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67results about How to "Mitigate the problem of drug resistance" patented technology

CD19 and PD-L1 double-target chimeric antigen receptor and application thereof

The invention provides a CD19 and PD-L1 double-target chimeric antigen receptor and an application thereof. The chimeric antigen receptor comprises an antigen binding structural domain, a transmembrane structural domain and a signal transduction structural domain, wherein the antigen binding structural domain comprises an anti-CD19 single-chain antibody and an anti-PD-1 antibody. The anti-CD19 andPD-L1 double-target chimeric antigen receptor disclosed by the invention not only can recognize CD19 positive tumor cells in a targeting manner, but also can relieve the immunosuppression effect of PD-L1 on the surfaces of the tumor cells on T cells, overcomes the immune escape mechanism of the tumor cells, and alleviates the drug resistance problem of CAR-T treatment.
Owner:GUANGDONG ZHAOTAI INVIVO BIOMEDICINE CO LTD

Compound plant growth regulator and application thereof

The invention discloses a compound plant growth regulator and application thereof. The compound plant growth regulator comprises, by weight, 0.001-1.0 part of brassinolide, 10-20 parts of a brown algaextract, 15-35 parts of a reynoutria sachalinensis extract, 15-35 parts of a radix curcumae extract, 10-20 parts of a mimosa pudica extract and 10-20 parts of an oak stem and leaf alcohol extract. According to the growth regulator, the environment-friendly growth regulator brassinolide compound is combined with the medicine materials and plant extracts, and all the medicine components have a sufficient synergistic effect; the growth regulator has a effect of restraining various bacteria, fungi and viruses and has remarkable effects of effectively promoting the growth and development of vegetable crops (cucumbers, chilli, tomatoes or the like) and the absorption and transferring of nutrients, prompting the crop maturity and improving the color, luster, sugar degree and appearance glossiness.
Owner:江西鑫邦科技有限责任公司

Citrus insecticide

The invention relates to a plant insecticide and particularly relates to a citrus insecticide. The citrus insecticide is prepared from the following components: citrus peels, hydrogen peroxide, baking soda, tetramethrin, glycine, sodium hydroxide, Chinese prickly ash liquid, cordate houttuynia and fulvic acid. The citrus insecticide has the characteristics of high speed, long lasting period, small dosage and environment friendliness; insect resistance is effectively inhibited and a current problem of insect drug resistance is alleviated to the greatest extent, so that the dosage of pesticides is reduced and the influences on the environment are also alleviated; and the citrus insecticide also has the characteristics of fragrant taste, no harms to people and livestock, wide insecticidal spectrum and no residues.
Owner:SICHUAN FENGCHENG MODERN AGRI SCI & TECH CO LTD

Cartap contained EW (emulsion in water) and application

The invention belongs to the technical field of pesticide compound, particularly relates to a cartap contained EW (emulsion in water) and application. Effective ingredients of the composition are bifenthrin and cartap, wherein the weight ratio of cartap to bifenthrin is (1:1) to (1:10). The compound combination effectively resists the problem about the production of pest resistance, thereby mitigating the conventional resistance to drugs of pests to the largest extent; less use of pesticide reduces influence on the environment, and the trend of green environmental protection in future society is conformed; the composition provided by the invention achieves the optimal crop protection effect.
Owner:山东中新科农生物科技有限公司

Three-element compounding agent namely bensulfuron methyl.pretilachlor.pendimethalin for preventing and removing drought direct sowing rice field weeds

The invention discloses a three-element compounding agent namely bensulfuron methyl.pretilachlor.pendimethalin for preventing and removing drought direct sowing rice field weeds. The three-element compounding agent is characterized by being prepared by taking bensulfuron methyl, pretilachlor and pendimethalin as active ingredients and then adding a safener namely fenclorim. The mixing ratio of bensulfuron methyl to pretilachlor to pendimethalin is (7.5-60):(75-600):(30-240) (ga.i./ha), the ratio of pretilachlor to the safener namely fenclorim in the compounding agent is (3:1)-(3:2), the application time of the compounding agent is 3-5 days after sowing cultivated rice, the field recommended dosage is 337.5-562.5ga.i./ha, and excess water should be avoided in 24 hours after application, otherwise, pesticide hazards are caused to the cultivated rice. The three-element compounding agent disclosed by the invention can be used for greatly expanding the weed control spectrum, reducing the number of application and the quantity of work, reducing the weeding cost, improving the economic benefit, reducing the pesticide hazards, improving the safety and relieving the drug resistance of weeds.
Owner:NANJING AGRICULTURAL UNIVERSITY

Composition containing methoprene and application thereof

The invention belongs to the technical field of pesticide and insecticide compounding, and in particular, relates to a composition containing methoprene and an application thereof. The composition has the effective ingredients of methoprene and permethrin, wherein the mass ratio of the effective ingredient methoprene to the effective ingredient permethrin is 2 to (5-15); the composition can be obviously synergistic, has significant prevention and treatment effects, alleviates the conventional problem of pest drug resistance to a greatest extent, thereby reducing the dosage of pesticides and reducing prevention and treatment costs; and the composition is convenient to spray, has less pollution to the environment, and adapts to large-area farming ways.
Owner:JINAN SHUNHAO BIOTECH CO LTD

Water dispersible granule containing etrimfos and application thereof

The invention specifically relates to a water dispersible granule containing etrimfos and application thereof, belonging to the technical field of complex formulation of pesticides. The water dispersible granule comprises the following active components: etrimfos and crotoxyphos in a ratio of 1: 3-15. The water dispersible granule is an environment-friendly dosage form, has obvious synergistic effect and substantial prevention and treatment effect, greatly reduces the usage amount of pesticide and maximally alleviates the problem of pest resistance to insecticides in the prior art.
Owner:JINAN SHUNHAO BIOTECH CO LTD
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