Application of vanillic acid in inhibiting the growth of multi-drug resistant Enterobacter hallii

A technology for treating Enterobacter halleri and Enterobacter halleri, applied in the application field of vanillic acid in inhibiting the growth of multi-drug-resistant Enterobacter halleri, to achieve the effect of reducing mortality, solving the problem of drug-resistant infection, and having wide application value

Active Publication Date: 2021-08-13
SHAANXI UNIV OF SCI & TECH
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  • Abstract
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Problems solved by technology

However, the report about using vanillic acid as an active ingredient to inhibit the growth of Enterobacter hallii has not yet been seen.

Method used

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  • Application of vanillic acid in inhibiting the growth of multi-drug resistant Enterobacter hallii
  • Application of vanillic acid in inhibiting the growth of multi-drug resistant Enterobacter hallii
  • Application of vanillic acid in inhibiting the growth of multi-drug resistant Enterobacter hallii

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Embodiment Construction

[0016] The present invention will be described in further detail below in conjunction with the examples. The examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0017] 1. Drug susceptibility test of Enterobacter hallii

[0018] The present invention takes human Enterobacter hallii as the starting strain (the strain sample is taken from the Center for Disease Control and Prevention), and piperacillin, levofloxacin, gentamicin, broguementin, imipenem, ofloxacin, Antimicrobial susceptibility tests were carried out on 10 commonly used antibiotics, nitrofurantoin, ceftaquine, azithromycin, and nalidixic acid.

[0019] Pick and culture a single colony for 18-24 hours and evenly dissolve it in 2-5 mL sterile saline, adjust its turbidity to be equal to that of a 0.5 McFarland turbidimetric tube. Aseptically draw 50-200 μL of the bacterial solution, spread the bacterial solution evenly on the plate with a cotton swab,...

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Abstract

The invention discloses the application of vanillic acid in inhibiting the growth of multidrug-resistant Enterobacter hallii. Quincin, azithromycin and nalidixic acid have good in vitro killing effect on multidrug-resistant Enterobacter hallii, and can inhibit the growth of multidrug-resistant enterobacter hallii, and the minimum bactericidal concentration is 3.2mg/mL, the minimum inhibitory concentration It is 1.6 mg/mL, and the invention proposes the inhibitory effect of vanillic acid, an active ingredient of traditional Chinese medicine, on multidrug-resistant Enterobacter hallii, which has wide application value in the field of medicine.

Description

technical field [0001] The invention relates to the application of vanillic acid, an active ingredient of traditional Chinese medicine, as an inhibitor of enterobacteriaceae, in particular to the application of vanillic acid in inhibiting the growth of multidrug-resistant enterobacteria hallii. Background technique [0002] Enterobacter hormaechei (Enterobacter hormaechei) belongs to Gram-negative enteric bacilli, and is the main intestinal pathogenic bacterium that causes infectious diseases in humans or animals. It can cause diarrhea, enteritis, and gastrointestinal tract infections in humans or animals. And in recent years, the potential harm of Enterobacter hallmannii has been increasing day by day. Some scholars (Ming Desong, Zhu Yan, Xie Zunjin. Research on drug resistance and drug resistance mechanism of Enterobacter hallmannii in stroke patients[J]. Chinese hospital infection Journal of Science, 2011,21(05):1025-1026.) Enterobacter hallii was isolated from infant mil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/192A61P31/04
CPCA61K31/192A61P31/04
Inventor 钱卫东杨敏王婷沈兰芳刘淼孙照欢张家宁王文静
Owner SHAANXI UNIV OF SCI & TECH
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