136 results about "Plant Alkaloids" patented technology

The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and / or eliminating fine lines and / or wrinkles of skin, wherein the compositions include limonoid constituents which inhibit acetylcholine release at neuromuscular junctions of skeletal muscle so as to relax the muscles involved with wrinkling, folding and creasing of skin, e.g., facial movement and expression. The limonoids preferably include the plant alkaloids toosendanin and azadirachtin. The compositions, which also are used to treat hyperhidrosis, are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

The invention belongs to the technical field of bio-organic fertilizer, and particularly discloses chicken manure fermented fertilizer, which is prepared through normal temperature fermenting, three-time mixing and separating adding of dry chicken manure, rice bran powder, flue curing straw, EM (Effective Microorganisms), basalt powder and camellia shell powder, and has the benefits that the nutrient in the agricultural waste is utilizes, so as to avoid environmental protection; the plant alkaloid and the perfume oil in the flue curing straw and the camellia shell powder are utilized to kill the pest in the field; the EM can produce microorganisms beneficial to the growth of organisms, so as to accelerate the fertility releasing and the crop growth; and the basalt powder can provide the rich elements necessary for the crop as calcium, magnesium, sulfur, iron, copper, zinc and cobalt. Through practice, the chicken manure fermented fertilizer is applicable to all sorts of food crop and fruit and vegetables, enables the soil fertilizer efficiency to last 4 months with one-time fertilization, and enables the average increase of the crop to be 15%, as a result, not only is the labor intensity during agricultural production reduced, but also the soil ecological balance can be adjusted and the soil permeability is improved as well.

A composite medicine for treating solid tumor by locally putting it in the tumor is composed of the active anticancer component (plant alkaloid and its symergist chosen from taxol-type anticancer medicine, antineoplastic antibiotic and antimetabolitic), and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).

The invention discloses an environment-friendly coating which comprises the following components by weight parts: 25-30 parts of water, 1-2 parts of plant alkaloid, 1-3 parts of a wetting agent, 2-4 parts of a dispersant, 2-4 parts of a de-foaming agent, 15-25 parts of titanium dioxide, 20-30 parts of diatomite, 10-15 parts of talcum powder, 15-20 parts of an acrylic emulsion, 1-2 parts of a mildew-proof agent, 2-4 parts of a fireproof agent and 1-2 parts of an anticorrosive antibacterial agent. The coating is reasonable in composition, low in cost, good in compatibility among the components, environment-friendly, mildew-proof, antibacterial, anticorrosive, insect-proof and flame-retardant, and has excellent application values; harmful substances such as formaldehyde emitted by furniture and the like can be absorbed; a natural antibacterial agent and an inorganic antibacterial agent are mixed for use, so that the stable performance of the coating is ensured; the film-forming drying time is short, the hardness is good, and the extensibility and the heat resistance are very good.

The invention relates to filter tip addition material capable of selectively reducing the release amount of hydrocyanic acid in cigarette mainstream smoke and a preparation method thereof, new material which can effectively adsorb acidic gas can be obtained by loading plant alkaloids onto activated carbon fiber, the alkaloids are extracted from one or multiple Chinese herbal medicines of golden thread, amur corktree bark, root of Anhwei barberry and leatherleaf mahonia leaf and have anti-bacterial and anti-tumor activity, the extracted alkaloids are dissolved in 0.01%-0.1% of sodium hydroxidesolution and loaded on the activated carbon fiber by heating and stirring, then water washing and drying are further performed, and modified activated carbon fiber material containing basic groups isfinally obtained. The material is added into cigarette filter sticks and can reduce the content of the hydrocyanic acid in the cigarette mainstream smoke by more than 25%, and reduce the tar content by more than 25%, and an alkaloid additive has the characteristics of high boiling point, no smell, safety in administration and the like; simultaneously, as the selected activated carbon fiber material can stably adhere the alkaloids, the adverse effects to the organoleptic quality of cigarettes can be avoided, and the purposes of reducing harm and reducing tar can be further achieved.

The invention relates to a method for determining the blending proportion of expanded cut stem in cut tobacco. The method comprises the following steps of: a, manually blending the expanded cut stem with other components of the cut tobacco according to a preset blending proportion and recording the proportional value; b, balancing the blended cut tobacco; c, determining the total plant alkaloid content of the balanced cut tobacco by utilizing a flow analyser; d, fitting according to the value of the total plant alkaloid content and the recorded blending proportional ratio value to obtain an expanded cut stem blending proportion predicting model; e, balancing the cut tobacco in formula content the expanded cut stem blending proportion of which is required to be determined in the actual process; f, determining the total plant alkaloid content of the balanced cut tobacco by utilizing the flow analyser; and g, calculating the expanded cut stem blending proportion of the cut tobacco in formula content in the actual process. By applying the invention, technical parameters can be provided for correctly controlling the blending proportion of the cut stem in the cut tobacco in formula content, and support can be provided for stabilizing the physical quality and sensory quality of cigarette products.

The invention relates to an anti-cancer sustained release injection containing epothilone derivative, consisting of sustained microspheres and menstruum. The sustained microspheres comprise anti-cancer drugs selected from taxane, alkylating agent and / or plant alkaloid and the like, the epothilone derivative and sustained release auxiliary material. The menstruum is a special menstruum containing suspending agent. The epothilone derivative is selected from epothilone B, epothilone D, iso-epothilone D, BMS-247550, azaepothilone B, furan epothilone D or BMS-310705. The sustained release auxiliary material is selected from poly-dl-lactide, the glycolic acid copolymer of the poly-dl-lactide, polyethyleneglycol, the polylactide copolymer of the polyethyleneglycol, carboxyl terminated polylactide copolymer, fatty acid and decanedioic acid copolymer, etc. The suspending agent is selected from carboxymethyl cellulose and the like with the viscosity of 100cp to 3000cp (under the temperature of 25 DEG C to 30 DEG C). The sustained release microsphere can also be made into a sustained release implant. The sustained release injection is injected or arranged in or around the tumour and can release drug at partial position for 40 days approximately, therefore, the sustained release injection improves the local drug concentration selectively and enhances the treatment effect of non-operative treatments, such as radiotherapy, chemotherapy and the like at the same time.

Disclosed is an anti-cancer slow release injection containing Epothilone derivatives which comprises slow release microspheres and dissolvent, the slow release micro-balloons include anticancer drugs selected from Paclitaxel, alkyl agent and / or plant alkaloids, Epothilone derivatives and slow release auxiliary materials, the dissolvent being specific dissolvent containing suspension adjuvant. The Epothilone derivatives are selected from Epothilone B, Epothilone D, Isoepothilone D, BMS-247550, azaepothilone B, furaepothilone D or BMS-310705. The slow release auxiliary material is selected from poly-D, L-lactic acid and its glycolic copolymer, polyethylene glycol and polylactic acid copolymer, PLA-COOH copolymer, aliphatic acid and sebacylic acid copolymer, the viscosity of the suspension adjuvant is 100-3000cp (at 25-30 deg C), and is selected from sodium carboxymethylcellulose, The slow release microspheres can also be prepared into slow release implanting agent, for injection or placement in or around tumor with the period of local drug release can be about 40-50 days, as a result, the local medicinal concentration can be increased selectively, and the treatment effect of the non-operative treatment methods such as chemotherapy can be improved substancially.

The invention relates to an anti-cancer sustained release injection containing epothilone derivative, consisting of sustained microspheres and menstruum. The sustained microspheres comprise anti-cancer drugs selected from taxane, alkylating agent and / or plant alkaloid and the like, the epothilone derivative and sustained release auxiliary material. The menstruum is a special menstruum containing suspending agent. The epothilone derivative is selected from epothilone B, epothilone D, iso-epothilone D, BMS-247550, azaepothilone B, furan epothilone D or BMS-310705. The sustained release auxiliary material is selected from poly-dl-lactide, the glycolic acid copolymer of the poly-dl-lactide, polyethyleneglycol, the polylactide copolymer of the polyethyleneglycol, carboxyl terminated polylactide copolymer, fatty acid and decanedioic acid copolymer, etc. The suspending agent is selected from carboxymethyl cellulose and the like with the viscosity of 100cp to 3000cp (under the temperature of 25 DEG C to 30 DEG C). The sustained release microsphere can also be made into a sustained release implant. The sustained release injection is injected or arranged in or around the tumour and can release drug at partial position for 40 days approximately, therefore, the sustained release injection improves the local drug concentration selectively and enhances the treatment effect of non-operative treatments, such as radiotherapy, chemotherapy and the like at the same time.

The invention belongs to the technical field of tobacco processing, and concretely relates to a method online for detecting and evaluating the online cut tobacco mixing uniformity of cigarette. A principle that the sugar / nicotine ratio of online cut tobacco of the cigarette can well reflect the intrinsic quality of the tobacco is used to establish a method for evaluating the online uniformity by using the difference of the online sugar / nicotine ratio of the cut tobacco. The method mainly comprises the following steps: preparing a model sample; determining the respective content of total plant alkaloids and total sugars in the sample by using a continuous flow technology; establishing a model for predicating the content of the total plant alkaloids (total sugars) in the cut tobacco sample; and predicating the content of the total plant alkaloids (total sugars) after the uniform mixing of the online cut tobacco according to the model, and evaluating the mixing uniformity of the cut tobacco according to the predicated content. The method can accurately realize online and real-time monitoring and evaluation of the uniformity of the mixed cut tobacco in order to lay a foundation for the stability of the quality of the cigarette; and the method can provide reference for the improvement of relevant processes and the fine control of cigarette production, so the method has good practical values and promotion and application meaning.

The invention relates to an agricultural composition containing flubendiamide and plant-derived substances, and belongs to the field of plant protection, wherein the plant-derived substances are active components of one or a plurality of materials selected from plant alkaloids, plant terpenes, plant flavones and plant light-activated toxins, a mass part ratio of A to B is 30:1-1:30, and the composition has significant plant diseases and insect pest prevention effects on crops.

The method discloses a method for improving tobacco leaf quality on an upper part of flue-cured tobacco by applying steam explosion technology, and relates to the technical field of tobacco processing. The method comprises the following steps of: performing steam explosion on the upper tobacco leaf of flue-cured tobacco, wherein the working medium for steam explosion is saturated steam, the steam explosion time is less than 0.01 second, the steam pressure is between 0.4 and 0.8 MPa, and the pressure preserving time is between 10 and 60 seconds; drying the upper tobacco leaf subjected to steam explosion, and reducing the moisture to 10-25 percent; and making the dried upper tobacco leaf enter a shredding and expanding process, and using the upper tobacco leaf in a cigarette formula. The method for improving the tobacco leaf quality effectively reduces the total plant alkaloid content in the tobacco leaf on the upper part of flue-cured tobacco, increases the content of reducing sugar, lightens the irritation and strength of the upper tobacco leaf, increases the aroma, effectively improves the combustibility of the tobacco leaf, makes the ratio of the upper tobacco leaf of the flue-cured tobacco to the cigarette formula increased from 10 percent to 15 percent, and effectively improves the utilization rate of the tobacco leaf on the upper part.

The invention discloses a fuming membrane material for a heating mode and a preparation method thereof and relates to a cigarette fuming material. The fuming membrane material for the heating mode isprepared from multiple raw materials including a supporting material, a flavoring module, a slow release module, a taste module, a strength module, a fuming module and a membrane formation module. Theflavoring module is made from a tobacco extract, the slow release module is a porous support, the taste module contains one or more plants homological in medicine and food, the strength module is made from a plant alkaloid or a derivative of plant alkaloid, and the fuming module is made from sugar alcohol. The preparation method of the fuming membrane material for the heating mode is simple, convenient and easy to achieve, a membrane structure produces phase change under the heating condition and by controlling a mixing sequence, mixing temperature, membrane formation temperature and other conditions, the slow release material uniformly release flavoring substances, the substances enter the oral cavity of a consumer with the alkaloid and smoke, physiological and mental satisfactions are met.

The invention discloses a pig manure fermented fertilizer belonging to the technical field of bio-organic fertilizers. The pig manure fermented fertilizer is prepared from dry pig manure, a Gymboree leavening agent, corn flour, flue-cured tobacco stalks, sawdust, spent mushroom composts, an EM stock solution, basalt powder and tea shell powder through the steps of normal-temperature fermentation, three-time stirring and in-batch addition. The pig manure fermented fertilizer has the beneficial effects that nutrients in agricultural wastes are utilized, and environment pollution is also avoided; meanwhile, pests in soil can also be killed by plant alkaloids and aromatic oil contained in the flue-cured tobacco stalks and the tea shell powder; the EM stock solution can produce microorganisms beneficial to the biological growth and promote fertility release and crop growth; the basalt powder can provide the soil with abundant calcium, magnesium, sulfur, iron, copper, zinc, cobalt and other elements necessary for crops; practices prove that the pig manure fermented fertilizer is suitable for various kinds of crops and can ensure that the soil fertilizer efficiency lasts for 4 months and the yield of the crops is averagely increased by 14% through disposable fertilizer application, not only is the labor intensity in agricultural production reduced, but also the ecological balance of soil can be reduced, and the permeability of the soil can be improved.

A tobacco leaf chemistry routine index weight assignment method for tobacco leaf quality evaluation is provided; after a tobacco leaf sample is taken and prepared, totally 14 indexes comprising total plant alkaloids, total nitrogen, total sugar, reducing sugar, potassium ion, chlorine ion, starch, petroleum ether extract total amount, volatile alkalis, pH value, nitrogen-nicotine ratio, proteins, sugar-nicotine ratio and Shmuck value are determined as routine chemical component indexes; then detection or calculating methods of the indexes are determined; and finally a statistical method is determined. Basic principles of correlation analysis and principal component analysis are used for reference, and based on the tobacco leaf routine chemical component indexes, correlation alternative and factor analysis weight assignment are adopted to achieve dimension reduction of multidimensional data and accurate assignment of the characteristic indexes. The method has the advantages of higher practicability, simple and accurate operation, and easy promotion and application.

The invention provides a method and product for acquiring plant alkaloid and an aroma substance in coffee or tea by heating suction. The product comprises a raw material core and a heating device; theraw material core is formed by machining the coffee or the tea used as a main raw material; and the heating device mainly comprises a power supply, a controller, a heating cavity and a shell. When the product is in use, the raw material chip is placed into the heating cavity, the controller controls the power supply to supply power to the heating cavity, the heating cavity heats the raw materialcavity, the plant alkaloid such as caffeine and the like, the aroma substance and an atomizing agent are separated from the raw material chip due to heating so as to form steam fog together, and the steam fog is directly sucked into the mouth of a user in a suction mode so as to achieve a refreshing effect and generate pleasant satisfaction. Compared to a conventional method for drinking by brewing and the like, the method and product for acquiring the plant alkaloid and the aroma substance in the coffee or the tea by heating suction, which are provided by the invention, have the characteristics of no limitation to brewing utensils, simple acquisition mode, repeated use, aromatic flavor, good refreshing effect and the like, and have good application prospect.

A slow-release anticancer medicine in the form of injection or implant is disclosed. Said slow-release injection is composed of a special solvent containing suspending aid and the slow-release microballs consisting anticance medicine, iterstitial hydrolyte and slow-releasing auxiliary. Said anticancer medicine is chosen from taxane, alkalating angent and vegetative alkaloide. Said interstitial hydrolyte is chosen from collagenase, relaxin, etc. Said slow-releasing auxiliary is chosen from polylactic acid copolymer, EVAc, polyethanediol, etc.

An anticancer in vivo implant applied locally is prepared from the anticancer nitrosourea-type medicine, the anticancer synergist chosen from Pt compound, anticancer taxol, medicine and vegetative alkaloid, and the biocompatible and biodegradable high-molecular polymer as medicinal additive.

The invention provides a method for recycling plant alkaloid from smokeless tobacco extract. The method is characterized by comprising the following steps that: a pH regulator is added into the smokeless tobacco extract to form alkaline mixed liquor, so that the plant alkaloid in the smokeless tobacco extract is protonated; the alkaline mixed liquor is concentrated, and then extracted and concentrated again to obtain free plant alkali liquor, wherein the free plant alkaloid content of the free plant alkali liquor reaches 90% or above, and the nicotine content of the free plant alkali liquor reaches 80% or above; the free plant alkali liquor is separated by further combining a molecular distillation method, so that nicotine in the free plant alkali liquor can be recycled, and the recovery rate of the nicotine reaches 90% or above; as the extracted free plant alkali liquor and the recycled nicotine are protonated products, the taste is good, the strength is stronger, however, the irritation to the larynx is weaker; through the method, tobacco waste can be recycled, so that the environmental pollution is reduced, and the advantages of environmental friendliness, safety and high efficiency, simple technology and no pollution are realized.

The invention discloses a method for extracting spice oleoresin from spice. The method combines the distillation by water vapour at negative pressure and extraction by a solvent at normal pressure together, namely the method is divided into two steps that: firstly, the spice is distilled by the water vapour at negative pressure and is extracted by the solvent at normal pressure; naphtha and plant alkaloid producing mouthfeel are sequentially extracted; and after residual solvent is removed, certain processing additive is added into the naphtha and plant alkaloid and is mixed with the naphtha and plant alkaloid together according to the requirement of product specification in proportion to prepare a standardized water-soluble or oil-soluble spice oleoresin product. The method ensures that the residual solvent is well controlled in corresponding residual quantity stipulated by national standard, is easy to realize large-scale industrialized production and has the advantage of low processing cost; taking a finished product of the spice oleoresin as 100 percent of total weight, the content of the naphtha in product quality index can be randomly adjusted between 1 and 95 percent; the residual quantity of the solvent can be controlled to be less than or equal to 3 mg / kg; in a conventional process, the content of the naphtha is less than or equal to 50 percent; and the residual quantity of the solvent can be controlled to be between 10 and 20 mg / kg.

A slow-release anticancer medicine containing hormone component for preparing the slow-release implant or slow-release injection is composed of the active anticancer component chosen from hormone-type anticancer medicine and its synergist, and the medicinal additive chosen from polylactic acid, the copolymer of polyoxyacetic acid and hydroxyacetic acid, ethene-vinyl acetate copolymer and polifeprosan.

The invention relates to plant alkaloid compound microemulsion and a preparation method of the plant alkaloid compound microemulsion. The plant alkaloid compound microemulsion is characterized by consisting of the following ingredients in percentage by volume: 8 percent to 12 percent of alkaloid, 12 percent to 18 percent of emulsifying agents, 18 percent to 22 percent of cosolvents and the balance solvents, wherein the alkaloid is total alkaloid prepared from 1.5 to 2.5 weight parts of brunnera and 0.5 to 1.5 weight parts of sophora alopecuroide through ethanol and chloroform extraction, the emulsifying agents are tween-80, the cosolvents are glycol, and the solvents are ethanol with the volume percentage being 75 to 95 percent. The plant alkaloid compound microemulsion disclosed by the invention is compounded by the brunnera and the sophora alopecuroide, the synergia effect among active ingredients is utilized, the medicine effect and the integral prevention and treatment effect of products are improved, the duration is long, low toxicity and environment protection are realized, and the resistance cannot be easily generated in the use process.

The invention provides a glass detergent. The glass detergent comprises, by weight, 10-20 parts of a zwitterionic surfactant, 10-25 parts of an alkali metal saponification liquor, 3-8 parts of potassium sorbate, 5-8 parts of a solubiliser, 5-10 parts of glycerol, 15-30 parts of plant alkaloids and 40-80 parts of water. The glass detergent has the advantages of easy volatilization, fast decontamination, no toxicity and no irritation, is suitable for all automobile windshields, glass windows, mirrors and glass appliances, is convenient to use, has strong decontamination ability, makes the crystal clearness and transparence of the surface of glass to be recovered without water washing, leaves no traces, and can dissolve various types of dirt suspending on the glass.

The invention discloses a method for freezing and concentrating paper-making reconstituted tobacco refining liquid. The method includes the steps of taking 1 L of refined liquid obtained by extracting tobacco raw materials, conducting cooling till the temperature is 0-5 DEG C, placing the refined liquid in a freezing and concentrating tank, selecting refrigerant to cool the refined liquid again so as to lower the temperature, starting a stirring device in the freezing and concentrating tank, generating ice crystals on the wall of the tank, making the ice crystals enter the refined liquid through the stirring effect so that the refined liquid can be secondarily nucleated to generate large ice crystals, opening a valve at the bottom of the tank when the ice crystals mature, and placing the mixture in a low-temperature centrifugal machine to be frozen and centrifuged so that concentrated liquor a and ice crystals b can be obtained; secondly, placing the concentrated liquor a in the freezing and concentrating tank to be secondarily concentrated so that concentrated liquor c and ice crystals d can be obtained; thirdly, weighing the ice crystals d, measuring the solid content of the melted ice crystals d and the solid content and the total sugar, reducing sugar and total plant alkaloid content of the concentrated liquor c. By means of the method, a part of solvent in the solution can be separated out in the form of ice crystals, and therefore the aim of concentrating the solution is achieved, and the existing flavor of a product can be well kept.

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are noscapine analogs. The compounds and compositions can be used to treat and / or prevent a wide variety of cancers, including drug resistant cancers. While the antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in humans, structure-function analyses pointed to a proton at position 9 of the isoquinoline ring that can be modified without compromising tubulin binding activity. Noscapine analogs with various functional moieties at position 9 on the isoquinoline ring kill human cancer cells resistant to other anti-microtubule agents, such as vincas and taxanes. Representative analogs include the 9-nitro, 9-bromo-, 9-iodo-, and 9-fluoro-noscapines, which bind tubulin and induce apoptosis selectively in tumor cells (ovarian and T-cell lymphoma) resistant to paclitaxel, vinblastine and teniposide. Surprisingly, treatment with one of the analogs, 9-nitro-nos, at doses as high as 100 μM, did not affect the cell cycle profile of normal human fibroblasts. This selectivity for cancer cells represents a unique edge over the other available antimitotics. The compounds can perturb the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associated with increased caspase-3 activation and appearance of TUNEL-positive cells. Thus, the compounds are novel therapeutic agents for a variety of cancers, including ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs.

The invention provides a plant insecticide and a preparation method thereof. The plant insecticide is prepared from the following raw materials: datura flowers, ginkgo leaves, solanumerianthum, fructusxanthii, radix aconitiagrestis, semen strychni, tageteserecta, nericumindicum, herbascutellariaebarbatae, croton seeds, radix euphorbiae lantu, and radix sophoraeflavescentis. The preparation method comprises: mixing the raw materials and then crushing the mixture into powder of 50 meshes; putting the powder into an ultrasonic extractor; soaking the powder with water for 2 hours; starting the extractor for extraction; filtering an obtained medicine solution by a 300-mesh filtering machine; then putting the filtered medicine solution into a 35 DEG C low-temperature spray dryer; and performing spray drying to obtain powder, thereby obtaining plant insecticide powder. The plant insecticide provided by the invention has the following advantages: the plant insecticide destroys cell membrane structures and functions of an insect body to lead to death of the insect body according to plant alkaloid and active substances contained in a plant, has a good insecticidal effect, has no toxic or side effects on human and livestock, and is pollution-free to the environment.

A slow-release anticancer injection contains the slow-release microspheres and solvent. Said slow-release microsphere contains the active anticancer component chosen from 6 Pt compounds including bicycloplatinum, etc and 4 cytotoxins including taxane, alkylating agent, topologic enzyme inhibitor, or plant alkaloid, and the slow-release auxiliary.

A composite medicine for treating solid tumors by locally putting it in tumors is composed of the active anticancer component (plant alkaloid and its synergist chosen from Pt compounds, tetraazine medicines and topoenzyme depressant, and the medicinal auxiliary (biocompatible and biogradable high-molecular polymer).

The invention discloses a tobacco processing method for cigar. The processing method comprises the following steps of step one, cleaning and spinning-drying, cleaning, spinning-drying and dehydratingthe tobacco by using an industrial washing machine, and reducing total plant alkaloid; step two, hydrolyzing through enzymic preparation, hydrolyzing the tobacco by using the enzymic preparation, degrading macromolecule protein into polypeptide or amino acid to eliminate hydrophobic bitter peptide; step, high-temperature inactivation and nonenzymatic browning reaction, unfirmly adding mixed sugarcrop in the tobacco after standing in step two, wherein the mixed sugar crop is prepared from the following components in parts by mass, 1-2 part of inverted sugar, 0-2 parts of glucose, 0.1-0.5 partof citric acid, 0.2-1 part of cocoa powder, 0.2-1 part of licorice powder, and 100 parts of tobacco; baking the tobacco at high temperature by using a smoked sheet redrying machine, wherein the bakingtemperature is 130-140 DEG C, and promoting the nonenzymatic browning reaction. The Great wall series or products manufactured by the tobacco is easy and elegant in incense, the smoke concentration,strength, irritation and offensive odor are greatly reduced, the oral aftertaste is sweet, and the smoking durability of the cigar is greatly improved.

An anticancer sustained-release implant is characterized in that active anticancer ingredient is wrapped into pharmaceutical excipient to be made into the sustained-released implant or sustained injection. The active anticancer ingredient is the combination of anti-metabolism anticancer medicine and synergistic agent thereof. The synergistic agent is made from mustine drug and / or antimitotic drug and / or plant alkaloids. The pharmaceutical excipient is made from polylactic acid, copolymer of polyglycolic acid and glycolic acid, ethylene-vinyl acetate copolymer, FAD: sebacic acid (SA) copolymer and / or polifeprosan, etc. The sustained-release injection is composed of sustained release microspheres and menstruum, and the menstruum is classified into common menstruum and special menstruum with suspending agent. The suspending agent is made from sodium carboxymethyl cellulose, mannite, etc. and is used for suspending active anticancer ingredients or sustained-release gains or microspheres containing active anticancer ingredients so as to facilitate injection. Partial tumor placement or sustained-release agent injection can reduce medicine systemic toxicity effect as well as can selectively increase medicine concentration at partial tumor to enhance the curative effect of non-operative treatments such as chemotherapeutic drug, radiation therapy, etc.