39results about How to "Improve pathological condition" patented technology

Disclosed is a substance delivery carrier for an extracellular-matrix-producing cell in the bone marrow, which comprises a retinoid. Also disclosed is an agent for treating myelofibrosis by utilizing a substance capable of regulating the activity or proliferation of an extracellular-matrix-producing cell in the bone marrow.

The invention discloses a strain of Lactobacillus plantarum LP1Z which produces lysozyme and efficiently antagonizes multidrug-resistant Helicobacter pylori and its application. Lactobacillus plantarum LP1Z, which was preserved in Guangdong Microbial Culture Collection Center on February 21, 2022, address: 5th Floor, Building 59, Compound, No. 100 Xianlie Middle Road, Guangzhou City, Guangdong Province, postcode: 510070, and the preservation number is GDMCC No :62256. (1) The probiotics involved in the present invention can produce various active antibacterial substances such as organic acid and lysozyme, and can effectively inhibit the growth of Helicobacter pylori in the stomach; Colonization, the body can compete with pathogenic bacteria for binding sites, effectively reducing the infection rate of Helicobacter pylori in the stomach; (3) It can improve the pathological state of the stomach and relieve inflammation. Therefore, Lactobacillus plantarum LP1Z has great application prospects in the preparation of products (such as medicines) for preventing or treating Hp infection, especially multidrug-resistant Hp infection.

The invention relates to a Chinese medicinal composition for treating fallopian tube obstruction and a preparation method thereof. The Chinese medicinal composition comprises Chinese angelica, Chinese honeylocust spine, ground beeltle, pangolin scales, beautiful sweetgum fruit, safflower, peach seed, dahurian patrinia herb, towel gourd vegetable sponge, bupleurum, earthworm, tangerine leaf, sanchi, raidx astragali, sanguisuge, immature bitter orange, centipede, diverse wormwood herb, heterophylly falsestarwort root and hiraute shiny bugleweed herb. The Chinese medicinal composition of the invention has reasonable compatibility and can be prepared into various oral preparations or external preparations clinically according to the Chinese medicinal common preparation method, and particularly has the advantages of quick absorption and high utilization degree of the crude drugs when being matched with rectal administration. Moreover, the medicament can promote blood and lymph circulation to accelerate by warming application to increase vascular permeability and improve the nutrition metabolism of tissues, promote the absorption of the inflammatory substances and achieve the effects onspasmolysis and antiphlogosis. Moreover, when being matched with the auricular therapy, the Chinese medicinal composition can adjust the function of the hypothalamic-hypophyscal-ovarian axis, improvethe pathological state and recover the normal reproduction physiology function.

The invention discloses a traditional Chinese medicine composition for treating hypertensive heart failure, belonging to the field of traditional Chinese medicines. The raw materials of the traditional Chinese medicine composition include Caulis Spatholobus, Panax notoginseng, Salvia miltiorrhiza, Radix Astragalus, and Citrus Red. The traditional Chinese medicine composition of the present invention conforms to the theory of modern systemic pharmacology, and the selected medicine has clear ingredients that can act on the disease targets of hypertension and heart failure at the same time; at the same time, it conforms to the traditional Chinese medicine syndrome differentiation theory system and the principle of compatibility of monarch, minister, assistant and envoy of Chinese medicine . Experimental results in vivo show that the Chinese medicine composition of the present invention can effectively reduce the systolic blood pressure of SHR in spontaneously hypertensive rats, and the effect is slightly lower than that of the positive control drug captopril; simultaneously, it can improve the ejection fraction and short-axis shortening rate of SHR heart , and the therapeutic effect is better than captopril. The traditional Chinese medicine composition of the invention has the advantages of less medicinal taste, reliable curative effect and clear main medicinal components, which can reduce non-drug efficacy factors in the traditional Chinese medicine compound preparation and improve the preparation level.

The invention relates to a new application of curcumadione combined with ginkgoic acid, in particular to the application of curcumadione combined with ginkgoic acid in preparing a drug for promoting bone formation. The combination of curedione and ginkgoic acid can significantly promote the differentiation of mesenchymal stem cells into osteoblasts and promote osteogenesis. The osteogenesis-promoting drug prepared with it as the active ingredient can promote the differentiation of mesenchymal stem cells into osteoblasts. Differentiate and promote the osteogenesis of osteoblasts, promote bone regeneration, and improve the pathological state of slow bone regeneration. As an effective treatment plan for fractures and osteoporosis, a new application has been developed for curcumadione combined with ginkgoic acid preparations, and it also provides new therapeutic drugs for patients with fractures and osteoporosis. Therapy offers new approaches.