825 results about "Cerebral blood vessel" patented technology

Disclosed is an expandable transluminal sheath, for introduction into the body while in a first, small cross-sectional area configuration, and subsequent expansion of at least a part of the distal end of the sheath to a second, enlarged cross-sectional configuration. The sheath is configured for use in the upper vascular system and has utility in the introduction and removal of therapeutic or diagnostic microcatheters. The access route is through the femoral arteries or the iliac arteries to the cerebrovasculature. The distal end of the sheath is maintained in the first, low cross-sectional configuration during advancement to the cerebrovasculature. The distal end of the sheath is subsequently expanded using a radial dilatation device, which is removed prior to the introduction of microcatheters. The sheath can be inserted in a first, small cross-sectional configuration, be expanded diametrically to a second, larger cross-sectional configuration, and then be reduced to a diametrically smaller size for removal.

The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.

The novel amidino derivatives of the formula (I):wherein all the symbols are as in specification defined;have an inhibitory activity of a blood coagulation factor VIIa and are useful for treatment and / or prevention of several angiopathy caused by enhancing a coagulation activity, such as disseminated intravascular coagulation, coronary thrombosis, cerebral infarction, cerebral embolism, transient ischemic attack, cerebrovascular disorders, pulmonary vascular diseases, deep venous thrombosis, peripheral arterial obstruction, thrombosis after artificial vascular transplantation and artificial valve transplantation, post-operative thrombosis, reobstruction and restenosis after coronary artery bypass operation, reobstruction and restenosis after PTCA or PTCR, thrombosis by extracorporeal circulation and procoagulative diseases such as glomerlonephriitis.

The invention provides a synthetic polypeptide of Formula I′:or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

The present invention relates to a method of prevention and treatment of narrowing of cerebral blood vessels after subarachnoid hemorrhage, and in particular, to a method of applying electrical energy through electrical stimulation electrodes particularly positioned in the cervical region of a patient to affect the sympathetic tone of the blood vessels supplying the brain.

The invention discloses a gradual cardiovascular interventional operation robot. The robot comprises a guide wire propulsion module, a balloon catheter propulsion module and a contrast agent injectionmodule, wherein the guide wire propulsion module comprises a guide wire pushing mechanism and a guide wire rotating mechanism, the guide wire pushing mechanism is used for achieving the pushing of aguide wire during a vascular interventional operation, and the guide wire rotating mechanism is used for achieving the rotation of the guide wire during the vascular interventional operation; the balloon catheter propulsion module is used for achieving the pushing of a balloon catheter during the vascular interventional operation, and the contrast agent injection module is used for achieving the injection of a contrast agent during the vascular interventional operation. The gradual cardiovascular interventional operation robot has the advantages that the pushing and rotation of the guide wire,the pushing of the balloon catheter and the injection of the contrast agent can be achieved during the vascular interventional operation, and the guide wire rotating mechanism provides a real-time force feedback function.

A device for protecting cerebral vessels or brain tissue during treatment of a carotid vessel includes a catheter having a distal portion, a proximal portion and a lumen extending therebetween, the catheter including first and second expandable areas for vessel occlusion provided over the length of the catheter. The device further includes an elongate stretching member insertable longitudinally through the lumen of the catheter, the elongate stretching member being configured for stretching at least a portion of the catheter and causing the first and second expandable areas to transition from an expanded state to a collapsed state, and wherein the elongate stretching member is retracted proximally relative to the catheter causes the first and second expandable areas to transition from the collapsed state to a radially, or laterally expanded state.

The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

The invention relates to an opto-acoustic brain function imaging method. The method realizes imaging of brain blood vessel structure distribution observation and function monitoring via the opto-acoustic tomographic image of the cortex blood vessels. Brain damage and cerebral hemorrhage variation degree can be monitored, and the parameters such as cerebral blood flow, brain oxygen consumption and brain oxygen saturation etc can be reflected via the blood vessel form distribution, blood diameter variation and opto-acoustic signal intensity variation of blood vessels. The laser generation component, acoustic signal acquisition component and computer among the devices realizing the mentioned method are electrically connected in turn. The rotary scanning mechanism is electrically connected with the computer. The sample fixation components are connected with the acoustic coupling components in turn. The invention is characterized by convenient operation and sensitive and quick performance, can make imaging analysis of blood vessels without damage, and then monitor brain function, which can thus provide imaging basis for brain function judgment.

The invention provides a synthetic polypeptide of Formula I′:or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

A curcumin medicine for preventing and treating cancer and cardiovascular and cerebrovascular disease includes a pre-concentrated curcumin liquid in the form of softgel and prepared from the precursor of curcumin and emulsifier and a fatty curcumin emulsion prepared from the precursor of curcumin, emulsifier, antioxidant, isotonic regulator, stabilizer, pH regulator, and the water for injection. It can also provide energy to the patient.

Novel cerebral vasculature devices are disclosed, including thrombectomy removal devices that include a continuous braided structure, a proximal portion, a distal portion, and a first expandable portion located between the proximal portion and the distal portion. The braided structure includes a plurality of wires. The proximal portion and the distal portion include polymer imbedded at least partially into the braided structure. The device is useful for removing thrombus from a patient's vasculature.

Disclosed herein is a medical imaging technique that uses a fluorinated nanoparticle contrast agent for imaging of an interior portion of a body. The fluorinated nanoparticles preferably comprise nontargeted intravascular fluorocarbon or perfluorocarbon nanoparticles. The interior body portion may be a patient's vasculature, and the medical imaging is preferably noninvasive MR angiography, which may encompass (either for 2D imaging or 3D imaging) MR coronary angiography, MR carotid angiography, MR peripheral angiography, MR cerebral angiography, MR arterial angiography, and MR venous angiography. Coils tuned to match to the 19F signal can be used, or dual tuned coils for 19F and 1H imaging can be used. Clinical field strengths (e.g. 1.5 T) and clinical doses may be used while still providing effective images.

The invention provides a drink composition containing L-carnitine, plant extracts and water. The plant extracts are selected from barley seedling, barley or fried barley, chrysanthemum, honeysuckle, arabian jasmine flower, tea flower, bamboo leaf flavonoid, eucommia ulmoides male flower, medlar, herba houttuyniae and the like; furthermore, the drink composition also contains inositol, taurine, lysine or lysinate, caffeine, nicotinamide, vitamin B6 and vitamin B12. The invention further provides a preparation method of the drink composition, as well as application of the drink composition in preparation of drinks for supplementing the L-carnitine by oral administration, and burning fat to reduce weight, removing grease and cleansing the palate, clearing away heat and toxic materials, refreshing and relieving summer-heat, refreshing, resisting fatigue, improving appetite and promoting digestion, protecting cardio-cerebral vessels, regulating immunity, resisting fatigue and oxidation, protecting liver and treating fatty liver. According to the novel functional drink containing L-carnitine nutrition and the plant extracts, provided by the invention, the plant extracts and the L-carnitine are matched to realize cooperative nutrient and health functions.

A Chinese medicine in the form of tablet, capsule, particle, or oral liquid for treating cardiovascular and cerebrovascular diseases is prepared from 16 Chinese-medicinal materials including Chuan-xiong rhizome, Chinese angelica root, red peony root, astragalus root, etc. Its preparing process is also disclosed.

The invention discloses a health-care noodle with functions of lowering pressure, blood lipid and sugar and softening blood vessel. The health-care noodle comprises the following materials in parts by weight: 60-80 parts of flour, 4-8 parts of gynostemma pentaphyllum, 3-5 parts of gingko leaves, 2-4 parts of polygonum multiflorum, 3-4 parts of haw, 2-3 parts of chrysanthemum, 1-3 parts of medlar, 5-10 parts of black fungus, 5-10 parts of mushroom and 2-6 parts of onion. The product has excellent improvement effects for patients suffering from hypertension, hyperglycemia and hyperlipoidemia, persons with poor sleep and endocrinopathy and in fatigue state for a long time, heart cerebrovascular sufferers and sub-health persons and better preventive treatment effects for arteriosclerosis, hypertension and coronary heart disease and can enhance disease-resistant abilities. The invention increases new noodle variety and ensures that the traditional noodle is more nutritive without any side effect.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.

An ultrasonic wave radiator suitable for a cerebral infarction therapy apparatus that is attached to indeterminate curvilinear surface of the scalp of a patient under therapy and dissolves thrombus inside a cerebral blood vessel by outputting ultrasonic vibrations of a plurality of frequencies or an ultrasonic vibration having a wide frequency band. The ultrasonic transducer 20 are arranged on one surface of a flexible sheet 11 in a grid configuration or in other configurations and are bonded thereto and a adhesive layer is provided on the other surface of said sheet 11.

The invention discloses an intravascular stent of a composite structure; the intravascular stent comprises a stent main body, wherein the distal end of the stent is restrained as an adducted form by virtue of a tightening wire, and the tightening wire is degradable magnesium alloy or degradable iron alloy; one or more auxiliary wires are woven on the stent main body; when the stent is applied to blood vessel of brain, the auxiliary wire is pure platinum or alloy thereof, pure gold or alloy thereof, pure tungsten or alloy thereof, or pure tantalum or alloy thereof; and when the stent is applied to peripheral blood vessel, the auxiliary wire is cobalt-chromium alloy or stainless steel or tungsten or tantalum. The stent, when serving as a thrombus removal system for treating cerebral apoplexy, not only can be used for removing thrombus effectively for several times but also can be used for catching small thrombus flowing to distal end so as to prevent distal blood vessels from getting blocked; and the stent can be used for dilating stenosis or blocked brain blood vessel or peripheral blood vessel, so as to take an effect of dredging and reconstructing a blood flow. The stent can be repositioned and released, with high controllability; and the stent can be used for reducing operation difficulty and greatly improving an operation success rate.

The invention belongs to the human biological parameter detection and analysis system field, and particularly relates to a brain blood vessel feature and blood flow characteristics analysis system and an analysis method thereof. The analysis system comprises a human biological signal reception part, a main processing part, a control input part, and an output part. Human biological signals collected by the human biological signal reception part are transmitted to the main processing part for data processing after A / D transformation and then are outputted by the output part, and the control input part sends corresponding control signals into the main processing part to complete corresponding data processing. The analysis method comprises: 1) a construction stage of basic data of the brain blood vessel system feature; 2) an evaluation preparation stage of the brain blood vessel system; 3) indirectly working out the elasticity cardinal number of each blood vessel branch displaying feature variance in front, middle and rear brain artery systems. The analysis system and method collects related human biological parameters through a noninvasive measuring method, thereby completing the early diagnosis of human cerebrovascular diseases.

The present invention relates to one kind of plant leavening prepared by using plant with hot and fragrant smell of propylene sulfide, yeast and lactobacillus and through fermentation. The present invention also relates to the preparation process of the leavening and its application is treating presbyopia, cataract and other diseases, promoting blood circulation; improving the functions of sexual organs, kidney, cardiac and cerebral vascular system, digestive system, etc.; resisting oxidation, senility and fatigue; lowering blood fat, blood sugar and blood pressure; etc.

This invention measures cerebral blood volume changes to evaluate, from properties of low-frequency components of such changes and heart rate changes calculated by analysis, a distribution of cerebral blood vessel hardness and its with-time change to thereby estimate and display diseased and dangerous portions based on the evaluation. Briefly, the above-noted object is attainable by a biological measurement system having a cerebral blood volume measurement unit which measures a regional cerebral blood volume of a body under test, an analyzer unit that analyzes a signal measured by the cerebral blood volume measurement unit, an extraction unit for extracting, based on an output of the analysis unit, information concerning a regional cerebral blood vessel state of the test body, and a display unit which displays a measurement result of the cerebral blood volume measurement unit, an analysis result of the analyzer unit or an extraction result of the extraction unit.

A compound comprises a donor and an acceptor, wherein at least one donor ( "D" ) and at least one acceptor ( "A" ) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TPA-TT, PTZ-BT-TPA, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TPA, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound maybe used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.

Embolectomy catheters, rapid exchange microcatheters, systems and methods for removing clots or other obstructive material (e.g., thrombus, thromboemboli, embolic fragments of atherosclerotic plaque, foreign objects, etc.) from blood vessels. This invention is particularly useable for percuatneous removal of thromboemboli or other obstructive matter from small blood vessels of the brain, during an evolving stroke or period of cerebral ischemia. In some embodiments, the embolectomy catheters of this invention are advanceable with or over a guidewire (GW) which has been pre-inserted through or around the clot. Also, in some embodiments, the embolectomy catheters include clot removal devices which are deployable from the catheter after the catheter has been advanced at least partially through the clot. The clot removal device may include a deployable wire nest that is designed to prevent a blood clot from passing therethrough. The delivery catheter may include telescoping inner and outer tubes, with the clot removal device being radially constrained by the outer tube. Retraction of the outer tube removes the constraint on the clot removal device and permits it to expand to its deployed configuration. An infusion guidewire is particularly useful in conjunction with the embolectomy catheter, and permits infusion of medicants or visualization fluids distal to the clot.

The present invention discloses a traditional Chinese medicine preparation for cardio-cerebral blood vessel diseases, it is prepared through extracting danshen and Notoginseng by lye, precipitating with alcohol, concentrating, and adding other medicine and excipients. Then using the HAPLY-MS and HAPLY fingerprint Atlas to characterize its Physicochemical properties completely. Using the fingerprint Atlas analysis method of the present invention, the structure and comparative content of biologically active component can be known. Characterization of the physical chemical properties of danshen and Notoginseng of traditional Chinese medicine preparation with this way is better than other methods of the prior art.

The invention belongs to the technical field of medical image processing and discloses a blood vessel image segmentation method based on centerline extraction and a nuclear magnetic resonance imagingsystem. The method comprises steps of: preprocessing cerebral blood vessel data based on the vesselness filtering of a Hessian matrix; extracting a blood vessel centerline by using a topology refinement method; extracting the features of training samples and test samples by using centerline points as positive samples and non-blood vessel points as negative sample points; by using the feature of the training samples and a corresponding tag training SVM model, using the features of the test samples as the inputs of a trained SVM model and using an output tag as the segmentation method of the blood vessel. The blood vessel image segmentation method reduces workload, improves computational efficiency, requires no manual target calibration or background, fully automatically segments the blood vessel, and greatly improves segmentation efficiency. The blood vessel image segmentation method segments cerebral blood vessels accurately and rapidly without human intervention and can achieve a truepositive rate and a true negative rate as high as 0.85.

The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.

The invention discloses a method for preparing Kushui rose dry red wine, which comprises: intercropping seedlings of China Kushui rose which represents Asian rose fragrance and an imported American red grape variety which can adapt to the northwest district with high elevation, no pollution and big temperature difference between day and night; and after flowering and fruiting, fermenting the red grapes scented by the Kushui rose to obtain dry red wine. The method avoids disrupting the special fragrance and nutrients of rose like the conventional rose wine preparation method adopting a distillation process and also avoids disrupting the special natural fragrance of rose by blending rose and grape juice. Kushui rose contains rich aroma essential oil, tannin, selenium, leucine and over 200 kinds of active substances, and red grapes contain 25 kinds of nutritive elements, such as tannin and vitamin C; therefore, the Kushui rose dry red wine has remarkable effects of softening cardio-cerebral blood vessels of human bodies, activating blood flow, removing blood stasis, activating collaterals, restoring mental clarity and improving immunity.

The present invention relates to a compound medicine for preventing and curing angiocardiopathy and cerebrovascular disease, belonging to the field of chemical medicine. It is characterized by that said compound medicine includes sexual hormones medicine, lipid-reducing medicine, hypotenser, hypoglycemic medicine and anticoagulant medicine. Said compound medicine can be made into various dosage forms. Besides, said compound medicine also can be used for curing the diseases of climacteric syndrome, osteoporosis, endometrial carcinoma, diabetes and metabolic syndrome, etc.