42results about How to "Increased side effects" patented technology

The invention relates to a polymer composition loaded with a sirolimus compound or its derivative. The composition can have diversified forms. A necessary link includes preparing the sirolimus compound or its derivative and a polymer carrier into a micelle. Then according to needs, the micelle can be further prepared into a freeze-dried composition by a freeze-drying technology, or the micelle and other polymer and carrier can be prepared into a solid or semi-solid preparation. The polymer composition can be used for treating tumors, reducing rejection reactions after organ and tissue transplantation, promoting cell regeneration and repair, preventing excessive scar tissue growth after injury and preventing vascular restenosis and blood coagulation embolism, treating or inhibiting autoimmune diseases, and treating or inhibiting inflammation, etc.

The invention relates to a red nocardia rubra cell wall skeleton buccal tablet which has the active ingredient of red nocardia rubra cell wall skeleton and the auxiliary materials including trehalose, glycine, xylitol, sodium carboxy methyl cellulose, erythritol, gelatine powder and magnesium stearate.

The invention relates to a traditional Chinese medicine composition with a galactagogue effect and a preparation method thereof, and the composition comprises membranous milkvetch root, Chinese angelica, radix rehmanniae preparata, cowherb seed, pig nails and beautiful sweetgum fruit.

The invention relates to a novel process for preparing benzyl alcohol by alkali-free continuous hydrolysis of benzyl chloride. The process comprises the following steps of adding benzyl chloride, pure water and a specific mixed solvent of methylbenzene and cyclohexane into a primary normal-pressure reaction kettle according to a certain proportion, performing reaction for a certain time at certain temperature, continuing transferring a reaction product into a secondary pressure reaction kettle, adding an isopropylbenzene solvent, simultaneously adding methyl trioctyl ammonium chloride quaternary ammonium salt, continuing performing reaction for a certain time, cooling and settling obtained reaction liquid to separate an oil phase and an aqueous phase (containing benzyl alcohol and hydrochloric acid), and performing crude distillation and rectification on the oil phase to obtain a benzyl alcohol finished product. According to the process, a continuous feeding and discharging manner is adopted for reaction, and a corresponding solvent and a corresponding catalyst are combined, so that the yield rate of the product is increased, and the productivity is improved.

The invention discloses a probiotic preparation for conditioning intestinal flora imbalance of tumor patients after radiotherapy and chemotherapy and an application thereof, and relates to the technical field of probiotic preparations. The probiotic preparation comprises probiotics, vitamins, trace elements, proteins, traditional Chinese medicine extract, sugar and auxiliary components. The probiotics comprise the following components in parts by mass: 10 to 25 parts of bifidobacterium longum, 10 to 15 parts of bifidobacterium breve, 10 to 35 parts of bifidobacterium bifidum, 10 to 25 parts ofbifidobacterium adolescentis, 10 to 25 parts of lactobacillus acidophilus, 10 to 35 parts of lactobacillus fermentum, 10 to 20 parts of lactobacillus paracasei, 10 to 30 parts of lactobacillus plantarum, 10 to 15 parts of lactobacillus rhamnosus and 5 to 10 parts of streptococcus thermophilus.

The invention discloses a potato seed coating agent, which mainly comprises the following active ingredients in percentage by weight: 0.8 to 2.2 percent of compound sodium nitrophenolate serving as a plant growth regulator, 0.2 to 1.6 percent of raw alpha-sodium acetate serving as another plant growth regulator, and the balance of synergic aid and solvent which are allowed to be used in pesticideand can be accepted. Seeds are soaked and dressed, and a protective agent membrane is formed around the tomatoes so that the potato seed coating agent can prevent insects and diseases in the whole growth process of the potatoes, improve soil, fulfill the purposes of increasing the yield and improving the quality, and effectively relieve several contradictions that the plant diseases and insect pests have medicinal resistance on insecticide and germicide and the potatoes are not suitable for long-term storage after the fertilizer is applied and the yield is increased.

The invention discloses a traditional Chinese medicine for treating diabetic gastroparesis, belonging to the technical field of pure traditional Chinese medicine. The traditional Chinese medicine for treating diabetic gastroparesis comprises pseudostellaria root, Radix Astragali, Chinese yam, bighead atractylodes rhizome, cuttlefish bone, calcined clam shell, hedgehog skin, mutmeg, Hindu daturae flower, immature orange fruit, perilla stem, banksia rose, medicinal evodia fruit, bitter orange, officinal magnolia bark, finger citron, toosendan fruit, silktree albizia bark, vine of tuber fleeceflower, Chinese thorowax root, nutgrass galingale rhizome, radish seed, ginger, pinellia tuber, rehmannia root and hemp seed. A dose of the traditional Chinese medicine is taken each day and decocted twice; 350 to 450 ml of the obtained decoction is extracted and divided into two parts which are respectively taken after meal. Through combination of the above-mentioned bulk drugs, the traditional Chinese medicine exerts spleen-invigorating, qi-benefiting, blood circulation-promoting, blood stasis-dispelling, qi-rectifying, pain-relieving, stomach-harmonizing and adverse-rising energy-claming effects. The traditional Chinese medicine is better than the western medicine--cisapride, has the advantages of small side effects, flexibility in usage, suitability for long-term treatment and a treatment effective rate of more than 93% and is worth popularization and application.

The soft Chinese medicine capsule for treating chronic cholecystitis and gall-stone consists of soft capsule coating and contained matter. The contained matter includes dementholized mint oil and medicinal supplementary material capable of being mixed homogeneously with dementholized mint oil, and the supplementary material is selected from polyglycol-400, Tween-80, glycerine, vegetable oil, etc. The preparation has effectively controlled volatilization of dementholized mint oil, stable quality, homogeneously distributed medicine component, fast leaching, high bioavailability, and well masking of the special smell of dementholized mint oil for easy taking.

The invention discloses bitter gourd polypeptide for inhibiting tumor cell proliferation as well as a preparation method and application thereof. The preparation method comprises the following steps:step 1: chopping bitter gourds for later use; step 2: preparing a rough grinding material solution; step 3: freezing the rough grinding material solution at -40 to -80 DEG C; step 4: unfreezing; grinding and filtering through a screen mesh to prepare a fine grinding material solution; step 5: centrifuging in a freezing centrifugal machine and taking supernatant; step 6: centrifuging in a high-speed freezing centrifugal machine and taking supernatant; step 7: carrying out ultra-filtration, wherein the film covering diameter is 10 KD and filtrate with the diameter smaller than 10 KD is the bitter gourd polypeptide. According to the method provided by the invention, cell walls can be damaged to a certain extent and the dissolution rate of active substances is high; the activity of bitter gourd bioactive peptide obtained by combining an ultra-filtration technology is relatively high and a technology is easily industrialized. Meanwhile, the raw material bitter gourd has the advantages of safety for eating, no toxic side effect, high nutrient value and the like. Furthermore, the prepared bitter gourd polypeptide has the effect of inhibiting the tumor cell proliferation.

To provide an insulin resistance-improving agent, and the application thereof. The insulin resistance-improving agent contains an eggshell membrane component, for example, an eggshell membrane-containing powder or a soluble eggshell membrane component. Further, the eggshell membrane-containing powder to be used is a fine powder, and preferably has a volume average particle size of 6 μm or less, and / or a volume maximum particle size of 20 μm or less, but these particle sizes are not limited to the values.

The invention discloses an orally-taken tuckahoe polysaccharide sulfate-chitosan nanoparticle and a preparation method thereof. The preparation method comprises the following steps of: slowly adding a tuckahoe polysaccharide sulfate solution into a chitosan solution with stirring and continuously stirring, wherein at the same time, a mixed solution becomes turbid and a stable nano colloid solution is obtained; and spraying and drying the nano colloid solution by adopting a spraying and drying method at the high temperature of 70-120DEG C to obtain the orally-taken tuckahoe polysaccharide sulfate-chitosan nanoparticle. The nano-particle prepared by the preparation method is high in drug-loading rate, is small in particle size and is high in stability under the acidic environments of which the pH value is smaller than 7.5 and the temperature is about 37DEG C; and the nano-particle can be affined with small intestine and penetrates through the small intestine at the duodenum part in a form of complete nanoparticle and the medicament slowly releases in the blood.

The invention relates to a lactogenic traditional Chinese medicine composition and a preparation method thereof. The composition consists of radix bupleuri, radix paeoniae alba, scutellaria baicalensis, radix rhapontici, tetrapanax papyriferus, ligusticum wallichii and the seed of cowherb.

The invention discloses traditional Chinese medicine for treating psoriasis. The traditional Chinese medicine is prepared from, by weight, 12-15 g of radix angelicae sinensis, 10-12 g of cicada slough, 13-15 g of radix rehmanniae, 8-10 g of rhizoma anemarrhenae, 8-10 g of radix salviae miltiorrhizae, 20-22 g of cornu bubali, 8-10 g of radix sophorae flavescentis, 10-12 g of radix saposhnikoviae, 10-12 g of poria cocos, 10-12 g of cortex dictamni, 20-25 g of taraxacum, 8-10 g of radix paeoniae rubra, 8-10 g of lonicera japonica and 3-6 g of radix glycyrrhizae. The preparation method comprises the step of decoction. A preparation is decocted every day. According to the traditional Chinese medicine, the medicine is applied dialectically, and treatment for wind-heat-type and blood-heat-type psoriasis is fundamentally achieved. The traditional Chinese medicine has the functions of accelerating repairing of skin lesions, removing scales, relieving itching, removing freckles, shortening the treatment period and the like.

The invention relates to application of Metrnl in preventing and treating ulcerative colitis. According to the application, a DSS (Dextran Sulfate Sodium) induced ulcerative colitis model is established by using Metrnl intestinal epithelium specific knock-out mice and corresponding reference wild mice, and results show that the Metrnl intestinal epithelium specific knock-out mice are suffered fromulcerative colitis which is conspicuously more serious than that of the reference wild mice, the intestinal mucosa erosion degrees of the Metrnl intestinal epithelium specific knock-out mice are conspicuously higher than those of the reference wild mice, and a Metrnl protein can be used as a novel effective medicine for preventing and treating ulcerative colitis. The invention provides a novel method for preventing and treating ulcerative colitis, and in addition, since the Metrnl protein self is an endogenous protein of human bodies, the Metrnl protein has very small possible side effects onhuman bodies and is very high in security as a potential medicine.

This present invention discloses yeast hydrolysate to increase bone lengths such as growth plate, tibia, femur, etc. and weight and to stimulate growth hormone release. According to one aspect of the present invention, the yeast hydrolysate acquired by the processes including a hydrolysis step to add 0.1 to 3 % (w / v) of proteases to yeast or of autolysis substance of yeast; and a separation step to separate materials with the 10,000-30,000 Dalton molecular weight from the' supernatant of the said yeast hydrolysate is suggested. The said yeast hydrolysate is safe and has no side effect for intake.

The invention discloses a chewable tablet for improving anoxia endurance and a preparation method thereof. The chewable tablet is prepared from the following raw materials in parts by mass: 50-60 parts of sea cucumbers, 35-40 parts of American ginseng, 10-15 parts of Chinese wolfberries, 50-80 parts of rhodiola rosea, 12-14 parts of rhizoma polygonati, 5-8 parts of sea buckthorn seed oil, 0.1-0.3part of vitamin E, 10-15 parts of stachyose, 60-70 parts of bovine colostrum and 3-8 parts of dextrin. The preparation method comprises the following preparation steps: (1) treatment of raw materials;(2) preparation of soft materials; (3) granulation, drying and sorting of granules; (4) uniform stirring; (5) tabletting; (6) inspection; (7) sterilization; and (8) packaging. The chewable tablet forimproving anoxia endurance adopts a scientific formula of medicinal and edible dual-purpose raw materials and has no side effects, and the prepared chewable tablet can effectively promote blood circulation, increase the blood oxygen content, improve metabolism of an organism, eliminate accumulation of lactic acid, help relieving of fatigue, improve the anoxia symptoms and restore physical strength and has an obvious effect of improving the anoxia endurance.

The invention discloses a euphausia superba oil health capsule capable of reducing blood fat. The euphausia superba oil health capsule is prepared from euphausia superba oil and traditional Chinese herbal medicine raw materials through scientific compatibility; a preferred formula of the euphausia superba oil health capsule comprises the following components: 30-40 parts of euphausia superba oil, 15-20 parts of radix bupleuri, 15-18 parts of fructus lycii, 10-14 parts of rhizoma alismatis, 8-10 parts of stevia rebaudiana, 8-10 parts of radix glycyrrhizae, 6-10 parts of rheum officinale, 4-8 parts of rhizoma curcumae longae, 5-8 parts of rhizoma polygoni cuspidati, 4-6 parts of lucid ganoderma, 4-6 parts of semen cassia, 4-6 parts of fructus crataegi, 3-5 parts of fiveleaf gynostemma herb and 2-3 parts of ginseng; the components are allocated, mixed, sterilized and loaded into a capsule so as to prepare the capsule. The euphausia superba oil health capsule has the advantages that the capsule has the significant functions of regulating blood fat, enhancing immunity, resisting fatigue and prolonging life due to the synergy between the euphausia superba oil and the traditional Chinese herbal medicines, and the capsule is safe, is free of side effects and convenient to take, and has a good market application prospect.

The present invention discloses an aging delaying rose flower marine functional health-care beverage which is prepared from a scientific matching of rose flowers, abalones and Chinese herbal medicinal raw materials, and preferably 20-30 parts of rose flowers, 20-30 parts of abalones, 5-10 parts of radix scutellariae, 5-10 parts of epimedium herbs, 2-5 parts of ginsengs, 10-15 parts of acanthopanax senticosus roots, 3-5 parts of dandelions, 3-5 parts of licorice, 2-3 parts of fallopia multiflora, 3-5 parts of cordyceps sinensis, and 3-5 parts of stevia rebaudiana. The health-care beverage is prepared by enzymatic hydrolysis, extraction, mixing, blending, filling and sterilization processes. The advantages of the health-care beverage are that by a synergistic reaction of the rose flowers, abalones and Chinese herbal medicines, the product has significant efficacies of preventing aging, replenishing qi and tonifying, supporting healthy energy, preventing fatigue, enhancing immunity, prolonging life, etc., is safe without side effects, is convenient for consumption, and has relative good market prospects.

The invention discloses a montmorillonite inlaid liposome preparation and a preparation method thereof. According to the invention, montmorillonite is used as a drug carrier and is inlaid into the liposome so as to obtain a novel sustained drug release preparation montmorillonite inlaid liposome. The prepared liposome has good biological compatibility and sustained release performance, and can improve the bioavailability and side effect of drugs. Drugs can be released through ion-exchange action, the release rate of cationic type drugs is slowed down, and the side effects are reduced, thus being in favor of enhancing the drug bioavailability.

The invention relates to isolation, identification and application of a Fabricius bursa active hexapeptide for promoting an immunoreaction of avian influenza and / or a Newcastle disease bivalent vaccine. The Fabricius bursa active hexapeptide has an amino acid composition of Lys Gly Asn Arg Val Tyr, has a simple structure and is extremely weak in immunogenicity. The active peptide has the functionof promoting the immune response of the vaccine and can promote the antibody reaction against the AIV antigen and the antibody reaction against the NDV antigen in the mouse in the mouse immunization experiment. The active peptide can promote the cellular immune response, improve lymphocyte viability and an antigen presentation reaction and improve the vaccine immunopotency, can be used as a vaccine adjuvant or immunopotentiator in animal vaccine application research, can improve the immune response of animal organisms to specific antigens, can improve the immune efficacy of vaccines and can improve the ability of animal organisms resisting epidemic disease infection.

The invention belongs to the technical field of pure traditional Chinese medicine and discloses a traditional Chinese medicine for treating diabetic gastroparesis. Composed of heterophylla, astragalus, yam, Atractylodes macrocephala, cuttlefish bone, calcined corrugated seeds, hedgehog skin, nutmeg, Yangjinhua, citrus aurantium, stalk, woody, evodia, citrus aurantium, magnolia officinalis, bergamot, toosendan, Composition of Albizia Barbadensis, Yejiaovine, Bupleurum, Rhizoma Cyperi, Raisin Seed, Ginger, Pinellia, Rehmannia glutinosa, and Hemp Seed. Take 1 dose per day, decoct 2 times, take 350~450ml of juice, and take it after meals in 2 divided doses. The combination of the above drugs has the effects of invigorating the spleen and replenishing qi, promoting blood circulation and removing blood stasis, regulating qi and relieving pain, harmonizing the stomach and reducing adverse effects. The traditional Chinese medicine formula is superior to the western medicine cisapride, has few side effects, is flexible to use, is suitable for long-term treatment, and has an effective rate of more than 93%, and is worthy of popularization and application.

The invention discloses health-care wine, which is prepared by white spirit and a soaked drug in mass ratio of 1000: (100-200), wherein the soaked drug comprises the following components in weight parts: 20-30 parts of fleece-flower root, 20-30 parts of saffron crocus, 20-30 parts of milk vetch, 20-30 parts of licorice root, 10-20 parts of cogongrass rhizome, 10-20 parts of notopterygium root, 10-20 parts of figwort, 5-15 parts of shrubalthea bark, 5-15 parts of nard, and 5-15 parts of dried rehamnnia root. The health-care wine adopts the drugs which are elaborately selected and have higher nutritional and medical values; has the health-care functions such as dispelling the wind and eliminating the dampness, nourishing vital energy and freeing channels, relaxing the muscles and stimulating the blood circulation, reinforcing the spleen and warming the kidney, and enhancing the resistance; has no side effect; and is widely applicable.

The invention relates to application of Metrnl in preventing and treating ulcerative colitis. According to the application, a DSS (Dextran Sulfate Sodium) induced ulcerative colitis model is established by using Metrnl intestinal epithelium specific knock-out mice and corresponding reference wild mice, and results show that the Metrnl intestinal epithelium specific knock-out mice are suffered fromulcerative colitis which is conspicuously more serious than that of the reference wild mice, the intestinal mucosa erosion degrees of the Metrnl intestinal epithelium specific knock-out mice are conspicuously higher than those of the reference wild mice, and a Metrnl protein can be used as a novel effective medicine for preventing and treating ulcerative colitis. The invention provides a novel method for preventing and treating ulcerative colitis, and in addition, since the Metrnl protein self is an endogenous protein of human bodies, the Metrnl protein has very small possible side effects onhuman bodies and is very high in security as a potential medicine.

The invention discloses composite abalone and trepang liquid having the efficacy of reducing blood fat. The composite abalone and trepang liquid is prepared from the raw materials of abalones, holothurin and Chinese herbal medicines in scientific concerted application, preferably a formula of 30-40 parts of trepang, 15-20 parts of abalones, 15-18 parts of Chinese wolfberry, 10-14 parts of cortex phellodendri, 8-10 parts of stevia rebaudiana, 8-10 parts of licorice roots, 6-10 parts of haws, 4-8 parts of bighead atractylodes rhizomes, 5-8 parts of corn stigmas, 4-6 parts of eucommia ulmoides, 4-6 parts of semen cassiae, 4-6 parts of Chinese angelica, 3-5 parts of mulberry, and 2-3 parts of maifan stones according to the technologies of performing enzymolysis on the abalones and the trepang to obtain abalone and trepang enzymatic hydrolysate, leaching Chinese herbal medicines to obtain Chinese herbal medicine extract, mixing the abalone and trepang enzymatic hydrolysate and the Chinese herbal medicine extract to obtain composite abalone and trepan liquid, regulating the pH of the composite abalone and trepan liquid, filling bottles with the composite abalone and trepan liquid of which the pH is regulated, and sterilizing the bottled composite abalone and trepan liquid. The product of the composite abalone and trepang liquid has the advantages that through the synergistic effect of the abalones, the holothurin and the Chinese herbal medicines, the product has the outstanding efficacies of regulating blood fat, enhancing the immunity, resisting weariness, prolonging life and the like, is safe and free from side effects, is convenient to eat, and has a better market application prospect.

A process for preparing ethyldiamine tetraacetonitrile and ethyldiamine tetraacetic acid includes such steps as regulating the pH value of ethyldiamine solution to 6-8, adding hydroxyacetonitrile, reacting to obtain ethyldiamine diacetonitrile, heating to 60-100 deg.C, adding hydroxyaceto nitrile reacting to generate ethyldiamine tetraacetonitrile, cooling, filter, hydrolyzing in alkaline aqueous solution to obtain ethyldiamine tetraacetate, and adding acid to make pH=1-3 for obtaining ethyldiamine tetraacetic acid.

The invention discloses a composite scallop and holothurin liquid with blood fat regulating efficacy. The composite scallop and holothurin liquid is prepared from scallop, holothurin and Chinese herbal medicines according to scientific compatibility and is preferably prepared from 30-40 parts of the holothurian, 15-20 parts of the scallop, 15-18 parts of boxthorn fruits, 10-14 parts of scutellaria baicalensis, 8-10 parts of stevia rebaudiana, 8-10 parts of liquorice, 6-10 parts of hawthorn fruits, 4-8 parts of rhizoma atractylodis macrocephalae, 5-8 parts of corn stigma, 4-6 parts of herba epimedii, 4-6 parts of cassia seeds, 4-6 parts of Chinese angelica, 3-5 parts of the hawthorn fruits and 2-3 parts of medical stones according to a preparation technology which includes the steps of enzymolysis, soaking, extracting, mixing, blending, filling and sterilization. By the aid of synergistic effects of the scallop, the holothurian and the Chinese herbal medicines, the composite scallop and holothurin liquid has the advantages of remarkable efficacy of regulating blood fat, boosting immunity, resisting fatigue, prolonging life and the like, and is safe, free from side effect, convenient to take and good in market application prospect.

The invention relates to isolation, identification and application of a Fabricius bursa active hexapeptide for promoting an immunoreaction of avian influenza and / or a Newcastle disease bivalent vaccine. The Fabricius bursa active hexapeptide has an amino acid composition of Lys Gly Asn Arg Val Tyr, has a simple structure and is extremely weak in immunogenicity. The active peptide has the functionof promoting the immune response of the vaccine and can promote the antibody reaction against the AIV antigen and the antibody reaction against the NDV antigen in the mouse in the mouse immunization experiment. The active peptide can promote the cellular immune response, improve lymphocyte viability and an antigen presentation reaction and improve the vaccine immunopotency, can be used as a vaccine adjuvant or immunopotentiator in animal vaccine application research, can improve the immune response of animal organisms to specific antigens, can improve the immune efficacy of vaccines and can improve the ability of animal organisms resisting epidemic disease infection.

The invention relates to a lactogenic traditional Chinese medicine composition and a preparation method thereof. The composition consists of radix bupleuri, radix paeoniae alba, scutellaria baicalensis, radix rhapontici, tetrapanax papyriferus, ligusticum wallichii and the seed of cowherb.

The invention relates to a new process for preparing benzyl alcohol by continuous hydrolysis of benzyl chloride without alkali. In the invention, benzyl chloride, pure water, a specific mixed solvent of toluene and cyclohexane are added to a first-stage normal-pressure reaction kettle in a certain proportion After reacting at a certain temperature for a certain period of time, it is continuously transferred to a secondary pressurized reactor, adding cumene solvent, and adding trioctylmethyl ammonium chloride quaternary ammonium salt to continue the reaction for a certain period of time. After cooling and settling, the oil phase and water phase (containing benzyl alcohol and hydrochloric acid) are separated, and the oil phase is subjected to crude distillation and rectification to obtain the finished product of benzyl alcohol. The invention adopts the continuous feeding and discharging mode to react, and combines corresponding solvents and catalysts to improve the output rate of products and increase production capacity.