Anticarcinogenic internal implant agent

A technology of implants and anticancer drugs, applied in the field of medicine, can solve problems such as difficult treatment, treatment failure, and enhanced drug tolerance

Inactive Publication Date: 2005-10-12
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, further studies have found that DNA repair and other self-protective functions in many tumor cells are significantly increased after chemotherapy drug treatment, which in turn manifests as increased resistance to the drugs used
The latter often leads to increased resistance of tumor cells to other anticancer drugs, resulting in more difficult treatment and ultimately treatment failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Put 80 mg of polyglycolic acid and glycolic acid copolymer (PLGA) with a molecular weight of 10,000 into a container, add a certain amount of organic solvent to dissolve and mix well, add 10 mg of carmustine and 10 mg of oxaliplatin, and re-shake After homogenization, the organic solvent was removed by vacuum drying. The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain an anticancer in vivo implant containing 10% carmustine and 10% oxaliplatin. All are percentages by weight.

Embodiment 2

[0078] According to the method described in Example 1, the anti-cancer in vivo implant is made, but the difference is that the contained anti-cancer active ingredients are:

[0079] (a) 1-35% of orestamustine, streptozocin, amustine, amustine, nimustine, bendamustine, dithiomustine, bofuramustine , carmustine, emustine, ecomustine, dithiamustine, garmustine, formustine, estramustine, comustine, nemustine, mannolimus Lomustine, lomustine, methyllomustine, semustine, ramustine, prednimustine, uramustine, samustine, tauramustine, tamustine Or Spiromustine with 1-35% of cisplatin, carboplatin, heptaplatin, denaplatin, enloplatin, cyclothioplatin, cisspiroplatin, dextromethopretin, isoproplatin, lobaplatin, miplatin, A combination of nedaplatin, omaplatin, oxaliplatin, spiroplatin, spiroplatin, or zeniplatin; or

[0080] (b) 1-35% of orestamustine, streptozocin, amustine, amustine, nimustine, bendamustine, dithiomustine, bofuramustine , carmustine, emustine, ecomustine, dithiamu...

Embodiment 3

[0084]Put 80 mg of ethylene vinyl acetate copolymer (EVAc) into a container, add 100 ml of dichloromethane, dissolve and mix well, add 10 mg of nimustine and 10 mg of vinblastine, re-shake, and then vacuum dry to remove organic matter. solvent. The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain an anti-cancer in vivo implant containing 10% of nimustine and 10% of vinblastine. All are percentages by weight.

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PUM

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Abstract

An anticancer in vivo implant applied locally is prepared from the anticancer nitrosourea-type medicine, the anticancer synergist chosen from Pt compound, anticancer taxol, medicine and vegetative alkaloid, and the biocompatible and biodegradable high-molecular polymer as medicinal additive.

Description

(1) Technical field [0001] The invention relates to an anticancer implant in vivo, belonging to the technical field of medicines. (2) Background technology [0002] The treatment of solid tumors mainly includes surgery, radiotherapy and chemotherapy. Among the various treatments used, chemotherapy is relatively safe and reliable, and has been widely used in many malignant tumors. Among them, the more commonly used chemotherapeutic drugs are nitrosourea anticancer drugs. However, further studies have found that DNA repair and other self-protection functions in many tumor cells are significantly increased after chemotherapy drug treatment, which in turn manifests as increased resistance to the drugs used. The latter often leads to increased resistance of tumor cells to other anticancer drugs, resulting in more difficult treatment and ultimately treatment failure. [0003] It has recently been found that combined chemotherapy can inactivate or inhibit the function of DNA rep...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/17A61K45/06A61P35/00
Inventor 孔庆忠孙娟于建江孙宪德
Owner DASEN BIOLOGICAL PHARMA CO LTD
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