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Application of curcumadione combined with ginkgoic acid in the preparation of drugs for promoting bone formation

A technology of curedione and ginkgo, which is applied in the application field of curcumadione combined with ginkgoic acid in the preparation of drugs for promoting bone formation, to achieve the effects of improving pathological conditions, promoting bone regeneration, and promoting osteogenesis

Active Publication Date: 2021-10-29
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it has been reported that ginkgoic acid has a certain degree of anti-inflammatory effect, the application of curcumadione combined with ginkgoic acid as a bone-promoting drug is rarely reported.

Method used

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  • Application of curcumadione combined with ginkgoic acid in the preparation of drugs for promoting bone formation
  • Application of curcumadione combined with ginkgoic acid in the preparation of drugs for promoting bone formation
  • Application of curcumadione combined with ginkgoic acid in the preparation of drugs for promoting bone formation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] This embodiment provides a capsule of curdione combined with ginkgoic acid, the preparation method of which is: weigh 400 mg of curdione and 100 mg of ginkgoic acid, add 4000 mg of microcrystalline cellulose, 500 mg of sodium carboxymethyl starch, and 400 mg of dodecyl Alkyl sodium sulfate auxiliary materials are fully mixed, dry granulated by roller compaction method, mixed with an appropriate amount of magnesium stearate, filled into 3# hollow capsules, and made into capsules with a specification of 8 mg / capsule for oral use.

Embodiment 2

[0028] This example provides a tablet of curdione combined with ginkgoic acid, the preparation method of which is: weigh 400 mg of curdione and 100 mg of ginkgoic acid, add 2000 mg of starch, 150 mg of cross-linked PVP, and 400 mg of sodium carboxymethyl starch and mix Evenly, use 5% PVP and 75% ethanol solution as binder to prepare soft material, then granulate with 18 mesh sieve, dry at 65°C for 2 hours, add appropriate amount of talcum powder after granulation with 20 mesh, mix evenly, and press into tablets , made into a tablet with a specification of 12mg / tablet for oral use.

Embodiment 3

[0030] This embodiment provides a kind of curdione combined with ginkgoic acid injection, the preparation method of which is: weigh 800 mg curdione and 200 mg of ginkgoic acid, add 500 mg of sodium citrate, 1800 mg of sodium chloride, add 1000 ml of water for injection, Stir to dissolve, sterilize, filter, pot, and sterilize by circulating steam at 100°C for 15 minutes to make 2mg / 2ml injections for injection.

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Abstract

The invention relates to a new application of curcumadione combined with ginkgoic acid, in particular to the application of curcumadione combined with ginkgoic acid in preparing a drug for promoting bone formation. The combination of curedione and ginkgoic acid can significantly promote the differentiation of mesenchymal stem cells into osteoblasts and promote osteogenesis. The osteogenesis-promoting drug prepared with it as the active ingredient can promote the differentiation of mesenchymal stem cells into osteoblasts. Differentiate and promote the osteogenesis of osteoblasts, promote bone regeneration, and improve the pathological state of slow bone regeneration. As an effective treatment plan for fractures and osteoporosis, a new application has been developed for curcumadione combined with ginkgoic acid preparations, and it also provides new therapeutic drugs for patients with fractures and osteoporosis. Therapy offers new approaches.

Description

technical field [0001] The invention relates to a new application of curcumadione combined with ginkgoic acid, in particular to the application of curcumadione combined with ginkgoic acid in preparing a drug for promoting bone formation. Background technique [0002] Osteoporosis is a bone disease associated with aging, and its incidence increases with age. In 2016, the prevalence of osteoporosis among the elderly over 60 years old in China was 36%, of which 23% were males and 49% were females, which shows that osteoporosis has become an important public health problem facing our country. The most serious consequence of osteoporosis is osteoporotic fracture. Delayed union and nonunion of associated fractures have always been common orthopedic diseases, and their incidence can account for 5-10% of all fractures, which is also a difficulty in the treatment of orthopedic diseases. Non-surgical therapy mainly uses drugs to improve local blood circulation, promote bone regenera...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/60A61K31/122A61P19/10A61P19/08
CPCA61K31/122A61K31/60A61P19/08A61P19/10A61K2300/00
Inventor 张锦芳田楠楠
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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