The invention relates to a machining process of a large duplex stainless steel impeller. The machining process comprises the steps of casting, thermal treatment of a front deformation protector, solutionizing treatment, finishing and rough polishing, component re-inspection, mechanical property inspection, RT radiographic inspection, defect treatment, repair welding and rough polishing, rough machining, trimming, stress relief thermal treatment, semi-finish machining, fine polishing, finish machining, balance test duplicate removal and the like. The machining process is small in hardening effect, small in dimension deformation, good in impeller machining dimension accuracy and high in surface smoothness. The work completion size inspection is controlled at the temperature lower than 40 DEG C. In addition, the processing efficiency is high, the quality is good, the dimensional accuracy and the position dimension tolerance deformation of the impeller can be ensured to be small, and the graph dimension requirement and the technical requirements can be met.