116 results about "Chitosan hydrochloride" patented technology

The invention discloses an edible film with a continuous antioxidant function and a preparation method and application thereof. Preparation parameters of tea polyphenol-chitosan hydrochloride nanoparticles are adjusted, and the prepared chitosan hydrochloride nanoparticles with different tea polyphenol encapsulation rates and particle sizes are added to a natural edible biological macromolecular film formation matrix so as to form the film. On one hand, the different encapsulation rates can change the proportion of free tea polyphenol to encapsulated tea polyphenol in the film; on the other hand, the nanoparticles in different sizes can adjust structure compactness of the film, and therefore release of the tea polyphenol in the film is coordinated and controlled. According to the edible film with the continuous antioxidant function and the preparation method and the application of the edible film, when the antioxidant film is prepared, release of active substances can be adjusted under the condition that the concentration of the active substances is definite, and the use rate of the active substances in the film is increased.

The invention relates to the field of medical dressings / sprays, in particular to wound repair liquid and a preparation method thereof. The wound repair liquid contains cell factors, a film forming material and a solvent. The cell factors are one or more of EGF, PDGF, KGF and 1L-10. The film forming material is chitosan hydrochloride and / or polyvinylpyrrolidone. The solvent is deionized water or distilled water. The wound repair liquid further contains one or more of silver ions, hyaluronic acid and polyglutamic acid. Compared with the prior art, the wound repair liquid is not limited by wounds and the positions where the wounds are located; after the wound repair liquid is sprayed, the film forming speed is high, and no disengagement or breakage is likely to happen; no special smell exists, fewer chemical additives are used, and biocompatibility is good; the spray does not stimulate the wounds or skin, and no allergic reactions or drug resistance is caused; the healing time of the wounds is obviously shortened; after the wounds are healed, film-like matter can be degraded by itself, and formed inflammatory reactions and wound scars are obviously reduced.

The invention relates to a hydrogel dressing, comprising a non-woven fabric layer and a hydrogel layer arranged thereon. The hydrogel is poured on the non-woven fabric and cross-linked by an electron accelerator with an irradiation dose of 15-90 kGy; The hydrogel of the adhesive layer contains water-soluble polymers and monomers and water-soluble chitosan derivatives, the mass percentage of water-soluble polymers and monomers is 15-30%, and the mass percentage of water-soluble chitosan derivatives The percentage content is 0.5-3%; the water-soluble polymer and monomer are one or more of polyvinyl alcohol, hydroxyethyl methacrylate, sodium polyacrylate and gelatin, and the water-soluble chitosan derivative is the shell Polysaccharide hydrochloride. The hydrogel dressing has excellent water absorption performance and good air permeability, and has the functions of antibacterial, anti-inflammatory and promoting wound healing, and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

The invention relates to a composition and a method for preparing modified calcium carbonate and belongs to the field of chemicals. The composition comprises the following components: a polymer, calcium chloride and carbonate, wherein the polymer is any one or more of cationic starch, cationic guar gum, chitosan hydrochloride and 2-hydroxypropyl trimethyl ammonium chloride chitosan; and the carbonate is any one or more of potassium carbonate, sodium carbonate, ammonium carbonate and ammonium bicarbonate. The preparation method comprises the following steps of: (1) preparing aqueous solution of the polymer; (2) adding the calcium chloride into the carbonate; (3) adding the aqueous solution of the polymer into a mixture obtained by the step (2); (4) obtaining calcium carbonate precipitate; and (5) washing and drying the calcium carbonate precipitate. The method has the advantages of simpleness, temperate reaction conditions, and capability of preparing polymer modifier-containing filler and remarkably enhancing filler retention and the like.

The invention discloses a preparation method for efficient anti-bacterial composite hemostatic sponge. The preparation method comprises the following steps: S1, adding sodium chloride and phosphonium salt into a sodium alginate solution to obtain a solution A; S2, adding an emulsifier into dispersion liquid to obtain a solution B, and preparing a 4 to 6 percent calcium chloride solution to serve as a solution C; S3, adding the solution A into the solution B in a water-oil ratio of 1 to (3-7) by an emulsion-crosslinking method, stirring to form an emulsion, adding the solution C into the emulsion for reacting, curing, centrifuging, washing and drying to obtain porous alginate drug-carrying microspheres; S4, dissolving chitosan hydrochloride into water to obtain an aqueous solution, adding the porous alginate drug-carrying microspheres prepared in the step S2 and a hemostatic medicament, performing freeze drying repeatedly, washing and sterilizing to obtain the hemostatic sponge. The hemostatic sponge has high water absorptivity, can rapidly stop bleeding, plug wounds, inhibit wound infection and effectively promote healing of the wounds; the thrombus risk is avoided.

The invention discloses a chitosan derivative quick hemostasis granules and a preparation method thereof. The hemostasis granules are prepared by mixing chitosan hydrochloride, O- carboxymethyl chitosan and auxiliary material with purified water according to a certain proportion, sufficiently stirring and uniformly blending, adding ammonia to adjust the pH value of the mixed liquor to 7.0-9.0, carrying out vacuum filtration, and carrying out aseptic spray drying on the filtrate. The hitosan derivative quick hemostasis granules have the pH value suitable for the body fluid of a human body, haslittle irritation to the skin, can quickly stanch, has the functions of easing pain, promoting wound healing, inhibiting bacteria and the like, and is suitable for various wound hemostasis emergency treatments of trauma haemorrhage, including the hemostasis of large-area haemorrhage. In addition, the preparation method is simple and is easy for scale production.

The invention discloses a chitosan polycation composite material reducing phenols materials in cigarette smoke. The composite material is used for alternatively loading polyanions and hydrophilic polycations on a porous material in a mode of layer-upon-layer self-assembling by using the porous material as a carrier, wherein the hydrophilic polycations which are loaded on the outmost layer of the porous layer are chitosan hydrochloride. The composite material can be used for preparing a cigarette filter, and can also be used for preparing a two-section composite cigarette filter or three-section composite cigarette filter. The invention can reduce phenols harmful substances in the cigarette smoke by using water selectivity in the composite material, and can simultaneously prevent flavor components from losing and keep the internal quality of the cigarette because many flavor organic compounds are not dissolved in water.

The invention relates to a filter tip addition agent for selectively reducing crotonaldehyde in smoke of a cigarette and a preparing method and application thereof. The addition agent is a composite material with polyelectrolyte nano particles loaded on the surface of a porous material. Each polyelectrolyte nano particle is a complex of chitosan hydrochloride and sodium alginate. The mass percentage composition of the polyelectrolyte nano particles in the composite material is 0.1-10.0%. According to a cigarette filter tap prepared through the addition agent, by means of the special structure of loading the nano particles on the porous material of the addition agent and functional groups of the loaded polyelectrolyte nano particles, the release amount of the crotonaldehyde in the smoke of the cigarette can be effectively and selectively reduced. In comparison with a cigarette, sold in the market, of the same specification, the cigarette tip prepared through the composite material enables the release amount of the crotonaldehyde in the smoke of the cigarette to be selectively reduced by 20-70%, fragrance ingredient loss can be avoided, and the inherent quality of the cigarette is kept.

The invention discloses a microbial fertilizer for accelerating crop growth and a preparation method for the microbial fertilizer. The microbial fertilizer comprises the components in parts by mass: 100 parts of plant straws, 8-16 parts of rhamnolipid, 4-10 parts of nucleotide salt, 60-80 parts of chitosan hydrochloride, 0.8-1.2 parts of a bacillus subtilis fungicide, 6-10 parts of lactic acid bacteria powder, 4-8 parts of saccharomycetes powder, 8-20 parts of monopotassium phosphate, 6-10 parts of ferrous sulfate, 10-15 parts of calcium carbonate, 1-3 parts of magnesium chloride, 1-3 parts of ammonium molybdate, 1-3 parts of zinc sulfate, 1-3 parts of manganese sulfate and 1-3 parts of boric acid. The rhamnolipid and the nucleotide salt in the microbial fertilizer have mechanisms of promoting growth and play a synergistic role if being compounded in use, so that the growth promotion to the plant is remarkably improved; in addition, the rhamnolipid further can improve the degradation rate of plant straw fibers by bacillus subtilis with brevibacterium. In addition, the chitosan hydrochloride can degrade plant and animal residues and trace metal elements and convert those into nutrients of plants so as to promote health of the plants.

The invention discloses a bifunctional starch-based composite nanoparticle as well as a preparation method and an application thereof. The preparation method comprises the following steps: hydrolyzingstarch to form linear dextrin, and grading the linear dextrin by adopting an alcohol-alcohol gradient precipitation method to obtain linear dextrin with uniform molecular weight distribution; carrying out oxidation treatment on the linear dextrin through an oxidation system to obtain oxidized dextrin; carrying out complexation reaction on the oxidized dextrin and curcumin to form an oxidized dextrin-curcumin complex, so that the oxidized dextrin-curcumin / chitosan hydrochloride composite nanoparticles and chitosan hydrochloride form the oxidized dextrin-curcumin / chitosan hydrochloride composite nanoparticles. According to the method, the aqueous phase solution of the bifunctional starch-based composite nanoparticles containing the gellan is uniformly mixed with the primary emulsion, the obtained double emulsion is subjected to calcium ion induction treatment to obtain the double emulsion gel, and the double emulsion gel has good oxidation resistance and long-term storage stability andcan be applied to the fields of protection of nutritional ingredients, drug delivery, preparation of cosmetics and the like.

The invention discloses a chitosan polycation additive for reducing phenols in cigarette smoke. The additive is characterized in that the additive takes the granular porous materials as the carrier and hydrophilic polycation materials are loaded on the porous materials; and the hydrophilic polycation is chitosan hydrochloride. When applied to preparing the cigarette filters, the additive can selectively reduce the phenols in the cigarette smoke by utilizing own moisture, at the same time, as most aromatic organic compounds are insoluble in water, the additive can avoid aroma component loss while reducing the phenols in the cigarette smoke and maintain the inner quality of the cigarette.

The invention discloses a liquid band-aid, comprising, active materials, a film-forming material and a solvent. The active materials include cytokines 0.042 to 0.0095%, which are chosen from at least two of EGF (epidermal growth factor), PDGF (platelet derived growth factor), FGF (fibroblast growth factor) and IL-10 (interleukin-10). The film-forming material comprises chitosan hydrochloride 2% to 8%. The solvent is deionized water or distilled water. The invention further discloses a method for preparing the liquid band-aid. By the use of the preparation method and / or the liquid band-aid comprising various biological active materials and prepared by the preparation method, activity of the biological active materials can be retained, and wounds can be efficiently repaired without a scar.

The invention discloses a preparation method of an antibacterial polysaccharide hemostatic cotton based gauze. The method comprises the following steps: firstly, preparing a quaternized polyethyleneimine and a hydroformylation polysaccharide cross-linking agent which have an anti-bacterial function; and then mixing and foaming the quaternized polyethyleneimine, the hydroformylation polysaccharide cross-linking agent and chitosan hydrochloride, uniformly coating the surface of a preprocessed gauze with foaming liquid, and carrying out freeze drying to obtain the antibacterial polysaccharide hemostatic cotton based gauze. After being compounded, polysaccharide hemostatic cotton and the preprocessed gauze are combined closely, do not fall off, have high intensity, and are suitable for compression hemostasis and binding at wounds. Moreover, compared with a common gauze, the antibacterial polysaccharide hemostatic cotton based gauze has the effects of inhibiting growth of microorganisms and inhibiting bacteria when stopping bleeding. In addition, a sponge coating the surface of the gauze uses safe and nontoxic polysaccharide as the cross-linking agent, so that the intensity and the blood stopping effect of the hemostatic cotton based gauze are further improved.

The invention discloses a microorganism fertilizer for promoting crop growth and a preparation method therefor. The microorganism fertilizer comprises the components in parts by weight: 100 parts of plant stalks, 0.08-0.16 part of 5A-hydroxyl laxogenin, 0.04-0.10 part of theobromine, 60-80 parts of chitosan hydrochloride, 0.8-1.2 parts of bacillus subtilis bacterium, 6-10 parts of lactobacillus powder, 4-8 parts of yeast powder, 8-20 parts of potassium dihydrogen phosphate, 6-10 parts of ferrous sulfate, 10-15 parts of calcium carbonate, 1-3 parts of magnesium chloride, 1-3 parts of molybdate, 1-3 parts of zinc sulfate, 1-3 parts of manganese sulfate and 1-3 parts of boric acid. The microorganism fertilizer disclosed by the invention comprises 5A-hydroxyl laxogenin and theobromine, the two components have mechanisms that promote growth, and compound use of the two components can further play synergy, so that the crop growth is significantly improved. In addition, after the chitosan hydrochloride is dissolved into soil, animal and plant residues and trace metal elements are decomposed, thereby transforming into nutrients of plants, improving plant immunity, and promoting plant health.

The invention discloses a temperature-sensitive gel preparation, a preparation method thereof and an application of the temperature-sensitive gel preparation to preventing the transfer of calculus in lithotripsy. The preparation is prepared from the following components by weight percent: 16.5 to 26.5 percent of poloxamer, 1.0 to 3.0 percent of chitosan hydrochloride, 0.5 to 2.5 percent of glycerophosphate, 0.01 to 1 percent of synergistic auxiliary materials, and 67.0 to 81.99 percent of neutral buffer solution. The preparation method is simple, and when used in the lithotripsy, the product has a good effect of preventing the transfer of the calculus, so that the damage risk of the lithotripsy on peripheral tissues can be alleviated; moreover, the product is convenient to wash and high in application value.

The invention discloses a wound disinfecting spraying film agent and a preparation method thereof. The wound disinfecting spraying film agent consists of the following components in percentage by mass: 0.2-0.5% of p-chloro-m-xylenol, 1.5-3.0% of menthol, 1.0-2.3% of camphor, 0.5-1.0% of borneol, 0.5-1.5% of methyl salicylate, 0.25-0.35% of camphor oil, 0.5-1.0% of peppermint oil, 0.1-0.5% of ocimi gratissimi oil, 0.1-0.5% of star anise oil, 0.1-1.0% of eucalyptus oil, 0.1-1.0% of turpentine oil, 3-6% of polyvinylpyrrolidone, 0.1-0.35% of chitosan hydrochloride, 0.1-0.3% of hydroxypropyl methylcellulose, 70-80% of ethanol, 0.5-3% of glycerol and the balance of water. The wound disinfecting spraying film agent provided by the invention has broad-spectrum bactericidal, rapid bactericidal and long-acting antibacterial functions and the like, and the wound disinfecting spraying film agent is rapid to stop bleeding and promote healing; a film can be formed on skin within several minutes so as to isolate bacteria and prevent re-infection of a wound; and in addition, the wound disinfecting spraying film agent is low in irritation of the human skin and is safe and convenient to use.

The invention discloses a rhubarb ultramicro powder-containing film spraying agent for traumatic wounds and a preparation method thereof. Specifically, the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds adopts rhubarb made into ultramicro powder as the raw material, the prepared rhubarb ultramicro powder has a particle size of 75microm or below. The preparation method of the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds includes the following process steps: (1) subjecting rhubarb herb material to preliminary crushing to obtain rhubarb crude powder, then conducting ultramicro pulverization on the rhubarb crude powder to obtain rhubarb ultramicro powder; (2) dissolving chitosan hydrochloride in deionized water, adding a modifier, and performing stirring till complete dissolution; (3) dissolving povidone K30 in anhydrous ethanol, then adding the rhubarb ultramicro powder obtained in step (1), and mixing the substances evenly;and (4) mixing the solution obtained in step (2) and the solution obtained in step (3) to obtain the rhubarb ultramicro powder-containing film spraying agent for traumatic wounds. The rhubarb ultramicro powder-containing film spraying agent for traumatic wounds provided by the invention can effectively treat various skin injured traumas, and has the characteristics of protecting wounds, absorbingwound exuded liquid, promoting tissue repair and regeneration, accelerating wound healing and the like.

The invention relates to a tourmaline / chitosan hydrochloride compound spray-type aqueous dressing and belongs to the technical field of compound aqueous wound dressings. In order to solve the technical problems, the invention provides the compound spray-type aqueous dressing which is suitable for the field of the wound dressings. In the compound spray-type aqueous dressing provided by the invention, chitosan hydrochloride plays a role of blood coagulation and hemostasis, antibiosis antiphlogosis and film formation; tourmaline plays a role of launching far infrared rays, generating negative ions and promoting cell growth and wound healing; and polyvinylpyrrolidone (PVP) in a small number of PVP alcohol solution as an auxiliary material plays a role of a film-forming agent, a dispersing agent and a binding agent. The prepared compound spray-type aqueous dressing is convenient in use, slight in skin irritation and high in film-forming speed, has good effects of antibiosis antiphlogosis and blood coagulation and hemostasis, can be used for launching the far infrared rays, generating the negative ions and promoting the cell growth and the wound healing, is good in air permeability and moisture permeability after the film is formed and can be used as a biological wound dressing.

The invention relates to a veterinary interferon inducer. The veterinary interferon inducer is prepared from the following components: a sodium chloride-phosphate buffer solution with the pH value of 7.2, a 10-80g / L calcium chloride aqueous solution, a 0.1-5g / L chitosan hydrochloride solution, polyinosinic acid and polycytidysic acid. The invention further provides a preparation method of the veterinary interferon inducer. The veterinary interferon inducer provided by the invention is few in side reaction, low in irritation and high in safety, and the preparation method can avoid precipitates generated by calcium chloride and other components.

The invention relates to a polyethylene glycol terephthalate / montmorillonite nano-composites, which includes mass percent 0.5% to 2% organic montmorillonite processed by chitosan hydrochloride. The color in appearance is from reddish to deep red. A film is prepared by hot press the materials, whose limiting viscosity number is between 0.53 and 0.55, vitrification point is between 83 and 85 DEG C, tensile-strength is between 32.0 and 44.0 MPa, and tensile modulus is between 720 and 930 Mpa. The invention aslo discloses its preparation method. The nano-composite includes montmorillonite processed by chitosan hydrochloride, so the lamellar structure arrayed regularly is destroyed, which is distributed evenly in PET matrix in nano-meter and is almost in a removed state. Thereby when additional quantity is a little low, the tensile strength and tensile modulus are greater considerably than pure PET, and the resistance to effect of heat is also improved.

The invention discloses a preparation method for a CMC / FA-chitosan hydrochloride composite nanoparticle. The preparation method comprises the following steps: subjecting carboxymethyl cellulose and ferulic acid to an esterification reaction mediated by 1-ethyl-(3-dimethylaminopropyl)carbodiimide (EDC) under the condition of stirring at room temperature so as to form a carboxymethyl cellulose / ferulic acid complex; preparing a chitosan hydrochloride solution and preparing a carboxymethyl cellulose / ferulic acid complex solution; and subjecting the carboxymethyl cellulose / ferulic acid complex solution and the chitosan hydrochloride solution to a hybrid reaction under stirring to prepare the carboxymethyl cellulose / ferulic acid-chitosan hydrochloride composite nanoparticle. The invention also discloses a method for preparing a Pickering emulsion by using the composite nanoparticle. The composite nanoparticle provided by the invention has good dispersibility and emulsification properties; and the Pickering emulsion prepared by using the composite nanoparticle as an emulsifier has good physical stability and antioxidant activity, and can be widely used in food, medicine, cosmetics, and other fields.

Production of soluble chitose chloride is carried out by mixing chlorhydric acid 6-36wt% with organic solvent in proportion of 1:0-4 into mixed solution, mixing it with chitose powders with deacetylating degree 60-100% in proportion of 1:2.5-1:1, agitating, laying aside at 0-80degree for 0-8hrs, and drying to obtain the final product. It's simple, cheap and efficient; it has gentle reactive condition and friendly environment and can be used in food, medicinal, chemical and agricultural industries.

The present invention provides a biodegradable biopolymer matrix for surgical and / or therapeutic use comprising chitosan hydrochloride and dextran dialdehyde is in the ratio of 1:1 to 1:2. The invention further provides a process for preparing the biopolymer matrix and a kit for a surgical and / or therapeutic use comprising the biopolymer matrix.

The invention provides a preparation method and application of a blueberry anthocyanin chitosan nanoemulsion, and belongs to the field of nanotechnology. The preparation method comprises the following steps: ultrasonically extracting blueberry pomace to obtain a blueberry anthocyanin extracting solvent; freeze-drying; adding a blueberry anthocyanin crude extract to a chitosan hydrochloride solvent with a concentration of 0.5-0.8mg / mL to obtain a mixed solvent I; dropwise adding a carboxymethyl chitosan solvent with the pH of 6.0 plus or minus 0.1 and a concentration of 0.5-2.0mg / mL to the mixed solvent I to obtain a blueberry anthocyanin chitosan nanoemulsion. The blueberry anthocyanin chitosan nanoemulsion prepared by the method can be used for preparing an eye drop and a blueberry anthocyanin beverage. The preparation method provided by the invention is simple, and the average particle size of the prepared blueberry anthocyanin chitosan nanoemulsion is less than 500nm; meanwhile, the loss rate of anthocyanin in the blueberry anthocyanin chitosan nanoemulsion prepared by the invention is extremely small as the storage time prolongs, and the prepared eye drop and beverage have the characteristics of high anthocyanin content, stable property and the like.

The invention discloses a method for synthesizing a ternary-copolymerized super-absorbent resin. The method comprises the following operating steps: weighing chitosan hydrochloride, itaconic acid and acrylic acid according to the mass ratio of (1-11): (2-10): (3-17); firstly, dissolving chitosan hydrochloride and itaconic acid, which are in the mass ratio, into distilled water, and transferring a mixed solution into a four-mouthed flask which is provided with a nitrogen gas conduit and a reflux condensation tube; heating to the temperature of 30-80 DEG C, then, adding a 1%-18% initiator, continuing to react for 1-6 hours under the protection of nitrogen gas, and dropwise adding acrylic acid which is in the mass ratio during reaction; mixing a reactant and ethanol, purifying and baking, thereby obtaining the ternary-copolymerized super-absorbent resin. According to the method disclosed by the invention, the process is simple, and the selected chitosan hydrochloride is a monomer, so that the problem of chitosan solubility is solved, and polymerization reaction can be carried out under neutral conditions; itaconic acid added during the synthesis of the product is a monomer, so that the water absorbency of the product is further improved, the highest absorption volume of deionized water is 1,000-1,100 times, the highest absorption volume of tap water is 300-400 times, and the highest absorption volume of normal saline is 100-120 times.

The invention discloses a photo-crosslinking bionic hydrogel and preparation and application thereof. The monomer of the photo-crosslinking bionic hydrogel is glycidyl methacrylate-citicoline alkalization chitosan hydrochloride. The preparation method comprises the three steps of synthesis of citicoline alkalization chitosan hydrochloride, synthesis of glycidyl methacrylate-citicoline alkalization chitosan hydrochloride and addition of a photoinitiator to obtain the glycidyl methacrylate-citicoline alkalization chitosan hydrochloride hydrogel. The photo-crosslinking bionic hydrogel molding conditions are rapid and mild, a citicoline basic group of a local area branch dual-positive-charge structure can improve hydrophilia, cytotoxicity, antibacterial property and protein adsorption restraining, the obtained bionic hydrogel has the remarkable broad-spectrum antibacterial effect on the physiological environment condition, is non-toxic for normal cells, can restrain protein adsorption, and has the great application value in the biological medical fields of medical treatment, healthcare and the like.

The invention provides water gel woundplast containing American cockroach active ingredients. The water gel woundplast comprises a water gel layer and a high-elasticity base body layer, wherein the water gel layer achieves a healing effect and is in contact with the skin. The water gel woundplast is characterized in that the water gel layer is prepared from the following ingredients in parts by mass: 1 to 3 parts of American cockroach extracts, 1 to 2 parts of bletilla extracts, 1 to 3 parts of chitosan hydrochloride, 1 to 4 parts of polyvinylpyrrolidone K30, 0.05 to 0.1 part of HPMC10W, 0.5 to 1.5 parts of PVA-17880, 1 to 3 parts of glycerol and 20 to 30 parts of pure water. In the contact process of the water gel woundplast with the skin, the water gel layer has the effects of inhibitingbacteria, diminishing swelling, relieving pain and prompting skin healing through the American cockroach extracts and the bletilla extracts; meanwhile, through the chitosan hydrochloride loaded withantibacterial materials with high biocompatibility, the antibacterial and bleeding stopping effects are further improved; the healing time is shortened; the medicine dwell time is prolonged; the wounded surface can better absorb the medicine; the skin tissue restoration is accelerated; the wound healing and regeneration rate is improved; meanwhile, the good waterproof effect and skin-friendly comfort are realized.

The invention relates to a novel ophthalmic curcumin multi-core vesicle gel preparation and a preparation method thereof. The preparation consists of the following medicaments: 0.5 to 2.5 milligrams of curcumin, 5 to 25 milligrams of polyethylene glycol monooleate or polyethylene glycol dioleate, 5 to 25 milligrams of polyethylene glycol monolaurate or polyethylene glycol dilaurate, 5 to 25 milligrams of poloxamer F68, 20 to 200 milligrams of soybean phospholipid or lecithin, and mixed solution of 0.1 to 0.7 mg / L of glycerophosphate solution and 0.01 to 0.05 mg / L of chitosan hydrochloride solution in a volume ratio of 1:1-1:10. By organically combining a multi-core vesicle preparation technology with thermo-sensitive gel, the medicament loading capacity is improved, the bioavailability is also improved, meanwhile, an effect of slow release is achieved, the blank of the ophthalmic curcumin multi-core vesicle gel preparation is filled, and a novel ophthalmic preparation with good treatment effect and low price is provided for clinic.

The invention discloses a compound Chinese herbal medicine disinfectant for tableware and kitchenware disinfection, which consists of the following components in parts by weight: 0.025-0.100 part of common andrographis herb extract, 0.025-0.100 part of flos lonicerae extract, 0.025-0.100 part of radix isatidis extract and 0.032-2.000 parts of chitosan hydrochloride. The disinfectant disclosed by the invention has the advantages that the disinfectant has good killing effect and stability against the pathogenic bacteria of the intestinal tract; acute toxicity tests prove that the compound Chinese herbal medicine disinfectant belongs to practical non-toxic level substances; rat marrow osteocyte micronuclear tests prove that the compound Chinese herbal medicine disinfectant does not have genetic toxicity, has the characteristics of edibility, no toxin, no residue and the like, and can be used safely; the disinfectant realizes a remarkably high killing rate against natural bacteria on marine products, and is particularly suitable for the disinfection in the processing of cold fresh food of marine products.