The invention discloses a nickel-copper alloy with high strength and high corrosion resistance and a manufacturing method thereof. The method takes electrolytic copper and electrolytic nickel as major components, a small amount of manganese, iron, silicon, metal magnesium and metal titanium is added, and the impurity accounts for less than or equal to 0.5%. According to the invention, the components are sequentially put into a smelting furnace and subjected to the steps of smelting, stirring and slag extraction, refining, casting formation and the like to obtain a finished product of the nickel-copper alloy. Through the invention, the tensile strength is 670-720Rm / MPa, the elongation is 6-7.5, the strength is improved by 15% over the existing domestic nickel-copper alloy, and the corrosion resistance is improved by about twice. The nickel-copper alloy disclosed by the invention is widely applicable, has long service life and the like, can be used for producing plates, belts, pipes, rods, lines and forgings, and is applied to the industries such as shipbuilding, chemical industry, machinery manufacturing, aerospace, electronics and the like. The manufacturing method disclosed by the invention changes the original vacuum casting process, adopts a semi-continuous smelting method and reduces the production cost.