34 results about "Radiation-Protective Effects" patented technology

The invention discloses medical hydrogel. The medical hydrogel is formed by in-situ crosslinking of formyl-terminated star-shaped multi-arm polyethylene glycol and a poly-amino compound. Formyl groupsare connected with star-shaped multi-arm polyethylene glycol through chemical bonds such as an ether bond, an amide bond, an urethane bond and an imine bond or a urea bond, wherein the molar ratio ofamino groups in the poly-amino compound to the formyl groups in formyl-terminated star-shaped multi-arm polyethylene glycol is (0.4-4.4):1. The poly-amino compound is polylysine or a mixture of polylysine and polyethyleneimine, and the molar ratio of polylysine to polyethyleneimine is (2-30):3. The hydrogel is high in gel formation speed, has long-term stability in an aqueous solution, still maintains good swelling performance and high stability after being subjected to irradiation several time, and can be used as a medical radiotherapy protection pad for radiation protection.

Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount of cerium oxide nanoparticles to the subject to mitigate the effects of radiation exposure or to offer a radioprotective effect to the subject. The cerium oxide nanoparticles are suitably less than 20 nm in diameter and have over 50% of the cerium in the 3+ oxidation state.

The invention discloses a new use of 3,5-dimethoxy-4-hydroxy benzaldehyde which is an application of 3,5-dimethoxy-4-hydroxy benzaldehyde in alpha-particle ray damage protection. Test proves that, in the test of cell culture in vitro and ray irradiation with alpha-particle ray, the cell of 3,5-dimethoxy-4-hydroxy benzaldehyde is added in the culture system; the clone forming rate after irradiation is obviously higher than that of the cell without adding medicants, and the gene mutation rate caused by irradiation is obviously lower than that of the cell without adding medicants. Therefore, 3,5-dimethoxy-4-hydroxy benzaldehyde can reduce gene group DNA damage and gene mutation caused by ray irradiation and has the effect of irradiation protection.

The invention relates to the technical field of a traditional Chinese medicine, particularly relates to a compound traditional Chinese medicine for radiation protection, and discloses a compound traditional Chinese medicine for radiation protection. The compound traditional Chinese medicine is characterized by being prepared from the following components in parts by weight: 21-62 parts of astragalus membranaceus, 1-8 parts of grape pip, 16-46 parts of acanthopanax, 7-29 parts of rhizoma dioscoreae and 1-7 parts of spina date seed. Compared with the existing other medicines for radiation protection and treatment, the compound traditional Chinese medicine disclosed by the invention has the significant advantages and effects that 1, the medicine is convenient to use; 2, the medicine has a radiation protection effect and also has an auxiliary radiation injury treatment effect; 3, the medicine is refined from folk common herbs, and is good in pharmaceutical effect and free of toxic and side effects; 4, the used raw materials are common Chinese herbal medicines in China, and the compound traditional Chinese medicine is wide in distribution, and low in price, and is one of the advantages in future development and application.

The invention provides a new compound with a radiation protection function, and pharmaceutically acceptable salt, pro-drug and solvate. The compound and the pharmaceutically acceptable salt, pro-drug and solvate are as shown in formula (I): a chemical formula is shown in the original PDF, wherein W is selected from carbonyl, sulfoxide and sulfonyl; R<1> is selected from substituted or un-substituted aromatic ring or aromatic heterocycle: chemical formulae are shown in the original PDF; X is selected from carbon and nitrogen; R<4> is selected from hydrogen, halogen, cyan, substituted or un-substituted C1-3 alkyl or alkoxy, methyl, trifluoromethyl, methoxyl, and trifluoromethoxy; R<2> is selected from the following perssad: chemical formulae are shown in the original PDF; R<3> is selected from hydrogen, methyl, vinyl and the like; when the W is selected from the sulfonyl, and the R<1> is selected from 4-fluorophenyl, 4-chlorophenyl, 4-iodophenyl and 4-trifluoromethoxy phenyl, the R<2> cannot be selected from 4-carboxyphenyl and 4-carboxyphenyl sodium, and the R<3> cannot be selected from the hydrogen; and when the W is selected from the sulfoxide and the R<1> is selected from 4-fluorophenyl, 4-chlorophenyl, and 4-iodophenyl, the R<2> cannot be selected from 4-carboxyphenyl and 4-carboxyphenyl sodium, and the R<3> cannot be selected from the hydrogen.

The present disclosure relates to methods for preventing or treating a radiation-induced disease, disorder, or condition by administering apilimod to a subject in need thereof, and related compositions.

The present invention relates to the technical field of medicine, and specifically relates to a PUMA inhibitor, a method for preparation thereof, and a use thereof. The PUMA inhibitor is the compound as shown in (I) or a pharmaceutically acceptable salt thereof. The definitions of its substituent groups are as described in the description. The compound (I) or pharmaceutically acceptable salt thereof is capable of targeting a PUMA protein and has very good physicochemical properties, very good apoptosis resistance and radiation protection effects; it can selectively inhibit the competitive combined effect of a PUMA protein and a Bcl-2 apoptosis-resistant protein, block apoptosis, and effectively protects against bone marrow damage. The present invention provides a new idea for, and powerful proof of, the application of a PUMA-protein small molecule inhibitor in radiation-protection pharmaceuticals, and is likely to become a highly effective, low-toxicity, and stable clinical radiation-protection pharmaceutical.

The invention discloses an easy-to-wear radiation protective medical isolation garment which mainly comprises an isolation garment body, an airbag waist belt, an airbag neck band, airbag wrist bands,airbag leg bands, an air control device, a clamp strip disc, a connecting strip and a docking strip. The air control device is located on the left side of the front side of the airbag waist belt, a power supply bin is arranged on the right side of the air control device, an air control button is arranged on the outer surface of the power supply bin, a clamp strip control button is arranged on theright side of the control button, the clamp strip disc is located on the rear surface of the head of the isolation garment body, opening clamp strips including the connecting strip and the docking strip which are used for wearing are arranged on the back of the isolation garment body, the connecting strip and the docking strip are respectively connected with two track grooves in the upper end of the rear surface of the airbag wrist band through sliders, each track groove is provided with a telescopic airbag therein, and the telescopic airbags are fixedly connected with the corresponding sliders. In short, the medical isolation garment is convenient in use, quick in wearing and remarkable in radiation protective effect.