Application of citral in inhibiting the growth of multi-drug resistant Enterobacter hallii

A technology for treating Enterobacter horii and Enterobacter horii is applied in the application field of citral in inhibiting the growth of multi-drug resistant Enterobacter horii, and can solve the problems such as research reports on Enterobacter horii that have not yet been found, and achieves a solution to the problem. The problem of drug-resistant infection, reducing the fatality rate, and the effect of widespread application value

Active Publication Date: 2022-04-29
SHAANXI UNIV OF SCI & TECH
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Problems solved by technology

However, no research reports on the inhibition of Enterobacter hallii by citral have been found

Method used

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  • Application of citral in inhibiting the growth of multi-drug resistant Enterobacter hallii
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  • Application of citral in inhibiting the growth of multi-drug resistant Enterobacter hallii

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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the examples. The embodiments are only used to explain the present invention, not to limit the protection scope of the present invention.

[0016] 1. Drug susceptibility test of human Enterobacter hallii

[0017] In the present invention, two strains of human-derived Enterobacter hallii are used as starting strains (strain samples are taken from the General Hospital of the Chinese People's Liberation Army), and piperacillin, gentamicin, bromogmentine, imipenem, and ofloxacin are selected. , nitrofurantoin, ceftaquine, nalidixic acid 8 kinds of antibiotic susceptibility test strips for drug susceptibility test.

[0018] The pure colonies picked and cultured for 18-24 hours were evenly dissolved in 2-5 mL sterile saline, and the turbidity was adjusted to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of bacterial solution, spread evenly on the plate, a...

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Abstract

The invention discloses the application of citral in inhibiting the growth of multidrug-resistant Enterobacter hallii. Nalidixic acid has good in vitro killing effect on multidrug-resistant Enterobacter hallii, and can inhibit the growth of multidrug-resistant Enterobacter hallii, and the minimum bactericidal concentration is 2.8mg / mL, and the minimum inhibitory concentration is 2.4mg / mL. mL, the present invention proposes the inhibitory effect of citral on multidrug-resistant Enterobacter hallii, which has wide application value in the field of medicine.

Description

technical field [0001] The invention relates to the research, development and application of citral, an active ingredient of traditional Chinese medicine, as a bacterial inhibitor, in particular to the application of citral in inhibiting the growth of multidrug-resistant Enterobacter hallii. Background technique [0002] Enterobacter hormaechei (Enterobacter hormaechei) is a Gram-negative bacterium, facultatively anaerobic, easy to grow on ordinary medium, and exists in the intestinal tract of humans and animals. Enterobacter hallii can cause infection in animals and humans under certain conditions. It is an opportunistic pathogenic bacterium that can be isolated from infected animals or animal wounds. Cases caused by its infection include stroke (Ming Desong, Zhu Yan, Xie Zunjin. Study on drug resistance and drug resistance mechanism of sputum Enterobacter Halemannii in stroke patients[J]. Chinese Journal of Hospital Infection, 2011, 21(05): 1025-1026.), Bacteremia in prema...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/11A61P31/04
CPCA61K31/11A61P31/04
Inventor 钱卫东沈兰芳王婷杨敏刘淼李鑫辰王文静付玉婷
Owner SHAANXI UNIV OF SCI & TECH
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