399 results about "Ionic Channels" patented technology

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

A portable Static Electro Magnetic Field (SEMF) generating device and method for the therapeutic treatment of inflammatory and painful disorders of the human limbs including fingers, hands, wrists, forearms, elbows, toes, feet and ankles preferably includes a wearable, portable battery powered solenoid or coil. The coil is configured to focus a substantially time invariant magnetic flux field onto a selected part of the body. The SEMF generating device's coil, when energized, works by slightly changing the charges associated with voltage-dependant ion channels in the cell membranes of the human body, thereby stabilizing abnormal fluid transport into the cells through aquaporin channels and the sodium ions relating to them, treating inflammation and altering the flow of calcium, chloride and potassium ions through their respective neuronal ion channels and treating pain.

The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit.

The invention discloses a preparation method and application of a transparent titanium dioxide nanotube film. Firstly, a titanium sheet is subjected to a primary anodic oxidation, ultrasonic cleaning and secondary anodic oxidation to form a titanium dioxide nanotube array; the titanium dioxide nanotube array is subjected to low temperature annealing; the titanium dioxide nanotube array is quickly peeled from a substrate titanium through high-voltage anodization to obtain the titanium dioxide nanotube self-supporting film with a regular shape and two transparent ends. The preparation method is simple, low in price, environment-friendly and beneficial for large-scale application. The low temperature annealing treatment can effectively protect the strength and the thickness of the film and has very important effect on the film application. The preparation method and the application of the transparent titanium dioxide nanotube film utilize intelligent response functions of ion channels in titanium dioxide nanotube film simulated organisms to built artificial ion channels with photoresponse, and overcome the instability of organic materials in the traditional artificial ion channels and the limitation of biological material application.

A compound of formula (I)

wherein A, R¹, R³, and R²⁴ are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, I_Kur-associated disorders, and other disorders mediated by ion channel function.

The invention discloses a long-branched-chain polysulfone anionic membrane and a preparation method thereof. The structure of the membrane material is disclosed in the specification. The preparation method comprises the following steps: polysulfone acylation, carbonyl reduction, quaternization, film formation, alkalification and the like. Compared with the traditional anion-exchange membrane sequentially subjected to quaternization and functionalization, the polysulfone anion-exchange membrane contains the long branched chain on the side chain, so that the hydrophilic group is far away from the hydrophobic polymer main chain, thereby enhancing the phase separation driving force in the film formation process, improving the connectivity of the ion channels in the membrane and further enhancing the hydroxide ion conductivity of the membrane. The long alkyl side chain can obviously reduce the degree of swelling of the quaternary ammonium salt membrane and reduce the nucleophilic attack of water or OH-. The long-branched-chain polysulfone anionic membrane can obtain higher ion conductivity on the premise of relatively lower water absorptivity, thereby solving the contradiction in the anionic membrane for a long time.

The invention relates to a specific probe substrate composition of cytochrome P450 (CYP450) enzyme and an application of the specific probe substrate composition in subtype enzyme activity detection of the cytochrome P450 enzyme. The composition comprises at least two of phenacetin, coumarin, amfebutamone, dextromethorphan, diclofenac and testosterone. The characteristics of multi-ion channels can be simultaneously detected by the specific probe substrate composition and a liquid chromatography-mass spectrometry technology, and the inhibition conditions of six CYP450 enzymes are determined simultaneously, so that the experiment flux efficiency is greatly improved, and the experiment cost is reduced.

The invention discloses an isoquinoline compound or salt thereof shown as a formula I, wherein R1 and R2 are H, -OCH3 and -OCH2Ph or -NHSO2CH3 independently or R1 and R2 are connected into -OCH2O-; R3 is -NO2, -NH2 or -NHSO2CH3; and R4, R5, R6 and R7 are independently H, -OCH3, -NO2, -NH2 or -NHSO2CH3. The invention also discloses a preparation method of the compound, the medicinal composition containing the compound, and application of the compound in preparing medicaments for treating anti-arrhythmia. The isoquinoline compound or salt thereof has the effect of potassium ion channel blocker, and shows effective activity of prolonging effective refractory period and better heart selectivity, so the isoquinoline compound or salt thereof has better anti-arrhythmia activity.

The invention discloses a midget anti drug-tolerance staphylococcus aureus polypeptide comprised of passage structure domain to form ion channel colicine and staphylococcus aureu pheromone, as well as opposite coded nucleotide sequence and recombination plasmid contained said sequence. Wherein, the plupeptide can not induce bacteria to generate trsditional drug-tolerance by the mechnism that it forms directly ion channel on cell film of target cell to kill bacteria. This invention has more single antimicrobial spectrum without effect to Gram-negative bacteria of escherichia coli, shows at least 500 times effect to pheneazonecillin, and can be used as synergist to beta-lactam antibiotics.

Methods of using imidazo[1,2-α]pyridine ether compounds for modulating ion channel activity in a warm-blooded animal are disclosed.