Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for detecting oxacillin SERS by using superparamagnetic Fe<3>O<4>@SiO<2>@Ag nano composite material

A nano-composite material, oxacillin technology, which is applied in analytical materials, material excitation analysis, preparation of test samples, etc., can solve the problems of irregular aggregation of Ag nanoparticles, unsatisfactory detection effect, and high requirements for reaction conditions. Achieve the effect of improving sensitivity, good superparamagnetic performance and shortening detection time

Inactive Publication Date: 2019-08-02
GUANGXI UNIVERSITY OF TECHNOLOGY
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this detection method is cumbersome, and due to the irregular aggregation of dispersed Ag nanoparticles, the detection repeatability is poor.
At the same time, there are fewer "hot spots" between Ag nanoparticles, and the SERS activity is lower and the sensitivity is not high.
Therefore, Hu et al. prepared Fe 3 o 4 @SiO 2 The @AgNPs composite is used as a SERS substrate, and its performance is studied, but its preparation process is cumbersome, time-consuming, and the detection effect is not ideal
[0005] In the current public literature, "Ag / Fe 3 o 4 @SiO 2 Preparation of magnetic nano-adsorbent and its deep desulfurization performance of gasoline" discloses an Ag / Fe 3 o 4 @SiO 2 The preparation method of magnetic nanomaterials, which uses thermal decomposition to deposit silver, has the disadvantages of time-consuming, cumbersome preparation process, high requirements for reaction conditions (need to be calcined at 500 ° C for 2 hours), and the prepared Ag / Fe 3 o 4 @SiO 2 Magnetic nanomaterials used as adsorbents, not substrates for surface-enhanced Raman

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for detecting oxacillin SERS by using superparamagnetic Fe&lt;3&gt;O&lt;4&gt;@SiO&lt;2&gt;@Ag nano composite material
  • Method for detecting oxacillin SERS by using superparamagnetic Fe&lt;3&gt;O&lt;4&gt;@SiO&lt;2&gt;@Ag nano composite material
  • Method for detecting oxacillin SERS by using superparamagnetic Fe&lt;3&gt;O&lt;4&gt;@SiO&lt;2&gt;@Ag nano composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: A method for the SERS detection of oxacillin by a superparamagnetic Fe3O4@SiO2@Ag nanocomposite material, comprising the following steps:

[0036] (1) Determine the characteristic Raman peak and peak movement range: 1028cm -1 ±10cm -1 is the characteristic Raman peak;

[0037] (2) Draw the oxacillin standard curve: Accurately weigh 4mg of oxacillin standard substance, dilute it in a 10mL volumetric flask with hydrochloric acid aqueous solution (pH3.0), dilute the above solution to different multiples, and use a Raman spectrometer For detection, the Raman spectrum of the oxacillin standard substance is baseline adjusted and normalized to obtain the oxacillin standard curve;

[0038] (3) Preparation of the sample solution to be tested: Grind 4mg oxacillin capsules (remove its outer shell), and the tablet sample to be tested, dissolve in aqueous hydrochloric acid solution of pH 3.0 and set the volume to 10mL, to obtain the sample solution to be tested;

[...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for detecting oxacillin SERS by using superparamagnetic Fe<3>O<4>@SiO<2>@Ag nano composite material. Fe<3>O<4>@SiO<2>@Ag nano composite material is used as SERS active substrate. The preparation method of the SERS active substrate Fe<3>O<4>@SiO<2>@Ag nano composite material takes Fe<3>O<4> as a core and takes SiO<2> as a shell to construct a Fe<3>O<4>@SiO<2> core-shell structure, Ag nano particles are formed by utilizing the isotropic growth of Ag species and the stabilizing action of polyvinylpyrrolidone (PVP) and are deposited on the core-shell structure, the Fe<3>O<4>@SiO<2>@Ag core-shell structure which is good in dispersion, good in magnetic response, high in sensitivity and integrated is obtained. The method for detecting the oxacillin SERS has the advantages of simplicity, rapidness, high integration, good reproducibility and high sensitivity, and can be used for rapidly detecting the oxacillin in various dosage forms.

Description

technical field [0001] The invention relates to a superparamagnetic Fe 3 o 4 @SiO 2 A method for SERS detection of oxacillin using @Ag nanocomposites. Background technique [0002] At present, the commonly used methods for detecting oxacillin mainly include methods such as high performance liquid chromatography, liquid-mass spectrometry (HPLC-MS), high performance liquid chromatography-ultraviolet (HPLC-UV), and gel chromatography. , the detection cycle is long, and the sensitivity and detection limit are low, so rapid detection cannot be realized. Surface-enhanced Raman scattering (SERS) uses photons as molecular probes to achieve non-destructive and rapid detection of substances, and the selection of SERS active substrates is particularly important for SERS detection. [0003] In 1977, Jeanmaire and Van Duyne found that the Raman signal intensity was abnormally enhanced by a million times on the rough Ag electrode surface. Further studies have found that a small amoun...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65G01N1/28
CPCG01N1/286G01N21/658G01N2001/2866
Inventor 冯军李利军程昊黄文艺孔红星李彦青徐亚娟
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com