67results about How to "Mitigate the problem of drug resistance" patented technology

The invention belongs to the technical field of agricultural fungicides, in particular to a bactericidal composition containing cyazofamid and an application thereof. The composition adopts the cyazofamid and another fungicide component B for complexing, the fungicide B is at least one selected from propamocarb, flumorph, cymoxanil, dimethomorph, fosetyl-aluminum, oxadixyl, metalaxyl, metalaxyl-Mand chlorothalonil, the composition is used for controlling a variety of diseases caused by pathogenic fungi and particularly applicable to controlling downy mildew, blight, downy blight and the likeof fruits, vegetables and a plurality of crops, and the composition has significant synergy and can better overcome and retard the drug resistance of pathogens.

The invention discloses a kresoxim-methyl and pyrimethanil compound fungicide composite fumigant and an application of the fumigant. The kresoxim-methyl and pyrimethanil compound fungicide composite fumigant is characterized by comprising pyrimethanil and kresoxim-methyl, wherein the weight ratio of pyrimethanil to kresoxim-methyl is (8 to 1)-(1 to 5). According to the optimization scheme, kresoxim-methyl and pyrimethanil account for 0.1-60wt% of the fumigant in total. By virtue of the kresoxim-methyl and pyrimethanil compound fungicide composite fumigant, the same effect can be achieved by only using 1 / 2-2 / 3 of active ingredients of other preparations of the same pesticide; the pesticide is saved; the fumigant is high in effect, low in residues and safe to use; the most direct beneficial effect on the agricultural production is that the application cost per mu is reduced and the excellent prevention and treatment effect is achieved.

The invention relates to a seed coating agent, in particular to a seed ginger seed coating agent for preventing ginger wilt. The seed ginger seed coating agent provided by the invention adopts active ingredients of low-toxicity reagents, which are safe to non-target organisms and environment, do not have adverse harm to human bodies and are suitable for the seed ginger treatment. Particularly, a compound recipe used by the seed coating agent can effectively utilize the efficient sterilizing effect of bromothalonil, meanwhile, a good protection effect of pyrimidine nucleoside antibiotics is utilized, and the medicine effect is enhanced, so the seed ginger seed coating agent has good effects of preventing and treating the ginger wilt. Meanwhile, the sterilization mechanisms of bromothalonil, pyrimidine nucleoside antibiotics and the zhongshengmycin are diverse from each other, and the generation of medicine resistance of ginger wilt germs can be effectively relieved.

The invention relates to a wettable powder compounded by dimethomorph and polyoxin and a preparation method thereof. The wettable powder is compounded by the following components: 10-50% of dimethomorph and 2-10% of polyoxin (preferably 20-30% of dimethomorph and 2-5% of polyoxin), a dispersing agent, a wetting agent, an adjuvant and a carrier. The two effective ingredients can produce synergistic effect, thus effectively reducing the single dose, enlarging the bactericidal spectrum, lowering the chemical injury, obviously improving the control effect on germs, relieving the drug resistance problem of pathogenic bacteria and lowering the control cost; and the effective ingredients have good control effect on downy mildew, epidemic diseases, leaf spot, gray mold and the like of a pluralityof crops such as fruit trees, vegetables, field crops and the like; and the obtained wettable powder has good environmental compatibility and good popularization prospect.

The invention provides a CD19 and PD-L1 double-target chimeric antigen receptor and an application thereof. The chimeric antigen receptor comprises an antigen binding structural domain, a transmembrane structural domain and a signal transduction structural domain, wherein the antigen binding structural domain comprises an anti-CD19 single-chain antibody and an anti-PD-1 antibody. The anti-CD19 andPD-L1 double-target chimeric antigen receptor disclosed by the invention not only can recognize CD19 positive tumor cells in a targeting manner, but also can relieve the immunosuppression effect of PD-L1 on the surfaces of the tumor cells on T cells, overcomes the immune escape mechanism of the tumor cells, and alleviates the drug resistance problem of CAR-T treatment.

The invention relates to the technical field of a pesticide bactericide preparation, in particular to a combination for preventing and curing downy mildew of fruits and vegetables and an aqueous emulsion thereof and a processing preparation method of the aqueous emulsion. The preparation method helps recompose a triazole bactericide with propamocarb hydrochloride, takes the preparation mode of the aqueous emulsion, and optimizes and adjusts the preparation method of the aqueous emulsion, thus improving the original preparation technology, better preventing and curing downy mildew of fruits and vegetables such as cucumbers, grapes and the like, improving the preventing and curing effect and decreasing usage amount of drugs and drug application times.

The invention provides a composite bacterial powder, a composite microbial agent thereof and a preparation method and application of the composite microbial agent. The composite bacterial powder is formed by compounding spore powder of trichoderma harzianum and spore powder of isaria fumosorosea. Isaria fumosorosea and trichoderma harzianum are combined for use, diseases and insect pests such as aphids, cabbage caterpillars, whiteflies, tomato leaf mold, pepper phytophthora blight and cucumber fusarium wilt can be effectively prevented and controlled, and the method has the advantages of beingstable in effect, safe, efficient and the like. The agricultural composite microbial agent can effectively reduce the use amount of pesticides, reduce pesticide residues and delay the pesticide resistance of pests, and has the potential of replacing part of chemical pesticides.

The invention discloses a potato seed coating agent, which mainly comprises the following active ingredients in percentage by weight: 0.8 to 2.2 percent of compound sodium nitrophenolate serving as a plant growth regulator, 0.2 to 1.6 percent of raw alpha-sodium acetate serving as another plant growth regulator, and the balance of synergic aid and solvent which are allowed to be used in pesticideand can be accepted. Seeds are soaked and dressed, and a protective agent membrane is formed around the tomatoes so that the potato seed coating agent can prevent insects and diseases in the whole growth process of the potatoes, improve soil, fulfill the purposes of increasing the yield and improving the quality, and effectively relieve several contradictions that the plant diseases and insect pests have medicinal resistance on insecticide and germicide and the potatoes are not suitable for long-term storage after the fertilizer is applied and the yield is increased.

The invention belongs to the technical field of pesticide compounding and particularly relates to thiocyclam-containing emulsion in water and application. The thiocyclam-containing emulsion in water as a composition consists of bifenthrin and thiocyclam as effective constituents, wherein the weight ratio of thiocyclam to bifenthrin is 1:1 to 1:10; the thiocyclam-containing emulsion in water as the compounding composition can be used to inhibit the problem of drug resistance generation of pests effectively, alleviate the problem of pesticide resistance of pests at present maximally to further reduce the consumption of pesticides and also alleviate the influence to the environment, and is in conformity with the tendency of environment protection in the society in future; and the thiocyclam-containing emulsion in water as the composition achieves the best crop protection effect..

The invention discloses a compound plant growth regulator and application thereof. The compound plant growth regulator comprises, by weight, 0.001-1.0 part of brassinolide, 10-20 parts of a brown algaextract, 15-35 parts of a reynoutria sachalinensis extract, 15-35 parts of a radix curcumae extract, 10-20 parts of a mimosa pudica extract and 10-20 parts of an oak stem and leaf alcohol extract. According to the growth regulator, the environment-friendly growth regulator brassinolide compound is combined with the medicine materials and plant extracts, and all the medicine components have a sufficient synergistic effect; the growth regulator has a effect of restraining various bacteria, fungi and viruses and has remarkable effects of effectively promoting the growth and development of vegetable crops (cucumbers, chilli, tomatoes or the like) and the absorption and transferring of nutrients, prompting the crop maturity and improving the color, luster, sugar degree and appearance glossiness.

The invention relates to application of two isoflavone compounds in prevention and treatment of plant diseases, belonging to the technical field of botanical bactericides. The compounds are 4'-O-methyl glabridin and glycyrrhizin B respectively, can be separated and extracted from glycyrrhiza plants, and can also be prepared through a chemical synthesis or biosynthesis method. The compounds can effectively inhibit sclerotinia sclerotiorum, fusarium graminearum, botrytis cinerea, Chinese wolfberry colletotrichum gloeosporioides, rhizoctonia solani, fusarium oxysporum, magnaporthe grisea and xanthomonas oryzae pv. Oryzae, and botanical bactericides prepared by using the compounds as active components can be used for preventing and treating plant diseases caused by the above pathogens. The technical scheme provided by the invention has the characteristics of environmental friendliness, relative safety to non-target organisms and the like, and can relieve the problem of drug resistance whenbeing alternately used with existing bactericides.

The invention belongs to the technical field of biology, and particularly relates to a metarhizium anisopliae IPPMHBC-009 complex microbial agent and application thereof. The preservation number of the metarhizium anisopliae (Metarhizium Anisopliae) IPPMHBC-009 is CGMCC No.16000, and the metarhizium anisopliae IPPMGBC-009 has good median lethal time and bombys batryticatus rate for oedaleus decorus asiaticus and dasyhippus barbipes. The metarhizium anisopliae IPPMHBC-009 complex microbial agent and the application thereof have the advantage that through the combined application of the metarhizium anisopliae IPPMHBC-009 and chlorantraniliprole, the fast-acting property of killing insects and insect killing rate can be significantly improved.

The invention belongs to the technical field of pesticide compounding, in particular to an emulsion in water of theta-cypermethrin and fenoxycarb and application thereof. Effective components of the composition are theta-cypermethrin and fenoxycarb, wherein the weight ratio of the theta-cypermethrin to the fenoxycarb is 1: 1-1: 5. The compounded composition effectively resists the problem of resistance generation of injurious insects, and relieves the present problem of drug resistance of the injurious insects to the greatest extent, so that the dosage of pesticide is reduced, the influence to the environment is relieved, and the environmental protecting trend of the future society is met; and the composition of the invention obtains the optimal plant protecting effect.

The invention relates to an application of psoralen in preventing and treating plant bacterial diseases, and belongs to the technical field of botanical bactericides. The compound can effectively inhibit the growth of xanthomonas, such as Xanthomonas oryzae pv.oryzae, Xanthomonas oryzae pv.oryzicola, Xanthomonas campestris pv.campestris and the like, and plant source bactericide processed by the compound as an active ingredient can be used for preventing and treating plant bacterial diseases caused by xanthomonas. The compound and other bactericide can be alternately used to delay the generation of drug resistance.

The invention relates to a plant insecticide and particularly relates to a citrus insecticide. The citrus insecticide is prepared from the following components: citrus peels, hydrogen peroxide, baking soda, tetramethrin, glycine, sodium hydroxide, Chinese prickly ash liquid, cordate houttuynia and fulvic acid. The citrus insecticide has the characteristics of high speed, long lasting period, small dosage and environment friendliness; insect resistance is effectively inhibited and a current problem of insect drug resistance is alleviated to the greatest extent, so that the dosage of pesticides is reduced and the influences on the environment are also alleviated; and the citrus insecticide also has the characteristics of fragrant taste, no harms to people and livestock, wide insecticidal spectrum and no residues.

The invention discloses bacillus with a boxthorn leaf blight preventing effect. The bacillus is antagonistic bacillus LKYLW-5 and belongs to bacillus atrophaeus, the length of a 16 S rDNA nucleotide sequence of the bacillus is 1492bp, the bacillus is preserved in China General Microbiological Culture Collection Center on November 29th 2018, and a preservation number is CGMCC NO.16837. The bacillusdisclosed by the invention is obtained from cultivated soil of a boxthorn planting area through slab confrontation culture screening; the bacillus can be applied to preventing and treating boxthorn leaf blight caused by alternaria alternata; the bacillus can inhibit mycelia growth of boxthorn leaf blight bacteria and germination of alternaria alternata spores; after boxthorn leaf blight pathogenic bacteria are inoculated to boxthorn plants, a preventing effect is 62.96%, and a treating effect is 60.15%; the bacillus has high-efficiency and obvious preventing and treating effects on the boxthorn leaf blight, is a biological prevention and control potential strain with high preventing efficiency and good environmental safety and has good development and application prospects.

The invention belongs to the technical field of pesticide compound, particularly relates to a cartap contained EW (emulsion in water) and application. Effective ingredients of the composition are bifenthrin and cartap, wherein the weight ratio of cartap to bifenthrin is (1:1) to (1:10). The compound combination effectively resists the problem about the production of pest resistance, thereby mitigating the conventional resistance to drugs of pests to the largest extent; less use of pesticide reduces influence on the environment, and the trend of green environmental protection in future society is conformed; the composition provided by the invention achieves the optimal crop protection effect.

The invention discloses an insecticide for killing potato beetles and a preparation method thereof. The insecticide is prepared from, by weight, 15-25 parts of azadirachtin, 10-15 parts of avermectin, 20-30 parts of carbosulfan, 0.5-1.5 parts of stabilizer, 0.05-0.1 part of active polypeptide, 1-5 parts of dispersant, 1-5 parts of emulsifier, 1-5 parts of auxiliary solvent, 2-8 parts of filler, and 20-30 parts of water. The insecticide for killing potato beetles has the advantages that the insecticide belongs to the pesticide compound with different insecticidal mechanisms, has more action point locations for the potato beetles, is quick in effect and long in duration, and can effectively control the potato beetles; the problem of pest resistance is effectively prevented, the problem of pest resistance at present is alleviated to the largest extent, so that the amount of pesticide used is reduced, the impact on the environment is also eased, and the insecticide is in line with the social green trend of environmental protection.

The invention relates to a plant pesticide, in particular to a citrus pesticide. The citrus pesticide comprises the following components, by weight, 5-10 parts of acephate, 1-3 parts of hydrogen peroxide, 10-20 parts of cut tobacco,15-25 parts of tetramethrin, 10-20 parts of glycine, 20-30 parts of garlic powder, 12-30 parts of Chinese pricklyash solution, 10-15 parts of purslane and 5-9 parts offulvic acid. The citrus pesticide has fast acting speed, good stability and long effective period, effectively counteracts the generation of pest resistance and alleviates the problem of the current pest resistance to the maximum degree so as to reduce the pesticide dosage, and is low in toxicity, safe to human and livestock and environmentally friendly.

The invention discloses a three-element compounding agent namely bensulfuron methyl.pretilachlor.pendimethalin for preventing and removing drought direct sowing rice field weeds. The three-element compounding agent is characterized by being prepared by taking bensulfuron methyl, pretilachlor and pendimethalin as active ingredients and then adding a safener namely fenclorim. The mixing ratio of bensulfuron methyl to pretilachlor to pendimethalin is (7.5-60):(75-600):(30-240) (ga.i. / ha), the ratio of pretilachlor to the safener namely fenclorim in the compounding agent is (3:1)-(3:2), the application time of the compounding agent is 3-5 days after sowing cultivated rice, the field recommended dosage is 337.5-562.5ga.i. / ha, and excess water should be avoided in 24 hours after application, otherwise, pesticide hazards are caused to the cultivated rice. The three-element compounding agent disclosed by the invention can be used for greatly expanding the weed control spectrum, reducing the number of application and the quantity of work, reducing the weeding cost, improving the economic benefit, reducing the pesticide hazards, improving the safety and relieving the drug resistance of weeds.

The invention belongs to the technical field of agricultural insecticide mixtures and in particular relates to an insecticide composition containing etrimfos and application thereof. The insecticide composition containing etrimfos comprises etrimfos and methacrifos active ingredients in a mass ratio of 2:(5-10), the effect can be obviously enhanced, the control effect is obvious, and the problem of pest resistance to insecticide at present is relieved to the utmost extent, so that the usage amount of pesticide is reduced, the control cost is reduced, and the influence on the environment is also relieved.

The invention belongs to the technical field of pesticide and insecticide compounding, and in particular, relates to a composition containing methoprene and an application thereof. The composition has the effective ingredients of methoprene and permethrin, wherein the mass ratio of the effective ingredient methoprene to the effective ingredient permethrin is 2 to (5-15); the composition can be obviously synergistic, has significant prevention and treatment effects, alleviates the conventional problem of pest drug resistance to a greatest extent, thereby reducing the dosage of pesticides and reducing prevention and treatment costs; and the composition is convenient to spray, has less pollution to the environment, and adapts to large-area farming ways.

The invention belongs to the technical field of agricultural fungicides, in particular to a bactericidal composition containing cyazofamid and an application thereof. The composition adopts the cyazofamid and another fungicide component B for complexing, the fungicide B is at least one selected from propamocarb, flumorph, cymoxanil, dimethomorph, fosetyl-aluminum, oxadixyl, metalaxyl, metalaxyl-M and chlorothalonil, the composition is used for controlling a variety of diseases caused by pathogenic fungi and particularly applicable to controlling downy mildew, blight, downy blight and the like of fruits, vegetables and a plurality of crops, and the composition has significant synergy and can better overcome and retard the drug resistance of pathogens.

The invention specifically relates to a water dispersible granule containing etrimfos and application thereof, belonging to the technical field of complex formulation of pesticides. The water dispersible granule comprises the following active components: etrimfos and crotoxyphos in a ratio of 1: 3-15. The water dispersible granule is an environment-friendly dosage form, has obvious synergistic effect and substantial prevention and treatment effect, greatly reduces the usage amount of pesticide and maximally alleviates the problem of pest resistance to insecticides in the prior art.

The invention belongs to the technical field of pesticide compounding, in particular to an emulsion in water of theta-cypermethrin and thiodicarb and application thereof. Effective components of the composition are theta-cypermethrin and thiodicarb, wherein the weight ratio of the theta-cypermethrin to the thiodicarb is 1: 5-1: 20. The compounded composition effectively resists the problem of resistance generation of injurious insects, and relieves the present problem of drug resistance of the injurious insects to the greatest extent, so that the dosage of pesticide is reduced, the influence to the environment is relieved, and the environmental protecting trend of the future society is accorded with; the composition of the invention obtains the optimal plant protecting effect.

The invention discloses a bupirimate.boscalid suspoemulsion and a preparation method thereof. The bupirimate.boscalid suspoemulsion is prepared from the following components in percentage by weight according to a formula: 5-20 percent of bupirimate and 5-20 percent of boscalid. According to the bupirimate.boscalid suspoemulsion and the preparation method disclosed by the invention, by compounding the bupirimate and the boscalid and adopting a reagent form of suspoemulsion, the two active ingredients have synergistic interaction, so that the sterilization treatment spectrum action is enlarged, the effect of controlling germs is remarkably improved, the drug resistance problem of the germs is relieved, the therapeutic effect on diseases including powdery mildew, botrytis cinerea, sclerotinia and various rot diseases of crops including rapes, grapes, fruit trees, vegetables and field crops is good, the dosage form is environmentally friendly, and pollution and damage to the environment are reduced.

The invention belongs to the technical field of pesticide compounding, and specifically relates to an emulsion in water containing isazofos and applications thereof. The effective components in the emulsion in water are high-efficient trans-cypermethrin and isazofos, wherein the weight ratio of isazofos to high-efficient trans-cypermethrin is in a range of 5:1 to 1:5. The compounding composition effectively solves the problem of generation of drug resistance of insects, maximally relieves the problem of drug resistance of insects, thus reduces the using amount of pesticide, reduces the pollution to the environment, is accord with the trends of green and environment-friendliness in the future society, and obtains an optimum crop protection effect.

The invention discloses bacillus with a boxthorn leaf blight preventing effect. The bacillus is antagonistic bacillus LKYLW-5 and belongs to bacillus atrophaeus, the length of a 16 S rDNA nucleotide sequence of the bacillus is 1492bp, the bacillus is preserved in China General Microbiological Culture Collection Center on November 29th 2018, and a preservation number is CGMCC NO.16837. The bacillusdisclosed by the invention is obtained from cultivated soil of a boxthorn planting area through slab confrontation culture screening; the bacillus can be applied to preventing and treating boxthorn leaf blight caused by alternaria alternata; the bacillus can inhibit mycelia growth of boxthorn leaf blight bacteria and germination of alternaria alternata spores; after boxthorn leaf blight pathogenic bacteria are inoculated to boxthorn plants, a preventing effect is 62.96%, and a treating effect is 60.15%; the bacillus has high-efficiency and obvious preventing and treating effects on the boxthorn leaf blight, is a biological prevention and control potential strain with high preventing efficiency and good environmental safety and has good development and application prospects.

The invention discloses a 2,5-disubstituted-1,3,4-oxadiazole derivative as shown in a general formula I which is described in the specification. In the formula I, R is halogen, hydrogen, a nitro group, a methyl group, a methoxy group or a trifluoromethyl group; R<1> is a methyl group, an ethyl group or hydrogen; R<2> is a trifluoromethyl group, chlorine or bromine; and R<4> is halogen or hydrogen. The compound has substantial inhibitory effect on armyworms and can be used an effective component of a pesticide.