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Application of glycyrrhetinic acid in preparation of anti-radiation product

A technology of glycyrrhetinic acid and anti-radiation, which is applied in the fields of food, medicine, and beverages. It can solve the problems of glycyrrhetinic acid and other issues that have not been reported in the literature, and achieve the effects of preventing or treating radiation damage, slowing down damage, and less toxic and side effects

Inactive Publication Date: 2015-10-28
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no literature report on the relationship between glycyrrhetinic acid and radiation protection

Method used

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  • Application of glycyrrhetinic acid in preparation of anti-radiation product
  • Application of glycyrrhetinic acid in preparation of anti-radiation product
  • Application of glycyrrhetinic acid in preparation of anti-radiation product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. Protective Effect of Glycyrrhetinic Acid on Cell Damage Caused by Radiation

[0024] 1.1 Experimental materials

[0025] Glycyrrhetinic acid was purchased from Dalian Meilun Biotechnology Co., Ltd.

[0026] Human umbilical vein endothelial cell line (HUVEC) was purchased from Shanghai Cell Bank of Chinese Academy of Sciences.

[0027] 1.2 Experimental method

[0028] 1.2.1 MTT method to detect the protective effect of glycyrrhetinic acid on radiation-induced cell damage

[0029] The experiment was divided into a control group (no radiation, no drug administration), a model group (radiation, no drug administration), and a drug administration group (radiation, drug administration).

[0030] Take HUVEC cells in the logarithmic growth phase at 1.0×10 5 Inoculate in a 96-well plate at a density of 100 μL per well, 24 hours after inoculation, and wait for the cells to adhere to the wall, then replace with serum-free DMEM medium and continue to incubate for 8 ho...

Embodiment 2

[0046]Example 2. The protective effect of glycyrrhetinic acid on radiation-induced injury in mice

[0047] 2.1 Experimental materials

[0048] Glycyrrhetinic acid was purchased from Dalian Meilun Biotechnology Co., Ltd.

[0049] C57 mice were purchased from Shanghai Slack Experimental Animal Co., Ltd., license number SCXK (Shanghai) 2012-0002.

[0050] 2.2 Experimental method

[0051] 2.2.1 The effect of glycyrrhetinic acid on the survival rate of radiation-induced mice

[0052] C57 mice were given different doses of glycyrrhetinic acid (30, 60mg / kg / d) for two weeks, and then 8Gy 60 Co-gamma ray was irradiated. After the radiation, the mice continued to be administered orally, and the survival rate of the mice within 30 days after the radiation was observed.

[0053] 2.2.2 Effect of glycyrrhetinic acid on radiation-induced small intestinal tissue damage in mice

[0054] After gavage administration of glycyrrhetinic acid (60mg / kg / d) to C57 mice for two weeks, they received...

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Abstract

The invention relates to the technical fields of medicine, food and beverage, and provides application of glycyrrhetinic acid in preparation of anti-radiation products. Cell experiments and animal experiments confirm that glycyrrhetinic acid can increase the survival rate of cells and animals after gamma-ray radiation, reduce apoptosis induced by gamma-ray, and improve intestinal tissue lesions of the radiated mouse; therefore, it indicates that glycyrrhetinic acid has anti-radiation protective effects.

Description

technical field [0001] The invention relates to the technical fields of medicine, food, beverage, etc., and specifically relates to a new application of glycyrrhetinic acid, that is, a new application of glycyrrhetinic acid in preparing anti-radiation products. Background technique [0002] As nuclear technology is widely used in military affairs, science and technology, medical treatment and production, people have more and more opportunities to be exposed to various rays, and the possibility of suffering radiation damage is also increasing. When radiation acts on organisms, it will cause ionization and produce free radicals, and then a series of biochemical reactions will occur, which will change the permeability of cell membranes, attack DNA, RNA and protein macromolecules, and cause cells to lose their normal functions. Lymphocytes in the human body are most sensitive to ionizing radiation, followed by gonad cells, proliferating bone marrow cells, intestinal epithelial c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P17/16A61P39/00A23L1/29A23L2/52A23L2/38
Inventor 王静侯楠刘玉兰朱秋珍程浩柴逸峰高越章越凡李铁军芮耀诚
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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