46 results about "6-gingerol" patented technology

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

An aspect of the present invention relates to compositions comprising a gingerol, for example, compositions comprising gingerol in an amount greater than about 2% by weight. In some aspects of the invention, the composition comprises 6-gingerol, 8-gingerol, 10-gingerol, 6-shagaol, or combinations thereof. Another aspect of the invention relates to a method for extracting a ginger species comprising, sequentially extracting a ginger species plant material to yield an essential oil fraction, a gingerol fraction, a phenolic fraction, and a polysaccharide fraction, wherein the essential oil and gingerol fractions are derived by extracting plant feedstock material by supercritical carbon dioxide extraction, the phenolic fraction is extracted from the plant feedstock material or from the remainder of the essential oil and gingerol extractions by hydroalcoholic extraction, and the polysaccharide fraction is derived by water extraction of the remainder of the phenolic extraction.

The invention discloses a separating method of 6-gingerol, which is characterized by the following: adopting multiple chromatographic ways to separate effective component 6-gingerol in the traditional Chinese medicine ginger; accelerating the separating course; simplifying the operation; improving the quality and production.

The invention relates to a biochemical engineering separating method of natural active products, and especially relates to a method for simultaneously extracting and separating ginger essential oil and ginger oil resin enriched in gingerol in ginger by a supercritical carbon dioxide fluid. The method is characterized in that the pressure and temperature of an extraction kettle is changed, the ginger essential oil containing little 6-gingerol and 6-gingerol-enriched ginger oil resin with large appearance and property difference can be obtained in a separation kettle in different extraction and separation phases. The method uses a separation kettle, the process flow is simple, two important extraction products such as ginger essential oil and ginger oil resin in ginger can be used in the fields of food, cosmetic, medicine and the like and clearly obtained at a time, the investment for equipments and workshops is small, and the large scale production can be carried out.

The present invention relates to a method that can be used for qualitatively determing 6-gingeroloxime formed by means of oxime-removing reaction of 6-gingeroloxime and uses 6-gingeroloxime as internal standard of determination to determine gingerol content in fresh ginger and its products.

The invention discloses a method for continuously extracting and purifying ginger polyphenol. According to the method, firstly, the ginger polyphenol is extracted in a combined way by an enzyme-ultrasound method; after the purification by an ultra-pure method, AB-8 macroporous resin adsorption is performed; then, a polyamide column, a silicon gel column and a Sephadex LH-20 gel column are continuously used for chromatography purification; the sample is subjected to freeze drying to obtain a purified sample. The maximum absorption wavelength of the polyphenol obtained from the ginger polyphenolpurified sample prepared by the method through UV scanning and CG-MS analysis is 281 nm; the result of the CG-MS analysis proves that the purified materials mainly contains 66.38 percent of 6-gingerol, 3.12 percent of 8-gingerol, 2.06 percent of Z-6-shogaol, 1.93 percent of 8-shogaol, 2.53 percent of citral and 9.35 percent of capraldehyde (heating degrading products of shogaol). The purity of the ginger polyphenol prepared by the method is as high as 85.37 percent.

The invention relates to a natural composite antioxidant and an antioxidant method thereof for inhibiting marine fish lipid oxidation. The natural composite antioxidant is prepared by dissolving 6-gingerol, apple polyphenol, a purple bellis perennis extract and chitosan in glacial acetic acid, and stirring the materials evenly. The antioxidant method includes: dipping marine fish slices in the natural composite antioxidant, then taking the slices out and conducting draining, loading the slices into a polyethylene bag and performing sealing, then storing the product at 4+/-1DEG C. The method can significantly retard lipid oxidation of marine fish slices. All components of the natural composite antioxidant provided by the invention are natural products, have synergistic effect, and are safe, efficient, and free of toxic and side effect. The method is easy to operate, and is widely applicable to preservation and freshness keeping of various marine fish.

The invention discloses a method for simultaneously detecting the content of four components in Huangqi Guizhi Wuwu Granule. The four components are paeoniflorin, calycosin-7-glucoside, cinnamaldehydeand 6-gingerol. The method comprises the steps of extracting a to-be-detected sample by using an extraction solvent: 30-80% methanol, filtering extract and directly detecting by using a high-performance liquid chromatograph. Through the method disclosed by the invention, the content of the four components in the Huangzhi Guizhi Wuwu Granule can be simultaneously detected and the method has the advantages of high efficiency and accuracy and the like, so that the quality of the Huangqi Guizhi Wuwu Granule is more controllable.

The invention belongs to the technical field of chemical engineering, and particularly relates to a separating and extracting method for 6-gingerol in fresh ginger. The silica gel column chromatography ascending development method is used so that 6-gingerol can be individually separated from a silica gel chromatography column in quantity. The problem that due to the fact that 6-gingerol is easy to decompose when heated, 6-gingerol is difficult to separate is solved. The purity of 6-gingerol obtained through the method is 85% or more. Meanwhile, the method is convenient, fast, low in cost, easy to implement and suitable for large-scale application and popularization.

The invention relates to a natural medicine composition used for treating cardiovascular diseases. The natural medicine composition comprises aconitine, liquiritin and 6-gingerol and is prepared into oral preparations, such as hard capsules, soft capsules, tablets, granules, powder, pills, tea bags and medicinal liquor by utilizing synergistic effects of the components. The composition can achieve the effects of treating rats with heart failures caused by myocardial infarction, increasing the ejection fractions and fractional shortening of the rats, obviously improving cardiomyocyte morphologies, reducing the degree of cardiac collagen fibrosis and reducing the contents of aldosterone and atrial natriuretic peptide in serums, and has the function of treating cardiovascular diseases. The composition has definite pharmacodynamic effects, is rigorous in quality control and small in taking dosage and is convenient to take.

The invention provides a simple, convenient and efficient process for synthesizing 6-gingerol, 8-gingerol and 10-gingerol. Deprotonation and straight-chain fatty aldehyde condensation of zingiberone are performed in an inert solvent, so that the crude product of gingerol are obtained. The crude product is subjected to posttreatment at a low temperature and purified through silica gel column chromatography so that 6-gingerol, 8-gingerol or 10-gingerol having the purity exceeding 95% can be obtained. Besides, the yield exceeds 70%.

The invention relates to a preparation method of 6-gingerol. The preparation method comprises the following steps: (1), pretreating: adding an ethanol solution into ginger resin, dissolving, and thenadding water to adjust the volume fraction of ethanol to 50-60% while homogenizing to obtain a ginger resin-ethanol mixed solution; (2), cooling and removing impurities: cooling the ginger resin-ethanol mixed solution in the step (1) till a precipitate is separated out, then raising the temperature to the room temperature, waiting till the precipitate is melted into an oily substance, and then separating to remove the oily substance to obtain an ethanol solution phase; (3), performing liquid-liquid extraction: adjusting the volume fraction of the ethanol in the ethanol solution phase in the step (2) to 70-90%, performing the liquid-liquid extraction by using n-hexane, collecting an ethanol phase, concentrating and removing water to obtain crude 6-gingerol. The content of the 6-gingerol inthe crude 6-gingerol prepared by the preparation method is relatively high, so that obtainment of the high-purity 6-gingerol through purification is facilitated, the yield of the 6-gingerol is increased and the preparation cost is reduced.

The invention discloses a method for extracting and separating 6-gingerol from ginger. The method comprises the following operation steps: solvent extracting, low-pressure silica gel column chromatography separation, high performance liquid chromatography purification and recrystallization. The yield of the 6-gingerol prepared by the method is high; the prepared 6-gingerol is high in biological activity and high in purity, and can be directly used for preparing drugs; the 6-gingerol can be stored in cryoprotectant for a long time; and the biological activity of the 6-gingerol is not reduced.

The invention relates to a quality detection method of a gingerol type extract and soft capsules thereof. The quality detection method specifically comprises trait inspection, identification, content determination and the like, wherein the content determination comprises the determination of total phenols and the determination of 6-gingerol, the determination of the total phenols adopts ultraviolet spectrophotometry, and the determination of the 6-gingerol adopts high performance liquid chromatography. According to the quality detection method disclosed by the invention, by improving the content determination method, the production quality level of an enterprise can be ensured, and the efficacy can be ensured.

The invention discloses an orange peel soup fermented beverage and a preparation method thereof. The preparation method comprises the steps that firstly, fresh and non-corrosive ginger and white granulated sugar are mixed to be uniform, juice is leached out, then the juice is mixed with dried orange peel and water to be uniform, lactobacillus mixed bacteria are added, uniform mixing is conducted,fermentation and filtering are conducted, the mixture is mixed with prebiotics, sterilization and canning are conducted, and the orange peel soup fermented beverage is obtained. According to the method, a mixed probiotic fermented traditional Chinese medicine classical prescription orange peel soup is adopted, compared with the separately fermented ginger and dried orange peel, and preservation ofthe active ingredients of 6-gingerol, nobiletin and hesperidin is better facilitated; for the prepared orange peel soup fermented beverage, not only is the original effect of the orange peel soup retained, but also flavor substances are added; the beverage is mixed with the prebiotics, then the beverage is more suitable for the taste of consumers, and after fermentation is conducted, absorption by the human body is better facilitated.