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Red nocardia rubra cell wall skeleton buccal tablet and preparation method thereof

A technology of Nocardia rubrum and cell wall, which is applied in the field of Nocardia rubra cell wall skeleton (N-CWS) preparation of buccal tablets and its preparation field, can solve the problem of high absorption requirements, achieve good absorption effect, avoid damage, The effect of convenient storage

Active Publication Date: 2013-01-30
FUJIAN COSUNTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the oral absorption requirements of the cell wall skeleton of Nocardia rubrum are high, that is, rapid absorption is required, and good taste and stability are required. The existing oral preparations are difficult to meet the requirements.

Method used

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  • Red nocardia rubra cell wall skeleton buccal tablet and preparation method thereof
  • Red nocardia rubra cell wall skeleton buccal tablet and preparation method thereof
  • Red nocardia rubra cell wall skeleton buccal tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] A kind of Nocardia rubrum cell wall skeleton buccal tablet of the present invention, its formula is:

[0070] Nocardia rubrum cell wall skeleton (N-CWS) 100 μg

[0071] All the other are pharmaceutical auxiliary materials, and the weight ratio of said auxiliary materials is,

[0072]

[0073] Its preparation process is as follows:

[0074] (1) Take gelatin powder and pulverize below 0°C, pass through a 100-mesh sieve for later use.

[0075] (2) Weigh xylitol, sodium carboxymethylcellulose and erythritol according to the formula weight ratio, and mix them evenly.

[0076] (3) Add an appropriate amount of distilled water to the cell wall skeleton of Nocardia rubrum in the prescribed amount, use ultrasonic technology to fully disperse the drug in the medium, add trehalose and glycine in the prescribed amount, and mix well to obtain N-CWS slurry.

[0077] (4) Add the N-CWS slurry to the mixture of xylitol, sodium carboxymethylcellulose and erythritol under stirring, a...

Embodiment 2

[0083] A kind of Nocardia rubrum cell wall skeleton buccal tablet of the present invention, its formula is:

[0084] Nocardia rubrum cell wall skeleton (N-CWS) 200 μg

[0085] All the other are pharmaceutical auxiliary materials, and the weight ratio of said auxiliary materials is,

[0086]

[0087] The preparation method is the same as in Example 1.

Embodiment 3

[0089] A kind of Nocardia rubrum cell wall skeleton buccal tablet of the present invention, its formula is:

[0090] Nocardia rubrum cell wall skeleton (N-CWS) 400 μg

[0091] All the other are pharmaceutical auxiliary materials, and the weight ratio of said auxiliary materials is,

[0092]

[0093] The preparation method is the same as in Example 1.

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Abstract

The invention relates to a red nocardia rubra cell wall skeleton buccal tablet which has the active ingredient of red nocardia rubra cell wall skeleton and the auxiliary materials including trehalose, glycine, xylitol, sodium carboxy methyl cellulose, erythritol, gelatine powder and magnesium stearate.

Description

technical field [0001] The invention relates to the technical field of medical bioengineering, in particular to the preparation of buccal tablets by using Nocardia rubrum cell wall skeleton (N-CWS) and a preparation method thereof. Background technique [0002] Nocardia rubra cell wall skeleton (N-CWS) is prepared from Nocardia rubra 03-PO-8 through biological fermentation, cell disruption, protease treatment and solvent extraction. Currently, there are injection products on the market. [0003] The cell wall skeleton of Nocardia rubra is prepared from Nocardia rubra through fermentation, cell crushing, enzyme treatment, solvent extraction, etc. It is a white powder with stable properties and insoluble in water, methanol and other organic solvents . Contains lipid compounds (171%), polysaccharides (arabinogalactan 463%), mucopeptides (mainly alanine, glutamic acid, diaminopimelic acid, glucosamine, muramic acid) Similar to biological products BCG, CP, interferon, thymus fa...

Claims

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Application Information

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IPC IPC(8): A61K35/74A61K9/20A61K47/42A61P1/02A61P1/04A61P1/16A61P11/04A61P31/16A61P31/20
Inventor 陈仕魁杨喜鸿庄晓东苏葳
Owner FUJIAN COSUNTER PHARMA
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