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Chitosan derivative quick hemostasis granules and preparation method thereof

A technology of chitosan derivatives and hemostatic particles, applied in the fields of biological materials and medical supplies, can solve the problems of not fully realizing the effect of promoting healing and antibacterial properties, not being suitable for wound hemostatic materials, and low interaction between wound sites, etc. Effects of wound healing, reduced production time, ease of production at scale

Inactive Publication Date: 2010-10-20
WUHAN HUMANWELL MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor polarity of chitosan, it is not suitable for direct use as a wound hemostatic material
At present, the technology of making hemostatic materials from chitosan and its derivatives has been disclosed in many patents, but the raw material used in these patents is chitosan itself, because chitosan is insoluble in water, and thus Relatively low wound site interaction to fully realize its healing and antimicrobial properties

Method used

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  • Chitosan derivative quick hemostasis granules and preparation method thereof
  • Chitosan derivative quick hemostasis granules and preparation method thereof
  • Chitosan derivative quick hemostasis granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 1.0kg of chitosan hydrochloride, 1.0kg of O-carboxymethyl chitosan, 0.5kg of glycerin and 0.5kg of propylene glycol as auxiliary materials, mix with 40.0kg of pure water, and use a shear emulsifier to fully stir at 15°C Mix them evenly to obtain a mixed solution. The molecular weight of above-mentioned chitosan hydrochloride is 100,000~500,000, and the deacetylation degree is 82.0%, and the pH value of 1wt% this chitosan hydrochloride aqueous solution is 4.3; The molecular weight of O-carboxymethyl chitosan is 100,000~ 500,000, the degree of deacetylation is 70%, the degree of carboxymethylation is 0.5-0.7, and the degree of substitution of the 6-hydroxyl group is 0.9. After adding ammonia water to the above-mentioned mixed solution to adjust the pH of the mixed solution to 7.0-7.5, put the above-mentioned mixed solution at a pressure of 5×10 5 Vacuum filtration under Pa to obtain the filtrate, and finally send the filtrate into a sterile spray dryer for aseptic s...

Embodiment 2

[0024] Take 0.75kg of chitosan hydrochloride, 0.75kg of O-carboxymethyl chitosan, 0.75kg of glycerin and 0.75kg of propylene glycol as auxiliary materials, mix with 40.0kg of pure water, fully stir to make it evenly mixed, and obtain a mixed solution. The molecular weight of above-mentioned chitosan hydrochloride is 500,000~1,000,000, and the deacetylation degree is 85.0%, and the pH value of 1wt% this chitosan hydrochloride aqueous solution is 4.7; The molecular weight of O-carboxymethyl chitosan is 500,000~ 1,000,000, the degree of deacetylation is 75%, the degree of carboxymethylation is 0.7-0.9, and the degree of substitution of the 6-hydroxyl group is 0.7. After adding ammonia water to the above-mentioned mixed solution to adjust the pH of the mixed solution to 7.6-8.0, the above-mentioned mixed solution was mixed at a pressure of 7×10 5 Vacuum filtration under Pa to obtain the filtrate, and finally send the filtrate into a sterile spray dryer for aseptic spray drying ope...

Embodiment 3

[0026] Take 0.75kg of chitosan hydrochloride, 1.25kg of O-carboxymethyl chitosan, 0.5kg of glycerin and 0.5kg of propylene glycol as auxiliary materials, mix with 40.0kg of pure water, and use a shear emulsifier to fully stir at 20°C Mix them evenly to obtain a mixed solution. The molecular weight of above-mentioned chitosan hydrochloride is 1,000,000~1,500,000, the degree of deacetylation is 87.0%, the pH value of this chitosan hydrochloride aqueous solution of 1wt% is 5.1; The molecular weight of O-carboxymethyl chitosan is 1,000,000 ~1,500,000, the degree of deacetylation is 80%, the degree of carboxymethylation is 0.9-1.2, and the degree of substitution of the 6-hydroxyl group is 0.8. After adding ammonia water to the above-mentioned mixed solution to adjust the pH of the mixed solution to 8.1-8.5, the above-mentioned mixed solution was mixed at a pressure of 5×10 5 Pa~7×10 5 Vacuum filtration under Pa to obtain the filtrate, and finally send the filtrate into a sterile ...

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Abstract

The invention discloses a chitosan derivative quick hemostasis granules and a preparation method thereof. The hemostasis granules are prepared by mixing chitosan hydrochloride, O- carboxymethyl chitosan and auxiliary material with purified water according to a certain proportion, sufficiently stirring and uniformly blending, adding ammonia to adjust the pH value of the mixed liquor to 7.0-9.0, carrying out vacuum filtration, and carrying out aseptic spray drying on the filtrate. The hitosan derivative quick hemostasis granules have the pH value suitable for the body fluid of a human body, haslittle irritation to the skin, can quickly stanch, has the functions of easing pain, promoting wound healing, inhibiting bacteria and the like, and is suitable for various wound hemostasis emergency treatments of trauma haemorrhage, including the hemostasis of large-area haemorrhage. In addition, the preparation method is simple and is easy for scale production.

Description

technical field [0001] The invention relates to a chitosan derivative rapid hemostatic granule with the functions of hemostasis, antibacterial, anti-inflammatory and wound healing and a preparation method thereof, which belongs to the field of medical supplies and also belongs to the field of biological materials. Background technique [0002] The main purpose of wound first aid is to temporarily control bleeding, cover and bandage the wound as soon as possible, isolate the wound from the outside world to reduce the chance of infection, and create good wound conditions for debridement. Traditional wound hemostatic materials are mainly first aid kits, four-head bands, tourniquets and bandages, etc., and sometimes a large number of sterile dressings are used to make up for the deficiency of first aid kits for hemostasis. A large number of sterile dressings are difficult to carry and sterilized to store; first-aid kits and four-head bands only have sterile triangular towels and...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/44A61K31/722A61K9/16A61P7/04
Inventor 陈思全邹伟
Owner WUHAN HUMANWELL MEDICAL SUPPLIES
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