The invention discloses a preparation method of bovine serum albumin-coated fenoxycarb nano-medicine for preventing and treating groove-orbital phenomenon. The process of wrapping fenoxycarb with bovine serum albumin for preventing and treating groove-orbital phenomenon adopts a physical embedding method. First, take a certain amount of bovine serum albumin (BSA) and dissolve it in double-distilled water to form an aqueous phase, and take a certain amount of fenoxycarb and dissolve it in acetonitrile to form an oil phase. Then, under the condition of high-speed stirring, the oil phase is added dropwise into the water phase, after emulsification for a period of time, it is cooled rapidly, ultrasonically pulverized to obtain a microemulsion, and cooled. Finally, freeze-dry to obtain fenoxycarb albumin nanoparticles. The new albumin nanoparticle preparation technology adopted in the method is to wrap the drug in the albumin without changing the albumin structure, which increases the drug loading and also has the effect of sustained release. The use of nanotechnology can reduce the amount, residue, cost and environmental pollution of chemical pesticides. At the same time, it can also improve the efficacy of pesticides, effectively increase the contact area between pesticides and target pests, and truly realize the high efficiency, low toxicity and safety of chemical pesticides.