The invention relates to an insecticide composition. The composition contains active ingredients and is characterized in that the active ingredients contain thiamethoxam and methidathion, wherein the weight ratio of thiamethoxam to methidathion is 1: (0.01-90). The invention further relates to an insecticide prepared from the insecticide composition. A dosage form of the insecticide is cream, water emulsion, micro-emulsion, water suspension, oil suspension, microcapsule suspension, wettable powder, water dispersible granule, soluble powder or soluble granule. The invention further relates to application of the insecticide in the prevention and control of one or more plant pests, such as scale insects, arrowhead scales, leafhoppers, thrips, aphid, white flies, mirid bugs, striped flea-beetles, leaf miners and spiny white flies. Compared with single-ingredient thiamethoxam or methidathion, the insecticide composition and the insecticide, disclosed by the invention, have a synergized action, and the prevention and control effect can be improved; due to non-single active ingredients, the insecticide resistance is difficult to produce; and multiple different species of pests occurring in a mixed manner can be prevented and controlled.