the rapid classification and identification of chemical components in Kudiezi injection was realized, aiming to study flavonoids, organic acids, amino acids and nucleosides in Kudiezi injection. The UPLC‑Q‑TOF‑MS technology platform realizes the rapid classification and identification of chemical components in Kudiezi injection. In this study, the information of flavonoids, organic acids, amino acids and nucleosides in Kudiezi injection was firstly integrated, and the diagnostic fragments and neutral loss rules of these four categories of substances were found and summarized; at the same time, UPLC-Q ‑TOF‑MS technology performs mass spectrometry analysis on reference substances of different types of compounds to verify. Then, using the diagnostic fragmentation and neutral loss methods as screening and identification tools, a method for the rapid classification and identification of chemical components in Kudiezi injection was constructed.

Description

technical field [0001] The invention relates to the identification of chemical components in traditional Chinese medicine injections, that is, the rapid classification and identification of chemical components in Kudiezi injections is realized based on UPLC-Q-TOF-MS technology. Background technique [0002] In the prior art, the Kudiezi injection is Kudiezi, a plant of the genus Kudiezi in the family Asteraceae. Ixeris sonchifolia Hance ] The whole plant is made by extracting and processing. The chemical composition of Kudiezi is relatively complex. According to literature reports, its main components include terpenoids, flavonoids, coumarins, and sterols. Among them, the main active ingredients are affected by factors such as the place of origin, climate and ecological environment, and the ingredients contained in the injections made from Kudiezi from different places of origin are quite surprising. Studies have reported that polysaccharides extracted from various anima...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/62G01N30/02G01N27/626
Inventor 李遇伯袁磊杨彬邹敬韬
Owner TONGHUA HUAXIA PHARMA
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