Liquid band-aid and preparing method thereof
A band-aid and liquid technology, applied in medical science, absorbent pads, bandages, etc., can solve the problem of inconvenient wound treatment
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Embodiment 1
[0026] 1. Raw material composition and ratio
[0027] Active substances: EGF, PDGF, FGF, IL-10, and vesicles, of which EGF is 0.002%, PDGF is 0.0005%, FGF is 0.005%, IL-10 is 0.0005%, and vesicles are 14%;
[0028] The solvent is deionized water; the film-forming components include: chitosan hydrochloride accounts for 6%, and polyvinylpyrrolidone accounts for 2%;
[0029] Other components: silver ion 0.05ppm, hyaluronic acid 0.05%, chondroitin sulfate: 5%.
[0030] 2. Preparation method
[0031] (1) Preparation of vesicles
[0032] Collect the serum-free medium of mesenchymal stem cells with low passage number (less than 10 passages) and grow within 48 hours, centrifuge at 500g for 30 minutes at 4°C, and collect the centrifuged supernatant;
[0033] Remove impurities by filtration with 0.22 μm filter membrane, centrifuge at 100,000 g for 70 minutes at 4°C, and remove the supernatant;
[0034] Resuspend the pellet, wash the pellet with PBS, centrifuge at 100,000g at 4°C for...
Embodiment 2
[0043] 1. Raw material composition and ratio
[0044] Active substances: EGF, PDGF, FGF, of which EGF is 0.003%, PDGF is 0.0005%, and FGF is 0.005%;
[0045] The solvent is deionized water;
[0046] The film-forming components include: chitosan hydrochloride accounts for 8%, polyvinylpyrrolidone accounts for 4%;
[0047] Other components: silver ion 0.05ppm, hyaluronic acid 0.1%, chondroitin sulfate: 4%.
[0048] 2. Preparation method
[0049] (1) 8g chitosan hydrochloride is dissolved in 50ml deionized water to obtain chitosan hydrochloride aqueous solution;
[0050] (2) 4g of polyvinylpyrrolidone is dissolved in 20ml of deionized water to obtain an aqueous solution of polyvinylpyrrolidone;
[0051] (3) Mix (1) and (2), mechanically stir and mix at 60°C and 1000rpm. Slow down the stirring speed to 400rpm, reduce and keep the temperature to control the temperature of the mixed solution not to be higher than 37°C. During the stirring process, add 4g chondroitin sulfate, 0....
Embodiment 3
[0055] 1. Raw material composition and ratio
[0056] Active substances: EGF, PDGF, FGF, IL-10, vesicles, of which EGF is 0.003%, PDGF is 0.0005%, FGF is 0.002%, IL-10 is 0.001%, and vesicles are 14.5%;
[0057] The solvent is deionized water;
[0058] Film-forming components: chitosan hydrochloride accounted for 6%, polyvinylpyrrolidone accounted for 0.5%;
[0059] Other components: silver ion 0.05ppm, hyaluronic acid 0.1%, chondroitin sulfate 2%;
[0060] 2. Preparation method
[0061] (1) 6g chitosan hydrochloride is dissolved in 50ml deionized water to obtain chitosan hydrochloride aqueous solution; 0.05g polyvinylpyrrolidone is dissolved in 20ml deionized water to obtain polyvinylpyrrolidone aqueous solution;
[0062] (2) Mix the above two solutions, keep the temperature at 45-60° C., and mechanically stir at 2000 rpm. Reduce the stirring speed to 500rpm, control the temperature of the mixture at 37°C, add 2g chondroitin sulfate, 0.1g hyaluronic acid, 3mgEGF, 0.5mgPDG...
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