39 results about "Oxacillin Sodium" patented technology

The invention relates to synthesis and application of an antibacterial medicine ASC for targeted treatment of MRSA (methicillin-resistant staphylococcus aureus) and SAU (staphylococcus aureus) infection and for treatment of super bacterium infection by being cooperated with antibiotics. The effective concentration of the ASC for treating the MRSA infection is 2 mug / mL; the efficacy is 4 times higher than the efficacy of standard medicine oxacillin; the dosage of 35 mg / kg can realize the specific effect treatment on mouse heart and lung MRSA infection, and the MRSA colonization quantity in liver, spleen and kidney tissues of the mouse can be obviously reduced. The ASC is also a broad spectrum inhibitor of antibiotic drug resistant target protein metal beta-lactamase, and can be cooperated with beta-lactamase, aminoglycoside and tetracycline type medicine to realize the targeted treatment of SAU infection; through the dose of 1 mug / mL, the curative effects of antibiotics can be improvedto 4 to 128 times; through the dose of 64 or 8 mug / mL, the curative effect of Xianfeng V on NDM-1 or CcrA producing medicine-resistance bacteria E.coli is improved by 32 times.

The invention relates to a composition of prodigiosin and oxacillin or its derivatives, wherein the mass ratio of prodigiosin and oxacillin or its derivatives is 1 to 2.55:1, and the invention also provides the above-mentioned The composition is used in preparing and treating infectious diseases of methicillin-resistant staphylococcus aureus, and provides a medicine for treating infectious diseases of methicillin-resistant staphylococcus aureus. The composition of the invention and the medicine containing the composition have significantly higher antibacterial effect than the single components of the two.

The invention discloses a Nocardia culture medium. The Nocardia culture medium is characterized in that the formulation for preparing 1000 ml of the culture medium contains 2-4 g of soluble starch, 10-20 g of bovine liver powder, 0.005-0.02 g of oxacillin, 3-5 million units of multisubtilin, 0.1-0.4 g of allithiamine, 0.01-0.2 g of inositol, 0.8-1.1 g of magnesium sulfate, 15-20 g of agar, and distilled water which is added to reach the total volume of 1000 ml. Compared with the prior art, the Nocardia culture medium has the characteristics of reliable detection and high separation rate.

The invention discloses a midget anti drug-tolerance staphylococcus aureus polypeptide comprised of passage structure domain to form ion channel colicine and staphylococcus aureu pheromone, as well as opposite coded nucleotide sequence and recombination plasmid contained said sequence. Wherein, the plupeptide can not induce bacteria to generate trsditional drug-tolerance by the mechnism that it forms directly ion channel on cell film of target cell to kill bacteria. This invention has more single antimicrobial spectrum without effect to Gram-negative bacteria of escherichia coli, shows at least 500 times effect to pheneazonecillin, and can be used as synergist to beta-lactam antibiotics.

The invention belongs to the field of pharmacy, and relates to the use of spiroketal polyacetylene compounds in the preparation of sensitization drugs for drug-resistant Staphylococcus aureus. Oxacillin can produce antibacterial and synergistic effects in a synergistic manner, especially through the combination of spiroketal polyacetylenes and oxacillin, it can significantly reduce the minimum inhibitory concentration of oxacillin, and has a negative effect on oxacillin. Synergistic effect against drug-resistant Staphylococcus aureus. The spiroketal polyacetylene compound can be used in the sensitization drug against the multi-drug resistant Staphylococcus aureus strain EMRSA‑16 containing the mecA efflux pump drug resistance gene, and the compound and oxacillin A pharmaceutical composition with anti-drug-resistant Staphylococcus aureus effect.

The invention relates to a preparation method of oxacillin film-coated tablets, belonging to the technical field of medicines. The white pill of the oxacillin film-coated tablets is composed of the following components in percentage by weight: 78-90% of oxacillin sodium, 2-4% of talc, 5-10% of starch filler and 0.5-1.5% of magnesium stearate; the film coating agent is composed of the following components in percentage by weight: 3.5-5% of gastric-soluble coating agent, 0.06-0.09% of Tween-80 and 0.09-0.13% of talc; and the coating agent is prepared into a coating solution the solid content ofwhich is 8-11% with a 80% ethanol aqueous solution for use. In the invention, the difficulty in coating oxacillin sodium tablets and irregular tables are solved, and the oxacillin film-coated tabletscan be prepared.

Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.