80 results about "Blood Circulation Time" patented technology

The invention relates to portable albumin binders, which are useful for improving the pharmacokinetic properties of diagnostic or therapeutic agents, in particular increasing the blood circulations time and / or the tissue penetration capacity of such agents.

Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA- containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid / PEG- lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.

The invention relates to multifunctional gold and silver core-shell nanoparticles. The gold nanopartciles are covered by silver nano shell layers and the nanoparticles with silver core shell structures are conducted for surface modification through sulfydryl polyethylene glycol molecules; and gold nano core particles are 3 to 20 nm in size, and silver nano shells are 2 to 12 nm in size. Especially, the gold and silver core-shell nanoparticles covered by the silver nano core and shells are prepared by reducing chloroauric acid to prepare ultrafine fold nanopartciles through tetrakisphosphonium chloride activated by alkaline liquor as a reducing agent, and reducing a silver nitrate solution by nanoparticles as crystal nucleuses; and a CT (Computed Tomography) contrast medium with long-efficiency blood circulation time and an anti-infective function is obtained by performing surface modification for the gold and silver core-shell nanoparticles through polyethylene glycol modified by tail sulfhydrylation. The multifunctional gold and silver core-shell nanoparticles are uniform in particle size, good in water solubility, and free from obvious agglomeration, and the core-shell nanoparticles have stronger dissipation capacities on X rays, thereby being superior to effective developing time of CT of traditional contrast medium ioversol; and the core-shell nanoparticles effectively inhibit infection of bacteria through a contrast medium injection window.

The invention discloses antitumor platinum drug mineralization protein nanoparticles and a preparation method and application thereof. The antitumor platinum drug mineralization protein nanoparticlesand the preparation method thereof have the advantages that the platinum drug mineralization protein nanoparticles are successfully prepared through the two-step preparation method for the first time,the prepared nanoparticles can be uniformly dispersed in an aqueous solution, the nanoparticles has good cytotoxicity, and the IC50 of the nanoparticles to human non-small-cell lung cancer cells A549is 6.9 microgram / ml; the platinum drug mineralization protein nanoparticles comprising a platinum drug and protein are simple in preparation process, uniform in size, controllable in particle size, good in biocompatibility, good in water solubility, long in blood circulation time, high in tumor targeting performance and capable of laying a foundation for efficient tumor treatment or drug-resistant tumor treatment.

Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid / PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor.

The invention provides a polymer shown as formula (I) in the description and a preparation method of the polymer. The prepared polymer has narrower polydispersity index. The invention further discloses a polymer-antitumor drug conjugate and a preparation method thereof. The prepared polymer-antitumor drug conjugate has longer blood circulation time and can obtain more drug accumulation at a tumorpart, so that a drug has better antitumor effect and has broad market application prospects.

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have been already used as building blocks in polymer drug conjugates and polymeric micelles. Those systems have been applied to various medical applications ranging from therapy to molecular imaging. Furthermore a polyglutamic acid (PGA) paclitaxel conjugate has already entered clinical studies (Opaxio™ PGA-PTX conjugate currently in phase III of Clinical trials).In this context, a synthetic pathway to a plethora functional polyglutamates (homopolymers, block-co-polymers, tribocks) with well-defined structure, adjustable molecular weight (Mw) and low dispersity (D=Mw / Mn<1.2) applying the ring opening polymerization (ROP) of N-carboxyanhydrides (NCA) has been developed. Additionally, the acid moieties of the polyglutamates can be activated with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium (DMTMM) and various functionalities can be easily introduced by “post-polymerization modification” yielding a set orthogonal reactive attachment sides. The reactive moieties, such as azides, maleimides, thiols, akynes (linear or cyclic) offer the opportunity of specific conjugation of the drugs, targeting moieties or markers. Besides introducing reactive groups the functionalization strategy was also used for PEGylation of PGA reducing charge induced interactions and therefore pharmacological properties, such as blood circulation time may be adjusted.In summary, a tool kit of various polyglutamates has been developed enabling the synthesis of a variety of polymer drug conjugates or polymer based imaging agents. The functional polymeric precursors developed will allow us to functionalize and therefore adjust the polymer properties to a desired application.

The invention relates to a preparation method of a G2.NH2 based manganese-based MR / CT (Magnetic Resonance / Computerized Tomography) dual-mode imaging contrast agent with an RGD (arginine-glycine-aspartic acid) targeting function. The preparation method comprises the following steps: mixing G2.NH2 and NOTA and reacting to obtain G2-NOTA; then mixing COOH-PEG-MAL and RGD and reacting to obtain COOH-PEG-RGD; after carrying out activation treatment, reacting with the G2-NOTA to obtain G2-NOTA-PEG-RGD; reacting with a chloroauric acid solution and a pre-cooled sodium borohydride solution to obtain G2-NOTA-PEG-RGD@Au; mixing G2-NOTA-PEG-RGD@Au with MnSO4 and reacting to obtain a product. The MR / CT contrast agent prepared by the preparation method has good colloid stability, excellent biocompatibility, relatively long blood circulation time and relatively high relaxation rate; the MR / CT contrast agent has a specific targeting effect on in-situ brain glioma of a mouse and a good thought is provided for developing a novel dual-mode nano contrast agent.

The present invention relates to a quercetin long-acting liposome powder injection and its preparation method. Said powder injection is formed from quercetin, polyethylene glycol-ethanolamine phosphoglycerides, lecithin, cholesterol and excipient. Said invention also provides the concrete steps of its preparation method.

The invention discloses a gadolinium coordination polymer network microsphere and application thereof to magnetic resonance imaging and belongs to the field of material science and biomedical application. The coordination polymer network microsphere is of a net-shaped crosslinking structure; specifically, after an acrylic monomer is coordinated with gadolinium ions, the net-shaped cross-linked gadolinium coordination polymer network microsphere is formed through coordination and free radical polymerization. A preparation method of the polymer microsphere is simple and the cost is low; the polymer microsphere has a stable structure and has a relatively high relaxation rate, a relatively good T1 imaging effect and long blood circulation time; the polymer microsphere has extremely great potential application value in the aspects of diagnosis and treatment of cancers and tumors.