71results about How to "Good prospects for clinical application" patented technology

The invention relates to chemical crosslinking type glucan hydrogel and a preparation method thereof, and belongs to the technical field of biomedical functional polymer materials. The preparation method comprises the steps that glucan is dissolved in water at room temperature and then placed in an ice-water bath, and sodium periodate is added to obtain a mixed solution; the mixed solution is stirred for reaction for 2-6 h on the room temperature and dark conditions; the stirred solution is dialyzed with a regenerated cellulose dialysis bag in deionized water, and after dialysis is completed, freeze drying is performed to obtain partial hydroformylation glucan solids with the hydroformylation degree of 40-60 percent; the obtained partial hydroformylation glucan solids are dissolved in the deionized water to obtain an aqueous hydroformylation glucan solution, a multi-amino crosslinking agent is added in the aqueous hydroformylation glucan solution to be mixed evenly at the room temperature, and then the glucan hydrogel is prepared. The chemical crosslinking type glucan hydrogel is prepared by taking natural glucan macromolecules with the good biosafety as a material basis through chemical crosslinking of the partial hydroformylation glucan and the multi-amino crosslinking agent.

An oral liquid Xinshenghua is prepared from cane sugar, sorbic acid, polysorbate, and 7 Chinese-medicinal materials including Chinese angelica root, motherwort, Chuan-xiong rhizome, peach kernel, etc. Its preparing process is also disclosed.

The invention discloses an asiaticoside oral liquid and making method, which is made of total asiaticoside and corresponding auxiliary material. The invention has stable quality and obvious effect to be intaked safely and heathly, which improves the quality standard and enlarges the drug kinds to satisfy the need of the people for drugs.

The invention provides a nifuratel gel and the related preparation method. The invention is made of nifuratel as the raw material, a gel substrate carbomer and other relative auxiliary materials and used to cure vulvar and vaginal infections and vaginal mixed infections caused by germs, trichomonads and candidas. The invention has the advantages of obvious curative effect, relative stable quality, and is convenient to carry and take, and is safe and sanitary. The invention is comprehensively improved in quality, and enriches the medication varieties after the formulation is changed, thus the invention has great significance for further meeting and guaranteeing the medication requirements of people.

The invention discloses a full-degradable metal-based closure clamp. The full-degradable metal-based closure clamp is applicable to closing blood vessels or tubular tissues in an endoscope operation.The full-degradable metal-based closure clamp has the following advantages that the closure clamp is made of degradable pure magnesium or magnesium alloy; the closure clamp is of a V-shaped structure,and an upper arm and a lower arm of the closure clamp are connected through an arc tail for removing stress concentration; the head of the upper arm and the head of the lower arm of the closure clampare provided with closing-locking structures which achieve the closing effect; the head and shoulder of the upper arm and the head and shoulder of the lower arm of the closure clamp are provided withclamping structures which are matched with clamp-application pincers; clamping teeth which can be cooperatively closed are arranged on a clamping surface of the closure clamp body. When the clamp-application pincers clamp and close the closure clamp, the upper arm elastic structure of the closure clamp is in contact with the lower arm structure to form closure, and the matched clamping teeth on the clamping surface are closely attached to blood vessels/tissues to make the lumens closed. Due to the closure mode of the closure clamp for the blood vessels/tissues and the degradability and mechanical properties endowed by magnesium-based materials, the closing capability is high, the clamp does not easily shed, body fluid is completely degraded, and clinic requirements can be well met.

The invention relates to the field of biotechnology, and in particular relates to an aptamer capable of simultaneously identifying OdDHL ([N-(3-oxododecanoyl)-L-homoserine lactone]) and BHL (N-butanoyl-L-homoserine lactone) and an application thereof. OdDHL and BHL are signaling molecules of las and rhl signaling pathways of a pseudomonas aeruginosa population effect system, respectively; and the activation of the two signaling pathways is capable of starting expression of a pseudomonas aeruginosa virulence gene. An aptamer bonding OdDHL and BHL in high affinity is screened by using a competition method. The aptamer has a population effect system for interfering pseudomonas aeruginosa and the potential for inhibiting the expression of the pseudomonas aeruginosa virulence gene. The affinity of bonding the aptamer with OdDHL and BHL is equivalent to that of an antibody, and the preparation process is simple and easy to operate and low in cost.

Use of Fructus schisandrae in preparation of medicaments for preventing and reducing toxicity and side effects of antineoplastic agents. The toxicity and side effects of antineoplastic agents are cardiovascular toxicity, hepatotoxicity, nephrotoxicity, suppression of bone marrow, immunosuppression, or alopecia etc induced by antineoplastic agents. Fructus schisandrae and extracts thereof, especially ethanol extracts, schisandrin B, are effective in reducing antineoplastic agent's toxicity and side effects.

The invention discloses injectable temperature-sensitive hydrogel for cartilage regeneration and repair and a preparation method of the injectable temperature-sensitive hydrogel. The injectable temperature-sensitive hydrogel is prepared from the following components: 1-10g/100ml of a chitosan solution, 0.5-15g/100ml of a sodium glycerophosphate solution, 4-15g/100ml of a collagen solution and 2-10 parts of decalcified bone matrix powder. The injectable temperature-sensitive hydrogel for cartilage regeneration and repair has a temperature-sensitive characteristic, the sol can be implanted into an organ or a defect part in a body through an injector or an endoscope, so that the gel is quickly formed in situ, and the effect of the gel is exerted.

The invention provides a ketoconazole gel and a preparation method thereof. The ketoconazole gel is used for treating vulval and vaginal infection and vaginal mixed infection which are caused by bacteria, trichomonad and candida albicans. The ketoconazole gel mainly consists of ketoconazole, hydroxypropyl-beta-cyclodextrin, carbomer, chitosan and poloxamer, improves stability of the ketoconazole and quanlity, does not cause drug resistance phenomena, and is high in safety and suitable for treatment of vaginal infection of women in the gestation period. The ketoconazole gel is characterized by having temperature susceptibility and biological adhesion and slowly performing long-acting release so that the ketoconazole gel has the advantages of facilitating use of patients and being high in patient compliance, convenient to take, safe, hygienic and the like. The quality standard is improved comprehensively, pharmacy variety is enriched after dosage form is changed, and the ketoconazole gel and the preparation method have great significant meaning for further meeting and guaranteeing pharmacy requirements of users.

The invention discloses a codon-optimized Chi3L1 gene. The nucleotide sequence of the gene is shown in SEQ ID NO.1. The invention further discloses a method for expressing and purifying Chi3L1 protein through the Chi3L1 gene. The method for obtaining Chi3L1 recombinant protein is provided and is low in cost and easy and convenient to implement, the Chi3L1 recombinant protein has very strong immunity activity and a function of promoting growth of tumors, can be taken as an active drug for immunity research and a drug target for development of anti-tumor drugs and has a good foundation and clinical application prospect.