The invention discloses a high-pressure extruding and filtering
system for preparing
liposome. The high-pressure extruding and filtering
system disclosed by the invention comprises a high-pressure
homogenizer and one or a plurality of high-pressure extruders in
parallel arrangement, wherein the high-pressure extruder comprises a feeding
pipe, a
flange fixing bolt, a feeding
flange inner sealing
gasket, a constant-temperature water discharging opening, a discharging
pipe, a constant-temperature tank base plate, a base plate outer sealing
gasket, a constant-temperature water feeding opening, a base, an
extrusion outer sealing
gasket, a supporting plate, a filtering plate, a filtering film, an
extrusion inner sealing gasket, a feeding
flange, an upper cover and a locking bolt; the feeding
pipe is arranged at the upper part of the high-pressure extruder and connected to the discharging opening of the high-pressure
homogenizer; and a valve is arranged at the opening of the feeding pipe. The high-pressure extruding and filtering
system disclosed by the invention is connected with one or plurality of high-pressure extruders and the high-pressure extruders are freely switched via the valve, so that the
liposome is prevented from being inflected by bacterium in the process of replacing the filtering film, the
extrusion efficiency is improved, the
liposome with
large particle diameter is effectively reduced, the precise control of the particle
diameter can be realized and the requirement of preparation of liposome medicament can be satisfied.