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Traditional Chinese medicine composition for treating hypertensive heart failure

A technology of composition and traditional Chinese medicine, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of diverse ingredients, complex mechanism of action, ambiguity, etc., and achieve the effect of less medicinal taste, less non-drug effect factors, and clear effect

Active Publication Date: 2018-06-12
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, compound Chinese medicines often have diverse and complex ingredients and unclear mechanisms of action. Therefore, combining modern pharmacology and TCM syndrome differentiation system to seek compound Chinese medicines with definite curative effects is of great significance for the TCM treatment of hypertensive heart failure.

Method used

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  • Traditional Chinese medicine composition for treating hypertensive heart failure
  • Traditional Chinese medicine composition for treating hypertensive heart failure
  • Traditional Chinese medicine composition for treating hypertensive heart failure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A traditional Chinese medicine composition for treating hypertensive heart failure, which is made of the following crude drugs in parts by weight: 15 parts of Caulis Spatholobus, 5 parts of Sanqi, 10 parts of Salvia Miltiorrhiza, 15 parts of Astragalus, and 10 parts of Huajuhong. The decoction is prepared Methods as below:

[0047] 1) Take 15 parts of Caulis Spatholobus, 5 parts of Panax notoginseng, 10 parts of Salvia miltiorrhiza, 15 parts of Astragalus membranaceus, and 10 parts of Huajuhong, and crush them;

[0048] 2) Place in a round-bottomed flask, add 8 times the volume of 50% aqueous methanol solution of the traditional Chinese medicine composition, heat to reflux for 1 hour, and let cool;

[0049] 3) Put it in an ultrasonic water bath device again, the ultrasonic power is 600W, the frequency is 40KHz, the temperature is 50°C, the ultrasonic treatment is 60min, and let cool;

[0050] 4) Take the supernatant, centrifuge at 3000r / min for 15min, and filter to obt...

Embodiment 2

[0052] A traditional Chinese medicine composition for treating hypertensive heart failure, made of the following raw materials by weight: 18 parts of Caulis Spatholobus, 6 parts of Radix Notoginseng, 12 parts of Salvia Miltiorrhiza, 18 parts of Radix Astragali, 12 parts of Huajuhong, the decoction prepared Methods as below:

[0053] 1) Take 18 parts of Caulis Spatholobus, 6 parts of Panax notoginseng, 12 parts of Salvia miltiorrhiza, 18 parts of Astragalus membranaceus, and 12 parts of Huajuhong, and crush them;

[0054] 2) Place in a round-bottomed flask, add 6 times the volume of 50% aqueous methanol solution of the traditional Chinese medicine composition, heat to reflux for 1 hour, and let cool;

[0055] 3) Put it in an ultrasonic water bath device again, the ultrasonic power is 600W, the frequency is 40KHz, the temperature is 50°C, the ultrasonic treatment is 60min, and let cool;

[0056] 4) Take the supernatant, centrifuge at 3000r / min for 15min, and filter to obtain th...

Embodiment 3

[0058] A traditional Chinese medicine composition for treating hypertensive heart failure, which is made of the following raw materials in parts by weight: 12 parts of Caulis Spatholobus, 4 parts of Sanqi, 7 parts of Salvia Miltiorrhiza, 12 parts of Astragalus, and 7 parts of Huajuhong. The decoction is prepared Methods as below:

[0059] 1) Take the above-mentioned parts by weight of Caulis Spatholobus, Panax notoginseng, Salvia miltiorrhiza, Radix Astragali, and Huajuhong, and pulverize;

[0060] 2) Place in a round-bottomed flask, add 6 times the volume of 50% aqueous methanol solution of the traditional Chinese medicine composition, heat to reflux for 1 hour, and let cool;

[0061] 3) Put it in an ultrasonic water bath device again, the ultrasonic power is 600W, the frequency is 40KHz, the temperature is 50°C, the ultrasonic treatment is 60min, and let cool;

[0062] 4) Take the supernatant, centrifuge at 3000r / min for 15min, and filter to obtain the filtrate.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating hypertensive heart failure and belongs to the field of traditional Chinese medicine. Active pharmaceutical ingredients of the traditional Chinese medicine composition include caulis spatholobi, pseudo-ginseng, root of red-rooted salvia, radix astragali and exocarpium. The traditional Chinese medicine composition conforms to theories of modern systematic pharmacology, and selected medicine has clear ingredients and can act on disease targets of hypertension and heart failure at the same time; the composition also accords with conventional traditional Chinese medicine dialectical theory systems and monarch, minister, assistant and guide combination principles of traditional Chinese medicine. In-vivo experiment results show that the composition can effectively lower systolic pressure of spontaneously hypertensive rats SHR and is slightly less than positive control medicine captopril in effect; the compositioncan increase ejection fraction and shortening fraction of SHR hearts and is better than captopril in treatment effect. The composition is few in herbal medicine, accurate and reliable in treatment effect and clear in main medicinal ingredient, non-medicinal factors in traditional Chinese medicine compound preparations can be reduced, and preparation level is improved.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hypertensive heart failure. Background technique [0002] Hypertension is a common and frequently-occurring disease. The disease generally has a slow onset, and patients are often asymptomatic in the early stage, or only have symptoms such as dizziness, headache, palpitations, and tinnitus. If high blood pressure is poorly controlled for a long time, it can cause changes in the structure and function of the heart, which is called hypertensive heart disease, including: early left ventricular diastolic dysfunction, left ventricular hypertrophy, and gradual development of myocardial systolic dysfunction eventually leading to heart failure. Studies have shown that 70% of heart failure is caused by high blood pressure. Hypertensive heart failure is more common than heart failure caused by endocardial infection or arr...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61P9/12A61P9/04A61P9/00
CPCA61K36/258A61K36/481A61K36/486A61K36/537A61K36/752A61K2236/53A61K2236/333A61K2300/00A61K2236/00A61P9/00A61P9/04A61P9/12
Inventor 张国华陈凯黄裕刘馨庄宇鑫管怡晴党文振马韵词
Owner SOUTHERN MEDICAL UNIVERSITY
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