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Multifunctional gold and silver core-shell nanoparticles and preparation method

A gold-silver core-shell and nanoparticle technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, antibacterial drugs, etc., can solve the problems of poor prognosis, achieve broad-spectrum antibacterial ability, react without energy consumption, and inhibit the damage to the body. Effect of infection

Inactive Publication Date: 2013-02-06
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the above-mentioned studies have overlooked a problem. Injection is the most commonly used method of contrast agent intervention in clinical practice, and it is inevitable to leave wounds. Statistics have found that pathogen infection at the wound or wound site is the most important pathogenic route of antibiotic-resistant bacteria. , taking methicillin-resistant Staphylococcus aureus as an example, infected patients often show strong tolerance to first-line and some second-line antibiotics, conventional treatment is usually ineffective for it, and the prognosis is poor, while both anti-infection and CT contrast agents with X-ray attenuation ability have not been reported yet

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  • Multifunctional gold and silver core-shell nanoparticles and preparation method
  • Multifunctional gold and silver core-shell nanoparticles and preparation method
  • Multifunctional gold and silver core-shell nanoparticles and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Measure 20uL tetrakishydroxymethylphosphorus chloride solution, add 20mL 0.05mol / L potassium hydroxide aqueous solution to activate, prepare organophosphorus precursor solution with reducing activity, stir for 5min and then stand still for use.

[0025] Quickly add 50 μL of 0.01mol / L chloroauric acid solution into the above-mentioned reducing organophosphorus precursor solution, and react for 10 minutes under stirring conditions, then add 200 μL of 0.01mol / L silver nitrate solution, and then continue stirring for 2 hours. The solution was purified by centrifugation, the supernatant was discarded, the product was re-dispersed in deionized water after de-washing, and the above-mentioned washing and re-dispersing process was repeated at least three times to finally obtain a purified product, which was re-dispersed in absolute ethanol to obtain brown-yellow gold and silver The core-shell nanoparticle sol has an average particle size of 15nm, wherein the size of the gold nano...

Embodiment 2

[0027] Measure 30uL tetrakishydroxymethylphosphorus chloride solution, add 30mL 0.07mol / L sodium hydroxide aqueous solution to activate, and prepare organophosphorus precursor solution with reductive activity, stir for 10min and let it stand for use.

[0028]Quickly add 100 μL 0.05mol / L chloroauric acid solution into the above-mentioned reducing organophosphorus precursor solution, and react for 20 minutes under stirring conditions, then add 150 μL 0.05mol / L silver nitrate solution, and then continue to stir for 1.5 hours. The solution was purified by centrifugation, the supernatant was discarded, the product was re-dispersed in deionized water after de-washing, and the above-mentioned washing and re-dispersing process was repeated at least three times to finally obtain a purified product, which was re-dispersed in absolute ethanol to obtain reddish-brown gold and silver The core-shell structure nanoparticle sol was analyzed by ultraviolet-visible light absorption spectrum. The...

Embodiment 3

[0030] Measure 40 μL of tetrakis hydroxymethyl phosphorus chloride solution, add 50 mL of 0.45 mol / L potassium hydroxide aqueous solution to activate, prepare the organophosphorus precursor solution with reductive activity, stir for 20 min, and let it stand for use.

[0031] Quickly add 200 μL 0.08mol / L chloroauric acid solution into the above-mentioned reducing organophosphorus precursor solution, and react for 8 minutes under stirring conditions, then add 300 μL 0.08mol / L silver nitrate solution, and then continue to stir for 1 hour. The solution is purified by centrifugation, the supernatant is discarded, the product is re-dispersed in deionized water after de-washing, and the above-mentioned washing and re-dispersing process is repeated at least three times to finally obtain a purified product, which is re-dispersed in absolute ethanol to obtain orange-yellow gold and silver cores The shell-structured nanoparticle sol is analyzed by X-ray photoelectron spectroscopy for its ...

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Abstract

The invention relates to multifunctional gold and silver core-shell nanoparticles. The gold nanopartciles are covered by silver nano shell layers and the nanoparticles with silver core shell structures are conducted for surface modification through sulfydryl polyethylene glycol molecules; and gold nano core particles are 3 to 20 nm in size, and silver nano shells are 2 to 12 nm in size. Especially, the gold and silver core-shell nanoparticles covered by the silver nano core and shells are prepared by reducing chloroauric acid to prepare ultrafine fold nanopartciles through tetrakisphosphonium chloride activated by alkaline liquor as a reducing agent, and reducing a silver nitrate solution by nanoparticles as crystal nucleuses; and a CT (Computed Tomography) contrast medium with long-efficiency blood circulation time and an anti-infective function is obtained by performing surface modification for the gold and silver core-shell nanoparticles through polyethylene glycol modified by tail sulfhydrylation. The multifunctional gold and silver core-shell nanoparticles are uniform in particle size, good in water solubility, and free from obvious agglomeration, and the core-shell nanoparticles have stronger dissipation capacities on X rays, thereby being superior to effective developing time of CT of traditional contrast medium ioversol; and the core-shell nanoparticles effectively inhibit infection of bacteria through a contrast medium injection window.

Description

technical field [0001] The invention relates to the field of preparation of nanoparticles, in particular to an in-situ preparation method of gold-silver core-shell nanoparticles with anti-infection ability and CT imaging function. Background technique [0002] The rapid development of modern radiographic imaging technology has made the early diagnosis of many diseases (such as malignant tumors and atherosclerosis) difficult to cure by traditional medicine possible. Among them, Computed Tomography (CT) The imaging time is short (less than 10s) and the spatial resolution is high (minimum 0.5mm). Compared with magnetic resonance imaging, it can effectively reduce the impact of motion artifacts on data acquisition while ensuring image accuracy. However, due to the small difference in the X-ray dissipation capacity of human tissue and blood, the low degree of discrimination between the lesion and the surrounding normal matrix makes it difficult to effectively identify the lesion ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06A61P31/04
Inventor 胡勇霍达赵慧玥周航周艺周正扬何健
Owner NANJING UNIV
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