The invention discloses a diagnosis and treatment preparation with a multi-stimuli-responsive
medicine controlled release function and a preparation method and application thereof. According to the prepared preparation,
polypyrrole nano particles are used as a core and externally modified by a
cyclodextrin-chemotherapeutics compound and a targeted group, and the preparation has the effects of multi-stimuli-responsive
medicine controlled release, photoacoustic imaging and chemotherapeutic and photo-thermal
combined treatment. According to the preparation, three
medicine controlled release mechanisms including pH values,
gelatinase and photo-thermal response are combined, and the selectivity of chemotherapeutics to tumors is improved; imaging and treatment are fused, in-vivo distribution ofthe preparation can be monitored in real time, and the
laser radiation position, power and time during photo-
thermal treatment are guided; and chemotherapeutics and photo-
thermal treatment are combined, so that the
tumor recurrence rate is effectively lowered. By means of the composite preparation, the diagnosis and treatment efficiency is effectively improved, the medical effect is improved, thetoxic and side effects are lowered, and the diagnosis and treatment preparation has good clinic application prospects.