77 results about "Nitrosourea" patented technology

The present invention relates to an anticancer medicine composition and belongs to the field of medicine technology. The anticancer medicine composition contains topomerase inhibitor and medicinal supplementary material. The topomerase inhibitorcan inhibit intracellular DNA repair function and reduce the tolerance one tumor cell on anticancer nitrosourea medicine; and the medicine supplementary material is mainly degradable biocompatible polymer. During the degrading and absorption process of the supplementary material, the anticancer medicine is released slowly to the tumor part, and this can lower the systemic toxic reaction while maintaining local effective medicine concentration. The anticancer medicine composition contains also anticancer nitrosourea medicine, and is set to the tumor part locally to enhance the treatment effect.

The invention relates to novel chloroethyl nitrosourea with anticancer activity and a synthesizing method thereof. The chloroethyl nitrosourea is a compound with a structure of the general formula (I), wherein n is an integer of 2 to 6. The chloroethyl nitrosourea can be used for treating gliomatosis cerebri, colon cancer and leukemia; compared with the existing nitrosourea-type anticancer medicine, the drug resistance is lower, the chemical therapy effect is better, the preparation method is simple in operation, the reaction yield is high, the toxicity is small, the cost is low, the method is suitable for the industrialized production, the development prospect is wide, and the application value is good.

The invention relates to novel beta-chloroethylnitrosourea compounds, and a synthesis method and application thereof. The structure of the beta-chloroethylnitrosourea compounds is disclosed as general formula (II). The in-vitro antitumor screening test on the compounds disclosed as general formula II proves that the compounds disclosed as general formula I have obvious inhibiting action on human cerebral nerve glioma cells SF763, SF767, SF126 and SF188, human colon cancer cell HT29, mouse leukaemia cell L1210 and many other tumor cell lines and have higher tumor inhibiting activity than the existing CENU and CENU/O6-benzylguanine combined medicine.

The invention provides a wheat anther differentiation culture medium formula. The culture medium formula proportionally comprises KNO3, C8H7O2K, (NH4)2SO4, KH2PO4, CaCl2, MgSO4, Na2-EDTA, FeSO4.7H2O, MnSO4.4H2O, ZnSO4.7H2O, H3BO3, KI, CuSO4.5H2O, Na2Mo4.2H2O, CoCl2.6H2O, glycine, folic acid, methyl-nitrosourea, alanine, lysine, vitamin B1, vitamin B6, 3-picolinic acid, sucrose, gelling agent, NAA, KT, prohexadione calcium, sorbitol, protein hydrolysate, colchicine and biotin. The culture medium has the advantages of efficiently improving the differentiation rate of the wheat anther callus seedlings and reducing the ablation rate, and the wheat anther culture efficiency can be obviously improved.

The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor platinum coordination complexes, antimetabolites, mitotic inhibitors, anticancer antibiotics, topoisomerase I and/or II inhibitors, proteasome inhibitors, histone deacetylase inhibitors, nitrogen mustard alkylating agents, nitrosourea alkylating agents, nonclassical alkylating agents, estrogen antagonists, androgen antagonists, mTOR inhibitors, tyrosine kinase inhibitors, and other agents selected from aplidine, ET-743, PM02734 and PM00104, and the use of these combinations in the treatment of cancer.

The invention provides a free microspore induced culture medium for brassica campestris. A formula of the culture medium contains KNO3, MgSO4.7H2O, KH2PO4, Ca(NO3)2.4H2O, Na2-EDTA, FeSO4.7H2O, MnSO4.4H2O, AgNO3, H3BO3, ZnSO4.7H2O, KI, Na2MoO4.2H2O, CuSO4 .5H2O, CoCl2.6H2O, chlorinated 2-hydroxyethyl trimethylamine, L-glutamine, vitamin B1, vitamin B6, nicotinic acid, folic acid, biotin, inositol, glycine, L-glutathione, methyl nitrosourea, sucrose, phytagel, 6-BA, NAA, polyethylene glycol, protein hydrolysate, active carbon and phytosulfokine PSK-alpha. The culture medium can be used for greatly improving the induction efficiency of free microspore embryogenic calli of brassica campestris, and has an important application value.

The invention discloses a solid tumor resisting medicine composition with arctigenin and nitrosourea alkylating agent anti-tumor medicines as active components. The weight ratio of arctigenin to nitrosourea alkylating agent anti-tumor medicines is 1:0.001-1000, and preferably 1:0.01-600. The anti-tumor medicine composition provided by the invention is advantaged in clear components, wide anti-tumor spectrum, substantial treatment effect against various tumors, low price, low side-effects, and good clinical application prospect.

The invention discloses a bicyclo[4.1.0]heptane nitrosourea derivative for a biological orthogonal reaction, and a preparation method and an application thereof. The structural formula of the bicyclo[4.1.0]heptane nitrosourea derivative is represented by formula I; and in the formula I, R represents an alkyl group with the carbon atom number of 1-15, an aryl group with the carbon atom number of 6-15 or H, X represents O or N, and n is a natural number between 1 and 10. A pH-initiated IEDDA reaction of trans-cycloheptene and tetrazine is provided for the first time, and can be used as a biological orthogonal reaction. A bicyclonitrosourea derivative (BNU)-bicyclo[4.1.0]heptane nitrosourea derivative is introduced as a precursor for storing and releasing trans-cycloheptene, so that the highactivity of the trans-cycloheptene is utilized, and the instability of the trans-cycloheptene is avoided as much as possible. The pH-initiated biological orthogonal reaction can be applied to in-vitroprotein labeling, living cell imaging and tissue pre-labeling imaging, and can also be applied to living animal tumor pre-labeling imaging. The novel biological orthogonal reaction has a wide application prospect.

An anticancer composition carrying melphalan and carmustine is a sustained release injection which consists of sustained release microspheres and a dissolvent, wherein, the sustained release microspheres comprise an anticancer active component and a sustained release adjuvant, and the dissolvent is a common dissolvent or a special dissolvent containing a suspending agent. The suspending agent has the viscosity of 100cp-3000cp (at the temperature of 20-30 DEG C) and is selected from sodium carboxymethyl cellulose and the like; the anticancer active component is a combination of a nitrosourea drug and an alkylating agent selected from the melphalan, ifosfamide, 4H-peroxycyclophosphamide or norcantharidin; the sustained release adjuvant is selected from copolymer of polyphosphate esters such as p(LAEG-EOP), p(DAPG-EOP) and the like, copolymer of the polyphosphate ester and polylactic acid, polifeprosan, dienoic fatty acid and sebacic acid, or copolymer or polyblend of poly(erucic acid dimmer-sebacic acid) or poly(fumaric acid-sebacic acid); the anticancer composition is also made into a sustained release implant, and injected into or placed inside or at the periphery of tumor to keep the effective drug concentration more than 60 days. The anticancer composition can also obviously reduce the general reaction of the drug, and selectively enhance the curative effects of non-operative therapies such as radiotherapy, chemotherapy and the like.

The invention relates to the field of biotechnology and particularly relates to a composition and its preparation method and application. The composition comprises cruciferous vegetable lyophilized powder, pumpkin lyophilized powder and konjac gum. The pharmaceutical composition for observably preventing and treating gastric cancer and colon cancer can prevent and treat rat ulcerative gastric cancer induced by an acetic acid solution with acetic acid content of 30% and methyl-nitro-nitrosoguanidine (MNNG) and can also prevent and reduce rat colon cancer induced by N-methyl-N-nitrosourea (MNU).

An anticancer in vivo implant applied locally is prepared from the anticancer nitrosourea-type medicine, the anticancer synergist chosen from bichloroethanamine-type alkylating agent, anticancer antibiotic, and hormone-type anticancer medicine, and the biocompatible and biodegradable high-molecular polymer as medicinal additive.

The invention discloses a tumor-targeting drug-resistant O6-thiophenemethyl guanine-indolequinone-chloroethyl nitrosourea combined molecule and a preparation method thereof, and relates to the field of pharmacy. According to the compound, indolequinone serves as a hypoxia activation pharmacophore, and under the tumor hypoxia condition, indolequinone is reduced to generate an imine substance with cytotoxicity; the CENUs pharmacophore is decomposed to generate chloroethyl carbocations, so that DNA interstrand cross-linking is caused; and meanwhile, an AGT inhibitor O6-TMG derivative is released, and an AGT inhibition effect is achieved. Therefore, the compound disclosed by the invention not only can play a dual anti-tumor effect, but also has drug resistance and tumor hypoxia targeting property, and has high-efficiency and low-toxicity anti-cancer activity.