The invention discloses an antifeezing and anti-blocking method of a natural gas runner, which comprises the following steps: periodically adding antifreeze into the natural gas runner so as to reduce the dew point of the natural gas and the freezing point of the water in the natural gas runner, and prevent the water from freezing and blocking the natural gas runner. The invention can effectively solve the problems that the natural gas runner is frozen and blocked, mixed solid content formed by natural gas hydrate and ice block the natural gas runner, also can greatly reduce the dew point of the natural gas, cosmically simplify the productive process of the natural gas, particularly, cosmically simplify the natural gas ground surface gathering process, greatly reduce the cost of the natural gas production, energy consumption, gas self consumption, management working load, and the like, fundamentally eliminate methanol harm and pollution in the natural gas production, realize non alcoholization of the natural gas productive process, and has the advantages of easy implementation, safety and reliability, wide application, easy popularization and the like. The economic benefit, environmental protection benefit and safety benefit are remarkable.