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Application of vanillic acid in inhibiting growth of multi-drug-resistance staphylococcus aureus

A staphylococcus, multi-drug resistance technology, applied in the direction of antibacterial drugs, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effect of solving drug-resistant infections, reducing mortality, and wide application value

Pending Publication Date: 2019-04-19
SHAANXI UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

No reports on the use of vanillic acid as an active ingredient for inhibiting multi-drug resistant Staphylococcus aureus

Method used

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  • Application of vanillic acid in inhibiting growth of multi-drug-resistance staphylococcus aureus
  • Application of vanillic acid in inhibiting growth of multi-drug-resistance staphylococcus aureus
  • Application of vanillic acid in inhibiting growth of multi-drug-resistance staphylococcus aureus

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Embodiment Construction

[0014] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0015] 1. Drug susceptibility test of human Staphylococcus aureus

[0016] The present invention takes 10 strains of human Staphylococcus aureus (strain samples taken from the Center for Disease Control and Prevention) as starting strains, and selects linezolid, trimethoprim, gentamicin, ciprofloxacin, penicillin, and cefazolin , clindamycin, vancomycin, oxacillin, piperacillin 10 kinds of commonly used antibiotic susceptibility test strips for drug susceptibility test.

[0017] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the plate, and ...

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Abstract

The invention discloses application of vanillic acid in inhibiting growth of multi-drug-resistance staphylococcus aureus. The inhibition effect of the vanillic acid on humanized multi-drug-resistancestaphylococcus aureus is put forward based on the fact that the vanillic acid has a good in-vitro killing effect on humanized multi-drug-resistance staphylococcus aureus which is resistant to linezolid, trimethoprim, gentamicin, ciprofloxacin, penicillin, cefazolin, clindamycin, vancomycin, oxacillin and piperacillin, and can inhibit the growth of multi-drug-resistance staphylococcus aureus, wherein the minimum bactericidal concentration is 2.4 mg / mL, and the minimum inhibitory concentration is 0.3 mg / mL. By means of the vanillic acid, drug-resistance infection of multi-drug-resistance staphylococcus aureus can be effectively relieved or solved, the mortality is reduced, a new idea is put forward for inhibition of humanized multi-drug-resistance staphylococcus aureus, and the vanillic acidhas important practical significance.

Description

technical field [0001] The invention relates to the research, development and application of vanillic acid, an active ingredient of traditional Chinese medicine, as an inhibitor of Staphylococcus aureus, in particular to the application of vanillic acid in inhibiting the growth of multidrug-resistant Staphylococcus aureus. Background technique [0002] Staphylococcus aureus (Staphylococcus aureus) is the main pathogenic bacterium that causes human infectious diseases. It can cause many serious infections, and can also cause pneumonia, pseudomembranous enteritis, pericarditis, etc. The widespread use and overuse of antibiotics has led to the continuous increase of bacterial resistance, leading to the continuous spread of bacterial resistance around the world, and the continuous emergence of "super bacteria", which has become the focus of global attention. The emergence of multidrug-resistant bacteria has brought great challenges to clinical treatment. For example, ineffective...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P31/04
CPCA61K31/192A61P31/04
Inventor 钱卫东沈兰芳王婷刘婵婵刘淼张家宁孙照欢杨敏
Owner SHAANXI UNIV OF SCI & TECH
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