The application relates to compounds with activity against infectious viruses. Accordingly, in one embodiment the invention provides a compound of the invention which is a compound of Formula I: (I) wherein: B is adenine,
guanine cytosine,
uracil,
thymine, 7-deazaadenine, 7-deazaguanine, 7-deaza-8-azaguanine, 7-deaza-8-azaadenine,
inosine, nebularine, nitropyrrole, nitroindole, 2-
aminopurine, 2-amino-6-chloropuriine, 2,6-diaminopurine,
hypoxanthine, pseudouridine, pseudocytosine, pseudoisocytosine, 5-propynylcytosine, isocytosines, isoguanine, 7-deazaguanine, 2-thiopyrimidine, 6-thioguanine, 4-thiothymine, 4-
thiouracil O<6> -methylguanine, N<6> -methyladenine, O<4>-methylthymine, 5,6-dihydrothymine, 5,6-dihydroucacil, 4-methylindole,
triazole, or pyrazolo[3,4-d]
pyrimidine; and B is optionally substituted with one or more
alkyl, alkenyl, alkynyl, cycloalkyl, (cycloalkyl)
alkyl, hydroxy, or halo; and R<1> is
alkyl, alkenyl, alkynyl, cyano, azido, or fluoromethyl; or a pharmaceutically acceptable salt or solvate thereof.