111 results about "Carbohydrate metabolism" patented technology

This invention relates to a nutritional intervention composition for enhancing satiety prior to a meal and extending satiety after a meal. The nutritional intervention composition decreases food intake producing weight loss over time. The composition consists of Niacin, Vitamin B6, Calcium, Phosphorous, Magnesium, Chromium, Chitosan, Fenugreek, Ginseng, White willow bark, Garcinia cambogia, Aloe Vera gel powder, Momordica charantia, Griffonia simplicifolia, Lagerstroemia speciosa and Vanadyl sulfate. The invention does not require stimulants or anabolic ingredients. There are three phases of activity within the composition. One, enhanced satiety through elevated serotonin. Two, improved carbohydrate metabolism, reduced blood glucose and slowed gastric emptying. Three, enhanced fiber binding of lipids and excess bile acids.

A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning. Preferably, the composition of bio-active compounds includes a combination of 4-hydroxyisoleucine with at least one amino acid selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate and tyrosine. In one presently preferred embodiment of the present invention, the combination is derived, isolated, and / or extracted from fenugreek seeds. Methods for using a novel composition of bio-active compounds from fenugreek seed for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning are also disclosed, wherein methods comprise the steps of: (1) providing an effective amount of a composition of bio-active compounds derived, isolated, and / or extracted from fenugreek seeds; and (2) administering the composition to a human or animal.

The invention relates to a beverage and particularly discloses health-care dark tea. The health-care dark tea consists of the following raw materials in parts by weight: 5-8 parts of dark tea, 2 parts of buckwheat, 2-5 parts of lotus leaves, 2-5 parts of sweet potato leaves, 1 part of hawthorn, 3 parts of honeysuckle, 1 part of cassia seed, 1 part of bunge cherry seed, 3-6 parts of pumpkin, 2-4 parts of towel gourd, 2 parts of gingko, 3-5 parts of fructus momordicae, 1 part of mulberry leaf, 1 part of sophora japonica and 2-5 parts of boat-fruited sterculia. The health-care dark tea provided by the invention is easy to prepare and convenient to drink, keeps the warm aroma of dark tea while having the faint scent of the buckwheat and the honeysuckle, is good in taste, and also has a health care function. The dark tea has bactericidal, anti-inflammatory, diuretic, detoxification, anti-oxidation, anti-aging, anti-cancer, mutation-resistant, hypolipidemic, antihypertensive, carbohydrate metabolism improving, hpyerglycemic, and diabetes prevention and treatment functions, and by matching with the functions of promoting digestion and reducing excessive inflation of the hawthorn and the heat-clearing and detoxicating functions of the honeysuckle, the health care effect of the dark tea is remarkable.

The present invention relates to a process for preparing chiral non-racemic cis-configured cyclohexanols or cyclohexanol derivatives of the formula (I) Cis-configured hydroxyl-cyclohexane carboxylic acid derivatives of formula (I) are central building blocks or immediate precursors for the medicinally active compounds which allow a therapeutic modulation of the lipid and / or carbohydrate metabolism and are thus suitable for preventing and / or treating type II diabetes, hyperglycemia and artherosclerosis. The cis-configured hydroxyl-cyclohexane carboxylic acid derivatives of formula (I) are central building blocks or immediate precursors for the medicinally active compounds described in the prior art.

A method of infusing liquid medicaments including insulin via an insulin pump, includes identifying an insulin delivery protocol associated with ingestion of carbohydrates wherein the insulin delivery protocol is likely to lead to a postprandial drop in blood glucose to a level below a basal level, then proposing at least one alternative insulin delivery protocol to inhibit the postprandial drop in blood glucose by delivering a metered amount of insulin that is appropriate to facilitate the metabolism of the carbohydrates without the postprandial blood glucose level drop. The invention further includes querying the patient as to whether to apply the alternative insulin delivery protocol, receiving instructions from the patient in response to the query, and applying the alternative insulin delivery protocol following receiving instructions from the patient to apply the alternative insulin delivery protocol.

The invention relates to an oral glucose liquid composition and a preparation method thereof. The composition is prepared from maltodextrin, fructose, citric acid, sodium citrate, potassium citrate, a sweetening agent, a food flavor and a proper amount of purified water, and is mainly used for being orally taken by a patient suffering from perioperative management before an operation. The oral glucose liquid composition is capable of changing the energy storage under a limosis condition of the patient and keeping the carbohydrate metabolism, reducing the postoperative insulin resistance, alleviating preoperative thirst, hunger and anxiety, improving the postoperation subjective symptom of the patient so as to improve consciousness, reducing the body weight loss of emaciated patients, and shortening the hospitalization time.

The present invention has utilized the power of lipidomics to profile lipid metabolites and to characterize changes in lipid metabolism as they relate to CNS disorders. Lipidomic signatures can guide the development of diagnostic, prognostic and surrogate markers for CNS disorders; identification of new targets for drug design based on highlighted perturbed pathways; stratify patients with CNS disorders as to which pathways are impaired, and facilitate the determination of which patients with CNS disorders are candidates for a particular therapy, i.e. provide the tools for a personalized approach to therapy; identify which patients are responding or are developing side effects to a treatment; design of modified antipsychotics that have less metabolic side effects and enhanced activity; overcome the lag phase in response to some treatments; and find better combination therapies for CNS disorders that target the pathways that are impaired (e.g., impairments in lipid and / or carbohydrate metabolism).

The invention relates to novel heterocyclic compounds having the structure illustrated by Formula (I) wherein the Ar1 radicals are substituted dihydronapthalene or isochroman radicals, the Ar2 radicals are aryl or heteroaryl radicals; and HAr is a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one radical. The compounds of Formula (I) can have biological activity for advantageously regulating carbohydrate metabolism, including serum glucose level, and lipid metabolism, and can be useful for the treatment of hyperlipidemia and / or hypercholesterolemia, and Type II diabetes. The compounds of Formula (I) can also have utility in the treatment of diseases of uncontrolled proliferation, including cancer.

The invention belongs to the field of biological medicines, relates to novel uses of artemether and artemisinin analogues in pharmacy, particularly relates to uses of artemether in preparation of preparations promoting steatolysis and improving carbohydrate metabolism, and more particularly relates to uses of artemether and artemisinin analogues in preparation of preparations promoting browning of white adipose and preparations reducing body weight and improving metabolism. In-vivo and in-vitro experiments prove that the artemisinin analogues have a function of inducing browning of white adipose, and through promoting the browning of white adipose, effects of reducing body weight, improving metabolism, maintaining a carbohydrate metabolism steady state, relieving fatty liver and improving diabetes related symptoms are achieved. Clinical application practices show that intolerable adverse effects of the artemisinin analogues have not been found, the artemisinin analogues can be further prepared into preparations promoting steatolysis and improving carbohydrate metabolism and the preparations are used for treating and improving metabolism related diseases.

Nutritional compositions in a dry powder, bar, and gel form including a 2:1 ratio of maltodextrin to fructose and one or more proteins. Further compositions include maltodextrin, fructose, whey protein, and a standardized amount of an extract selected from the group consisting of green tea, pomegranate, and mangosteen. Having the carbohydrates and one or more proteins present in a 12:1 ratio also has been found to be desirable. The addition of select vitamins and electrolytes further aid in carbohydrate metabolism and general hydration.

A method is described for the treatment of obesity or other disorders, by electrical activation or inhibition of the sympathetic nervous system. This activation or inhibition can be accomplished by electrically stimulating the greater splanchnic nerve or other portion of the sympathetic nervous system using an implantable pulse generator. This nerve activation can result in reduced food intake and increased energy expenditure. Reduced food intake may occur through a variety of mechanisms that reduce appetite and cause satiety. Increased adrenal gland hormone levels will result in increased energy expenditure. Fat and carbohydrate metabolism, which are also increased by sympathetic nerve activation, will accompany the increased energy expenditure.

The invention discloses a nutritional congee product, and particularly relates to five-grain fiber congee; and meanwhile, the invention also discloses a method for preparing the five-grain fiber congee. The glutinous rice is warm-natured and sweet, and has an efficacy of reinforcing middle-jiao and replenishing qi; the soybean is known as 'the king of beans', and also called as 'vegetable meat' and 'green dairy cow'; and the corn has the functions of regulating the center and whetting the appetite, benefiting lung and calming the mind, clearing damp-heat, benefiting liver and gall, delaying senescence, and the like. Xylitol is an intermediate of carbohydrate metabolism of a human body, under the condition that the glycometabolism is affected because the human body is short of insulin, without the promotion of insulin, the xylitol also can translocate across cell membranes and then is absorbed and used by tissues so as to supply nutrition and energy for cells without causing blood glucose level increasing, thereby eliminating the occurrence of three-increase symptoms (polyphagia, polydipsia and polyuria) of patients with diabetes after the congee is taken, so that the five-grain fiber congee is a nutritional sugar substitute which is most suitable to be eaten by patients with diabetes. In five-grain fiber, the sucrose is replaced by the xylitol, therefore, the five-grain fiber congee is a preferred congee product of patients with diabetes and fat-reducing people.

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

The invention provides a compound maltodextrin fructose beverage. Each liter of compound maltodextrin fructose beverage comprises, by weight, 100-110 g of maltodextrin, 10-20 g of crystalline fructose, 2.0-3.0 g of sodium citrate, 3.0-4.0 g of potassium citrate, 0.1-0.2 g of sweetening agent, 0.2-0.3 g of vitamin C, pH modifier, and the balance water, wherein the dosage of the pH modifier follows the standard of making the pH of the compound maltodextrin fructose beverage be 4.7-5.0. The compound maltodextrin fructose beverage contains carbohydrates and vitamin C, the energy of the beverage is high, and the beverage is rich in nutrition. The invention further provides a method for preparing the compound maltodextrin fructose beverage. The preparation method is simple and easy to operate. The compound maltodextrin fructose beverage is suitable for being drunk by a patient before an operation, so that the patient's energy storage under the conditions of an empty stomach is improved, the carbohydrate metabolism is maintained, postoperation insulin resistance is reduced, pre-operation thirst, hunger and anxiety are relieved, the patient's postoperation subjective symptom improvement awareness is improved, the thin and weak patient's weight loss is reduced, and hospital stay is shortened.

The present invention relates to certain substituted heterocycles of Formula (200),wherein B, H, I, J and K together with the Ar5 form a ring containing at least one amide residue, and W, X, Y and Z together form a 2,4-thiazolidinedione, 2-thioxo-thiazolidine-4-one, 2,4-imidazolidinedione or 2-thioxo-imidazolidine-4-one residue; or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of diseases such as type 2 diabetes, and related disorders of lipid and carbohydrate metabolism, including atherosclerosis. The compounds are also useful for treating diseases of uncontrolled proliferation, such as cancers in general, including breast cancer.

The invention discloses an application of fucoidan in preparation of intestinal prebiotics. The fucoidan has the functions of promoting carbohydrate metabolism, biosynthesis and metabolism of sugar, reducing membrane transport function, enhancing digestive system function or reducing disease infection, promoting production of short-chain fatty acids in intestinal tracts, improving intestinal microbial flora level. The fucoidan is used for preparing intestinal prebiotics, is used for human bodies or livestock and poultry animals, and has a wide application prospect.

The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.

Compositions and methods for modulating flowering, plant height, sugar metabolism and stress response in plants are provided.

Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and / or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.

A noninvasive method for diagnosing skin health in a subject comprising collecting a skin sample from the subject; detecting a level of one or more small molecule biomarkers in the epithelial cell sample / skin cell sample; diagnosing the subject as having a skin condition based on the level of a detected small molecule biomarker, wherein the detected small molecule is at least one compound chosen from: a compound generated by metabolism of amino acids, a compound generated by dipeptides metabolism, a compound generated by nucleic acids, a compound generated by metabolism of lipids, a compound generated by metabolism of carbohydrates, and mixtures thereof and further small molecule biomarkers as listed in Table 1. Further, a noninvasive method for evaluating the efficacy of products for skin health.

Compositions and methods for modulating flowering, sugar metabolism and stress response in plants are provided.

The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.

The invention discloses an Apio americana medikus leaf flavone extract, a preparation method and applications thereof, wherein the Apio americana medikus leaf flavone extract contains 78-87% by mass of total flavonoids, the total flavonoids contain vitexin and schaftoside, and by using the Apio americana medikus leaf flavone extract as the reference, the mass fraction of the vitexin is 45-50%, and the mass fraction of the schaftoside is 19-24%. According to the present invention, by using the Apio americana medikus leaf as the object to extract the flavone substances, the obtained Apio americana medikus leaf flavone extract is rich in flavones, especially vitexin and schaftoside, can effectively inhibit the activity of alpha-glucosidase, can promote the carbohydrate metabolism of cells, and has blood glucose lowering activity.

A solid oral diagnostic test meal is provided that contains a polysaccharide, wherein the oral diagnostic test meal provides a medically controlled quantity of glycemic carbohydrate after being ingested by a vertebrate subject. In addition, methods and kits are provided for using the diagnostic test meal to monitor postprandial glucose to screen insulin levels and / or diagnose disorders of carbohydrate metabolism, to manage subjects being treated with antidiabetic agents, to self-diagnose diabetes and self-manage diet and antidiabetic drug dosage, and to calculate the glycemic index of a test food.

The invention discloses a Chinese medicinal compound external preparation for treating diabetes and a preparation method and application thereof. The Chinese medicinal compound external preparation comprises the following raw materials in part by weight: 5 to 15 parts of raw rhubarb, 5 to 15 parts of amur corktree bark, 3 to 10 parts of golden thread, 10 to 50 parts of lightyellow sophora root, 10 to 30 parts of honeysuckle flower, 5 to 15 parts of frankincense, 5 to 15 parts of myrrh and 10 to 30 parts of common bletilla pseudobulb. The Chinese medicinal compound external preparation provided by the invention is prepared by proportioning traditional Chinese medicines by using the syndrome differentiation and treatment theory according to the Chinese medicine theory; an experiment result shows that the Chinese medicinal compound external preparation provided by the invention can effectively correct disturbance of carbohydrate metabolism, reduce blood sugar level, improve the function of pancreatic B cells and improve insulin resistance; and the experiment result shows that the Chinese medicinal compound external preparation provided by the invention has good effects of resisting inflammation and promoting wound healing, can effectively prevent and treat complications of the diabetes, can be prepared into formulations conveniently, such as spray, cleaning solution and the like, and has the advantages of convenient clinical use and safety.

The present invention is directed to cosmetic and / or pharmaceutical compositions comprising at least one plant lipid, having as its main application the treatment of keratinous materials, particularly skin, hair, scalp, nails and eyelashes, by modulating the expression of genes responsible for ROS metabolism, lipid metabolism, skin integrity, cell renewal, cell differentiation, strengthening the skin barrier, calcium metabolism, cell proliferation, tissue healing and / or repair, cell adhesion, carbohydrate metabolism, hydration, skin homeostasis / maintenance, skin defense and / or protection, remodeling and / or extracellular matrix synthesis, skin peeling, tissue maintenance, cell signaling, normal development of the epidermis, epidermal barrier function, development of the skin, dermis-epidermis junction, anti-inflammatory or antioxidant action in keratinous materials, through the modulation of the expression of the genes involved in said functions. The present invention also teaches methods of modulating the expression of genes responsible for such functions of keratinous materials and the use of said plant lipids in the preparation of said compositions.

Methods are provided for regulating fat storage, carbohydrate metabolism and fatty acid synthesis using modulators of membrane type matrix metalloproteinase 1 (MT1-MMP).

Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin signaling, lipid metabolism, extracellular matrix (ECM)-receptor interaction, or combinations thereof, methods of treating hyperlipidemia, obesity, excessive cholesterol, cardiovascular disease, liver disease, diabetes, or combinations thereof, and methods of stimulating glucose uptake in an animal in need thereof, comprising administering a composition comprising at least one isolated glyceollin to said animal.

The invention discloses a method for preventing rice stifle or runt seedling, which is characterized in that: a zinc fertilizer is applied in the growth period of rice by using common methods, such as base fertilizer application, top application, leaf spray, seed soaking and seed dressing. The method can promote the breath and carbohydrate metabolism of the somatic cell of rice effectively, increase the utilization rate of oxygen, prevents rice stifle or runt seedling and realize yield and income.